Yayınlar & Eserler

Yayın Ağı
SCI, SSCI ve AHCI İndekslerine Giren Dergilerde Yayınlanan Makaleler

Revealing third-order interactions through the integration of machine learning and entropy methods in genomic studies

Iyigün C., Aydin Son Y.
BIODATA MINING , cilt.17, sa.1, 2024 (SCI-Expanded) identifier identifier identifier

Multimodal data fusion using sparse canonical correlation analysis and cooperative learning: a COVID-19 cohort study

Aydın Son Y.
npj Digital Medicine , cilt.7, sa.7, ss.1-11, 2024 (SCI-Expanded) identifier identifier identifier

An automated framework for evaluation of deep learning models for splice site predictions

Zabardast A., Tamer E. G., AYDIN SON Y., Yılmaz A.
Scientific Reports , cilt.13, sa.1, 2023 (SCI-Expanded) Creative Commons License identifier identifier identifier

Reflections on Turkish Personal Data Protection Law and Genetic Data in Focus Group Discussions

Özkan Ö., Şahinol M., AYDINOĞLU A. U., AYDIN SON Y.
NanoEthics , cilt.16, sa.3, ss.297-312, 2022 (SCI-Expanded) Creative Commons License identifier identifier

Integrative Predictive Modeling of Metastasis in Melanoma Cancer Based on MicroRNA, mRNA, and DNA Methylation Data

Kutlay A., AYDIN SON Y.
FRONTIERS IN MOLECULAR BIOSCIENCES , cilt.8, 2021 (SCI-Expanded) Sürdürülebilir Kalkınma identifier identifier identifier

Assessing the readiness of Turkish health information systems for integrating genetic/genomic patient data: System architecture and available terminologies, legislative, and protection of personal data

Şık A. S., Aydınoğlu A. U., Aydın Son Y.
HEALTH POLICY , cilt.125, sa.2, ss.203-212, 2021 (SCI-Expanded) identifier identifier identifier

Projecting the course of COVID-19 in Turkey: A probabilistic modeling approach

Acar A. C., Er A. G., Burduroğlu H. C., Sülkü S. N., Aydin Son Y., Akin L., et al.
TURKISH JOURNAL OF MEDICAL SCIENCES , cilt.51, sa.1, ss.16-27, 2021 (SCI-Expanded) Creative Commons License Sürdürülebilir Kalkınma identifier identifier identifier identifier

In vitro effects of boric acid on human liver hepatoma cell line (HepG2) at the half-maximal inhibitory concentration

Tombuloglu A., Copoglu H., AYDIN SON Y., GÜRAY N. T.
Journal of Trace Elements in Medicine and Biology , cilt.62, 2020 (SCI-Expanded) Sürdürülebilir Kalkınma identifier identifier identifier

Evaluation of potential novel variations and their interactions related to bipolar disorders: Analysis of genome-wide association study data

Açikel C., Son Y., Çelik C., Gül H.
Neuropsychiatric Disease and Treatment , cilt.12, ss.2997-3004, 2016 (SCI-Expanded) identifier identifier

Modeling the combined effect of RNA-binding proteins and microRNAs in post-transcriptional regulation

Hafezqorani S., Lafzi A., De Bruin R. G., Van Zonneveld A. J., Van Der Veer E. P., Son Y., et al.
NUCLEIC ACIDS RESEARCH , cilt.44, 2016 (SCI-Expanded) identifier identifier identifier

Reconstruction of the temporal signaling network in Salmonella-infected human cells

Budak G., Ozsoy O. E., Son Y., Can T., Tunçbağ N.
FRONTIERS IN MICROBIOLOGY , cilt.6, 2015 (SCI-Expanded) Sürdürülebilir Kalkınma identifier identifier identifier

Evaluation of Whole Genome Association Study Data in Bipolar Disorders: Potential Novel SNPs and Genes

Cengiz Han A., Aydin Son Y., Çelik C., Recep T.
KLINIK PSIKOFARMAKOLOJI BULTENI-BULLETIN OF CLINICAL PSYCHOPHARMACOLOGY , cilt.25, ss.12-18, 2015 (SCI-Expanded) identifier identifier

Systems-level analysis of genome wide association study results for a pilot juvenile idiopathic arthritis family study

