Building Dicer1 regulation network of mouse liver hepatocytes


Ünsal Ş., Beyge M., AYDIN SON Y.

2012 7th International Symposium on Health Informatics and Bioinformatics, HIBIT 2012, Cappadocia, Turkey, 19 - 22 April 2012, pp.88-94 identifier

  • Publication Type: Conference Paper / Full Text
  • Volume:
  • Doi Number: 10.1109/hibit.2012.6209048
  • City: Cappadocia
  • Country: Turkey
  • Page Numbers: pp.88-94

Abstract

RNA induced gene silencing complex (RISC) has a role in many cellular processes which includes regulation of gene expression, immune response, cell differentiation and embryonic development. Dicer protein is a key regulator of these processes. Dicer1 specifically has central role in maturation of RISC substrate RNA and RISC assembly in mouse. Here the results of a microarray study that investigates the molecular level changes in dicer1 knockout mouse liver hepatocytes is re-analysed and the differentially regulated genes are hierarchically clustered based on molecular function and co-expression to construct the suggested regulation network of Dicer1 in mouse hepatocytes. © 2012 IEEE.