In the life sciences, semantic web can support many aspects of bio- and health informatics, with exciting applications appearing in areas ranging from plant genetics to drug discovery. Using semantic technologies with open linked data, provides two kinds of advantages: ability to search multiple datasets through a single framework and ability to search relationships and paths of relationships that go across different datasets. The Bio2RDF project creates a network of coherently linked data across the biological databases. As part of the Bio2RDF project, an integrated bioinformatics warehouse on the semantic web is built. In this paper, a use case with a query for multiple distant data sources which are semantically available through Bio2RDF is defined. The validation of the results by traditional search techniques and discussion for future directions is presented. © 2013 IEEE.