AYDIN SON Y., Batu E. D., Demirkaya E., BİLGİNER Y., KASAPÇOPUR Ö., Unsal E., et al.
TURKISH JOURNAL OF PEDIATRICS , cilt.57, sa.4, ss.324-333, 2015 (SCI-Expanded) identifier identifier

Discovering missing heritability and early risk prediction for type 2 diabetes: a new perspective for genome-wide association study analysis with the Nurses' Health Study and the Health Professionals' Follow-Up Study

Gul H., Aydin Son Y., Acikel C.
TURKISH JOURNAL OF MEDICAL SCIENCES , cilt.44, ss.946-982, 2014 (SCI-Expanded) Sürdürülebilir Kalkınma identifier identifier identifier

Incorporation of personal Single Nucleotide Polymorphism (SNP) data into a national level electronic health record for disease risk assessment, Part 3: An evaluation of SNP Incorporated National Health Information System of Turkey for prostate cancer

Beyan T., AYDIN SON Y.
Journal of Medical Internet Research , cilt.16, sa.8, 2014 (SCI-Expanded) Sürdürülebilir Kalkınma identifier identifier identifier

Incorporation of personal Single Nucleotide Polymorphism (SNP) data into a national level electronic health record for disease risk assessment, part 2: The incorporation of SNP into the national health information system of Turkey

Beyan T., AYDIN SON Y.
Journal of Medical Internet Research , cilt.16, sa.8, 2014 (SCI-Expanded) Sürdürülebilir Kalkınma identifier identifier identifier

A Prostate Cancer Model Build by a Novel SVM-ID3 Hybrid Feature Selection Method Using Both Genotyping and Phenotype Data from dbGaP

Yucebas S. C., Aydin Son Y.
PLOS ONE , cilt.9, 2014 (SCI-Expanded) Creative Commons License Sürdürülebilir Kalkınma identifier identifier identifier

Emerging technologies in health information systems: Genomics driven wellness tracking and management system (GO-WELL)

Beyan T., AYDIN SON Y.
Studies in Computational Intelligence , cilt.546, ss.315-339, 2014 (SCI-Expanded) Sürdürülebilir Kalkınma identifier

Incorporation of personal single nucleotide polymorphism (SNP) data into a national level electronic health record for disease risk assessment, part 1: An overview of requirements

Beyan T., AYDIN SON Y.
Journal of Medical Internet Research , cilt.16, sa.7, 2014 (SCI-Expanded) Sürdürülebilir Kalkınma identifier identifier identifier

Selection of representative SNP sets for genome-wide association studies: a metaheuristic approach

Ustunkar G., Akyüz S., Weber G. W., Friedrich C. M., Aydin Son Y.
OPTIMIZATION LETTERS , cilt.6, ss.1207-1218, 2012 (SCI-Expanded) Sürdürülebilir Kalkınma identifier identifier

The Oak Ridge Polycystic Kidney mouse: Modeling ciliopathies of mice and men

Jonathan M L., Edward J M., Trenton R S., Aydin Son Y., Michael M., Bradley K Y.
DEVELOPMENTAL DYNAMICS , cilt.237, sa.8, ss.1960-1971, 2008 (SCI-Expanded) Creative Commons License Sürdürülebilir Kalkınma identifier identifier identifier

Gli2 and Gli3 localize to cilia and require the intra-flagellar transport protein polaris for processing and function

Haycraft C., Banizs B., Aydin-Son Y., Zhang Q., Michaud E., Yoder B.
PLOS GENETICS , cilt.1, sa.4, ss.480-488, 2005 (SCI-Expanded) identifier identifier identifier

Balanced de novo translocation T(6;7)(p25;q31) and cleft palate as an isolated finding

Balci S., Aypar E., Son Y., Beksac M.
GENETIC COUNSELING , cilt.15, sa.3, ss.317-320, 2004 (SCI-Expanded) identifier identifier identifier

Twenty-nail dystrophy in a mother and her 7-year-old daughter associated with balanced translocation 46, XX, t(6q13;10p13)

Balci S., Kanra G., Aypar E., Son Y.
CLINICAL DYSMORPHOLOGY , cilt.11, sa.3, ss.171-173, 2002 (SCI-Expanded) identifier identifier identifier

A female patient with frontonasal dysplasia sequence and frontonasal encephalocele

Balci S., Mavili M., Son Y., Benli K., Erk Y.
ANNALS OF PLASTIC SURGERY , cilt.43, sa.4, ss.457-459, 1999 (SCI-Expanded) identifier identifier identifier
Diğer Dergilerde Yayınlanan Makaleler

Health-Related Work Loss: Wellness Profiles of Information Technology Employees

Kuru H., Sakmar E., Aydin Son Y., Ince M. L.
Pamukkale Spor Bilimleri Dergisi , cilt.14, sa.3, ss.258-278, 2023 (Scopus) identifier identifier

2012 7th International Symposium on Health Informatics and Bioinformatics, HIBIT 2012: Preface

AYDIN SON Y., CAN T.
2012 7th International Symposium on Health Informatics and Bioinformatics, HIBIT 2012 , 2012 (Scopus) identifier

METU-SNP: an integrated software system for SNP-complex disease association analysis.

Ustünkar G., Aydin Son Y.
Journal of integrative bioinformatics , cilt.8, sa.1, ss.187, 2011 (Scopus) Sürdürülebilir Kalkınma identifier identifier

Ankara Oran Sağlık Ocağı Bölgesine Bağlı İlköğretim Okullarında Çalışan Kadın Öğretmenlerde Osteoporoz Risk Faktörlerinin Boyutunun Saptanması

TEZCAN S., ALTINTAŞ K. H., AYDIN SON Y., ÇIKRIKÇI B. İ., YAVUZ B. B., ERDEM G., et al.
Hacettepe Toplum Hekimliği Bülteni , cilt.20, sa.1, ss.1-5, 1999 (Hakemli Dergi)

Bir Halk Sağlığı Sorunu Osteoporoz

TEZCAN S., ALTINTAŞ K. H., AYDIN SON Y., ÇIKRIKÇI B. İ., YAVUZ B. B., ERDEM G., et al.
Hacettepe Toplum Hekimliği Bülteni , cilt.20, sa.1, ss.5-6, 1999 (Hakemli Dergi)

Ankara Oran sağlık ocağı bölgesine bağlı ilköğretim okullarında çalışan kadın öğretmenlerde osteoporoz risk faktürlerinin boyutunun saptanması

TEZCAN S., ALTINTAŞ K. H., AYDIN SON Y., ÇIKRIKÇI İ., DOĞU B. B., ERDEM G., et al.
Hacettepe Toplum Hekimliği Bülteni , sa.1, ss.1-5, 1999 (Hakemli Dergi)
Hakemli Kongre / Sempozyum Bildiri Kitaplarında Yer Alan Yayınlar

Yeni Medya Odaklı Çalışan Zindeliği Programının Teknokent Çalışanları Üzerine Etkisi

KURU H., SAKMAR BALKAN E., AYDIN SON Y., İNCE M. L.
20th International Sport Sciences Congress, Antalya, Türkiye, 28 Kasım - 01 Aralık 2022

Bioinformatics Education Landscape in Turkey

AYDIN SON Y.
Colloquium on Bioinformatics Learning, Education and Training (CoBLET), İstanbul, Türkiye, 11 - 14 Ekim 2022

Teknokent Çalısanlarının Sağlıklı Yaşam Davranışları ve Demografik Özelliklerinin İş Performansı ile İliskisinin incelenmesi

KURU H., SAKMAR BALKAN E., AYDIN SON Y., İNCE M. L.
19th International Sport Sciences Congress, Türkiye, 11 - 13 Kasım 2021

Identification of genomic biomarkers with machine learning for early and differential diagnosis of late-onset Alzheimer’s disease (LOAD)

Erdoğan O., EŞME M., BALCI C., Rafatov S., CANKURTARAN M., DOĞU B. B., et al.
Alzheimer's & dementia: the journal of the Alzheimer's Association, Türkiye, 16 Eylül 2020

EXPLORING ALTERED REGULATORY TRANSCRIPTION FACTOR-GENE INTERACTIONS INDUCED BY BORIC ACID AT HALF MAXIMAL INHIBITORY CONCENTRATION THROUGH COMBINED USE OF NETWORK MODELING ALGORITHMS

TOMBULOĞLU A., AYDIN SON Y.
12th International Symposium on Health Informatics and Bioinformatics, İzmir, Türkiye, 17 - 19 Ekim 2019

Yüksek Ölçekli Dizileme sonuçlarının Biyoenformatik analizi ve teknik olarak yorumu

AYDIN SON Y.
13. Tıbbi Genetik Kongresi, 7 - 11 Kasım 2018

From NGS to Protein Function: A workflow for evaluation of SNVs based on their impact on the protein function

Yazar Ö. F., Yazar Untekin B., AYDIN SON Y.
11th International Conference on Health Informatics and Bioinformatics, October 2018, Belek, Antalya, Antalya, Türkiye, 26 - 28 Ekim 2018

Türkiye’de Genetik ve Genomik Test Raporlamadaki Güncel Durum

ŞIK A. S., AYDIN SON Y., AYDINOĞLU A. U., SOYSAL E.
STS TURKEY 2018 Toplum için Bilim ve Teknoloji Çalışmaları Konferansı, Ankara, Türkiye, 10 - 11 Eylül 2018

Meme Kanserinde Terapötik Hedef Olarak Kullanılabilecek Özgül Metastaz Baskılayıcı MikroRNA’ların Tespiti

EKENEL E., ERGENE E., AYDIN SON Y.
19. Ulusal, Uluslararası Katılımlı Biyotoknoloji Kongresi, Eskişehir, Türkiye, 1 - 03 Aralık 2017 Sürdürülebilir Kalkınma

A Feature Selection Model for Genome Wide Association Studies of Schizophrenia

DÖM H. A., AYDIN SON Y.
HIBIT 2017, Güzelyurt, Kıbrıs (Kktc), 28 - 30 Haziran 2017

Structural Properties of Methylated Human Promoter Regions in Terms of DNA Helical Rise

YALDIZ B., AYDIN SON Y.
HIBIT 2017, Güzelyurt, Kıbrıs (Kktc), 28 - 30 Haziran 2017

A Data Mining Approach for Directing the Patient to Appropriate Treatment Method in Pain Clinic

MİMAROĞLU ALTINAY B., AYDIN SON Y.
HIBIT 2017, Güzelyurt, Kıbrıs (Kktc), 28 - 30 Haziran 2017

A Conceptual Design for Genetic Information Exchange Coding Standards in Turkey

ŞIK A. S., AYDIN SON Y., SOYSAL E., AYDINOĞLU A. U.
HIBIT 2017, Güzelyurt, Kıbrıs (Kktc), 28 - 30 Haziran 2017

Genome-wide Analysis of Splice Acceptor Site Motifs

BAHÇE KARADUMAN G., AYDIN SON Y.
HIBIT 2017, Güzelyurt, Kıbrıs (Kktc), 28 - 30 Haziran 2017

Changes in gene profile of human hepatocellular carcinoma cell line (HepG2) induced by boric acid at half mazimal inhibitory concentration (IC50).

TOMBULOĞLU A., ÇÖPOĞLU H., GÜRAY N. T., AYDIN SON Y.
HIBIT 2017, Güzelyurt, Kıbrıs (Kktc), 28 - 30 Haziran 2017

Lossless Pruning of AHP SNP Prioritizaton Tree Using Random Forest Variable Importances

YILMAZ A., AYDIN SON Y.
HIBIT 2017, Güzelyurt, Kıbrıs (Kktc), 28 - 30 Haziran 2017 Sürdürülebilir Kalkınma

Participatory Design Meetings: Genetic Information Included Personal Health Record Application

ÖZKAN Ö., AYDIN SON Y., AYDINOĞLU A. U., YALÇIN A., DÖM H. A., YALDIZ B., et al.
HIBIT 2017, Güzelyurt, Kıbrıs (Kktc), 28 - 30 Haziran 2017

Genomic Disease Modelling

AYDIN SON Y.
9th International Symposium on Health Informatics and BioinformaticsHIBIT 2015, Muğla, Türkiye, 16 - 17 Ekim 2015

Gene Regulatory Network Inference based on Temporal Automata Network Model

ÇELEBİ R., KILIÇ H., AYDIN SON Y.
9th International Symposium on Health Informatics and Bioinformatics, Muğla, Türkiye, 16 - 17 Ekim 2015

Reconstruction of the Temporal Signaling Network in Salmonella Infected Human Cells

güngör b., EREN ÖZSOY Ö., AYDIN SON Y., CAN T., nurcan t.
23rd Annual International Conference on Intelligent Systems for Molecular Biology and the 14th European Conference on Computational Biology (ISMBECCB’2015), Dublin, İrlanda, 10 - 14 Temmuz 2015

A Survey to Determine Security and Privacy Measures Needed for Genetic Information Exchange in Personal Health Records

ÖZKAN Ö., ARSEV UMUR A., AYDIN SON Y.
5th International Workshop on Infrastructures on Healthcare, 18 - 19 Haziran 2015

Post transcriptional regulation mediated by the interplay between RNA binding proteins and miRNAs v2

HafezQorani S., Lafzi A., AYDIN SON Y., KAZAN H.
The 7th RECOMB/ISCB Conference on Regulatory and Systems Genomics, with DREAM Challenges, 9 - 14 Kasım 2014

Workflow of Microarray Data Analysis for IdentifyingGenes Related with Hutchinson Gilford Progeria Syndrome

TOMBULOĞLU A., AYDIN SON Y.
3rd International Congress of theMolecular Biology, İzmir, Türkiye, 10 - 12 Eylül 2014

Post transcriptional regulation mediated by the interplay between RNA binding proteins and miRNAs

HafezQorani S., Lafzi A., AYDIN SON Y., KAZAN H.
The 13th European Conference on Computational Biology, 7 - 10 Eylül 2014

Predicting the Disease of Alzheimer With SNP Biomarkers and Clinical Data Using Data Mining Classification Approach: Decision Tree

Erdogan O., AYDIN SON Y.
25th European Medical Informatics Conference (MIE), İstanbul, Türkiye, 31 Ağustos - 03 Eylül 2014, cilt.205, ss.511-515 identifier identifier identifier

A novel SVM-ID3 Hybrid Feature Selection Method to Build a Disease Model for Melanoma using Integrated Genotyping and Phenotype Data from dbGaP

AYDIN SON Y., YÜCEBAŞ S. C.
25th European Medical Informatics Conference (MIE), İstanbul, Türkiye, 31 Ağustos - 03 Eylül 2014, cilt.205, ss.501-505 identifier identifier identifier

Identifying the interactions between RNA binding proteins and miRNAs

Lafzi A., HafezQorani S., AYDIN SON Y., KAZAN H.
25th European Medical Informatics Conference, İstanbul, Türkiye, 31 Ağustos - 03 Eylül 2014

rs10739592 is a New Candidate Loci for Type 2 Diabetes Risk in Men

Gul H., AYDIN SON Y., Acikel C.
25th European Medical Informatics Conference (MIE), İstanbul, Türkiye, 31 Ağustos - 03 Eylül 2014, cilt.205, ss.1268 Sürdürülebilir Kalkınma identifier identifier

Weighting Indirect Relations to Elucidate the Direct Association of SNP-Disease by Use of SPARQL Queries

ÇELEBİ R., GÜMÜŞ Ö., AYDIN SON Y.
6th International Workshop on Semantic Web Applications and Tools for Life Sciences (SWAT4LS 2013), Edinburgh, Saint Helena, 10 Aralık 2013, cilt.1114

Use of open linked data in bioinformatics space: A case study

Çelebi R., GÜMÜŞ Ö., AYDIN SON Y.
2013 8th International Symposium on Health Informatics and Bioinformatics, HIBIT 2013, Ankara, Türkiye, 25 - 27 Eylül 2013 identifier

TCF7L2 gen polimorfizminin diyabetik hastalarda biyoinformatik metotlar ile araştırılması

GÜL H., AÇIKEL C., AYDIN SON Y.
IX. Ulusal Tıp Bilişimi Kongresi, Antalya, Türkiye, 15 Kasım 2012, ss.163-164

GWAS with AHP based SNP prioritization approach to identify SNP biomarkers for Alzheimer's disease

Kadioǧlu O., Üstünkar G., AYDIN SON Y.
2012 7th International Symposium on Health Informatics and Bioinformatics, HIBIT 2012, Cappadocia, Türkiye, 19 - 22 Nisan 2012, ss.7-10 identifier

iSNP: An integrated, automatically updated SNP database

Çarkacioǧlu L., Gedikoǧlu C., AYDIN SON Y.
2012 7th International Symposium on Health Informatics and Bioinformatics, HIBIT 2012, Cappadocia, Türkiye, 19 - 22 Nisan 2012, ss.114-117 identifier

Building Dicer1 regulation network of mouse liver hepatocytes

Ünsal Ş., Beyge M., AYDIN SON Y.
2012 7th International Symposium on Health Informatics and Bioinformatics, HIBIT 2012, Cappadocia, Türkiye, 19 - 22 Nisan 2012, ss.88-94 identifier

M4B: A novel method for designing and ordering of the genetic devices

Hashemikhabir S., Ersoy G., Oguz G., Yaldiz B., Tuncel Y., Budak G., et al.
2012 7th International Symposium on Health Informatics and Bioinformatics, HIBIT 2012, Cappadocia, Türkiye, 19 - 22 Nisan 2012, ss.123-127 identifier

A pilot study for genome wide association study (GWAS) in patients with juvenile idiopathic arthritis (JIA) and their parents

AYDIN SON Y., DEMİRKAYA E., BİLGİNER Y., Açıkel C. H., KASAPÇOPUR Ö., ALİKAŞİFOĞLU M., et al.
18th Pediatric Rheumatology European Society (PReS) Congress, Bruges, Belçika, 14 Eylül 2011

Analysis of SNP-Complex Disease Association by a Novel Feature Selection Method

Ustunkar G., AKYÜZ S., Weber G. -., AYDIN SON Y.
Annual International Conference of the German-Operations-Research-Society (GOR), Neubiberg, Almanya, 1 - 03 Eylül 2010, ss.21-26 identifier
Kitap & Kitap Bölümleri

Genetic and Genomic Testing and Reimbursement: Parameters, Current Practices and Policy Recommendations in Türkiye with Global Perspectives

ŞIK A. S., AYDINOĞLU A. U., AYDIN SON Y.
The Future of Universal Health Insurance, SÜLKÜ SEHER NUR, TOKATLIOĞLU YAĞMUR, Editör, Nova Science Publishers, Inc, New York, ss.169-208, 2024

Dizi Karşılaştırmaları ve Dizi-Temelli Veri Tabanı Aramaları

AYDIN SON Y., TAŞKIN B.
Uygulamalı Biyoenformatik, Münir Tunçer, Hilal Ay, Editör, Palme, ss.35-49, 2019

Emerging Technologies in Health Information Systems: Genomics Driven Wellness Tracking and Management System (GO-WELL)

Beyan T., Aydin Son Y.
Big Data and Internet of Things: A Roadmap for Smart Environments, N. Bessis and C. Dobre, Editör, Springer, London/Berlin , London, ss.315-339, 2014 Creative Commons License

Hastalıkların Genetik Temellerinin Tanımlanması

Aydın Son Y.
Biyologlar için biyoenformatik, Zeki Kaya, Editör, Nobel Yayın Dağıtım, Ankara, ss.3-22, 2013

Designing and Implementing Pharmacogenomics Study

Aydın Son Y., Tüzmen Ş., Hızel C.
Omics for Personalized Medicine , Barh D.,Dhawan D.,Ganguly N., Editör, Springer Nature, New Delhi, ss.97-122, 2013

Analysis of SNP-Complex Disease Association by a Novel Feature Selection Method

ÜSTÜNKAR G., Ozogur-Akyuz S., WEBER G. W., AYDIN SON Y.
Operations Research Proceedings 2010, Bo Hu, Karl Morasch, Stefan Pickl, Markus Siegle, Editör, Springer Science & Business Media, Verlag Berlin Heilderberg, ss.21-26, 2011
Diğer Yayınlar

Security and Privacy Concerns Regarding Genetic Data in Mobile Health Record Systems: An Empirical Study from Turkey

Özkan Ö., Aydin Son Y., Aydinoğlu A. U.
Diğer, ss.1-17, 2019 Sürdürülebilir Kalkınma
Metrikler

Yayın

75

Atıf (WoS)

924

H-İndeks (WoS)

7

Atıf (Scopus)

1011

H-İndeks (Scopus)

10

Atıf (Scholar)

395

H-İndeks (Scholar)

11

Atıf (TrDizin)

5

H-İndeks (TrDizin)

1

Atıf (Diğer Toplam)

8

Proje

11

Tez Danışmanlığı

44

Açık Erişim

26
BM Sürdürülebilir Kalkınma Amaçları