Biography
Dr. Altuğ Özçelikkale holds a B.S (2008) and an M.S (2010) degree in Mechanical Engineering from Middle East Technical University and a Ph.D. (2015) degree from Purdue University. He pursued his Ph.D. studies at Biotransport Phenomena Laboratory in the School of Mechanical Engineering. Before he joined METU, he was a Postdoctoral Research Associate in the Department of Physics and Institute for Physical Science and Technology at the University of Maryland College Park. He was also a Visiting Scholar at Johns Hopkins University.
Education Information
2010 - 2015
2010 - 2015Doctorate
Purdue University, United States Of America
2008 - 2010
2008 - 2010Postgraduate
Middle East Technical University, Turkey
2004 - 2008
2004 - 2008Undergraduate
Middle East Technical University, Faculty of Engineering, Turkey
Dissertations
2015
2015Doctorate
Freezing-Induced Deformation of Biomaterials in Cryomedicine
Purdue University, Faculty of Engineering, School of Mechanical Engineering
2010
2010Postgraduate
Development of an incompressible, laminar flow solver based on least squares spectral element method with P-type adaptive refinement capabilities
Middle East Technical University
Foreign Languages
C2 Mastery
C2 MasteryEnglish
Research Areas
Bioengineering and MEMS
Bioinstrumentation and Microelectromechanical Systems (MEMS)
Biomedical Image Processing
Biomechanics
Artificial Organs and Biomaterials
Non-traditional manufacturing methods
Biomechanics
Heat and Mass Transfer
Academic Titles / Tasks
2021 - Continues
2021 - ContinuesAssistant Professor
Middle East Technical University, Graduate School of Natural and Applied Sciences, Biomedical Engineering
2020 - Continues
2020 - ContinuesAssistant Professor
Middle East Technical University, Faculty of Engineering, Department of Mechanical Engineering
2017 - 2019
2017 - 2019Researcher
University of Maryland, College Park, Institute for Physical Science and Technology, Department of Physics
2016 - 2017
2016 - 2017Researcher
Johns Hopkins University, School of Engineering, Department of Mechanical Engineering
2015 - 2016
2015 - 2016Researcher
Purdue University, College of Engineering, School of Mechanical Engineering
2010 - 2015
2010 - 2015Research Assistant
Purdue University, College of Engineering, School of Mechanical Engineering
Managerial Experience
2022 - Continues
2022 - ContinuesPublicity and Communication Committee Member
Middle East Technical University, Faculty of Engineering, Department of Mechanical Engineering
2022 - Continues
2022 - ContinuesBiomechanics Track Representative
Middle East Technical University, Graduate School of Natural and Applied Sciences, Biomedical Engineering
2020 - Continues
2020 - ContinuesÜZEM Advisory Board Member
Middle East Technical University, Faculty of Engineering, Department of Mechanical Engineering
2020 - Continues
2020 - ContinuesDistance Education Coordinator
Middle East Technical University, Faculty of Engineering, Department of Mechanical Engineering
Published journal articles indexed by SCI, SSCI, and AHCI
2024
2024Exploiting Matrix Stiffness to Overcome Drug Resistance
Aydin H. B., ÖZÇELİKKALE A., ACAR A.
ACS BIOMATERIALS SCIENCE & ENGINEERING
, vol.10, no.8, pp.4682-4700, 2024 (SCI-Expanded)
2023
2023Predictive Design and Analysis of Drug Transport by MultiScale Computational Models Under Uncertainty
AKALIN A. A., DEDEKARGINOĞLU B., Choi S. R., Han B., ÖZÇELİKKALE A.
Pharmaceutical Research
, vol.40, no.2, pp.501-523, 2023 (SCI-Expanded)
2022
2022Migration and 3D Traction Force Measurements inside Compliant Microchannels
Afthinos A., Bera K., Chen J., Ozcelikkale A., Amitrano A., Choudhury M. I., et al.
NANO LETTERS
, vol.22, no.18, pp.7318-7327, 2022 (SCI-Expanded)
2022
2022Cytotoxic T Lymphocyte Activation Signals Modulate Cytoskeletal Dynamics and Mechanical Force Generation
Pathni A., Ozcelikkale A., Rey-Suarez I., Li L., Davis S., Rogers N., et al.
FRONTIERS IN IMMUNOLOGY
, vol.13, 2022 (SCI-Expanded)
2020
2020An engineered pancreatic cancer model with intra-tumoral heterogeneity of driver mutations
Moon H., Ozcelikkale A., Yang Y., Elzey B. D., Konieczny S. F., Han B.
LAB ON A CHIP
, vol.20, no.20, pp.3720-3732, 2020 (SCI-Expanded)
2017
2017Differential response to doxorubicin in breast cancer subtypes simulated by a microfluidic tumor model
Ozcelikkale A., Shin K., Noe-Kim V., Elzey B. D., Dong Z., Zhang J., et al.
JOURNAL OF CONTROLLED RELEASE
, vol.266, pp.129-139, 2017 (SCI-Expanded)
2017
2017Effects of dynamic matrix remodelling on en masse migration of fibroblasts on collagen matrices
Ozcelikkale A., Dutton J. C., Grinnell F., Han B.
JOURNAL OF THE ROYAL SOCIETY INTERFACE
, vol.14, no.135, 2017 (SCI-Expanded)
2017
2017Enzyme-Induced Matrix Softening Regulates Hepatocarcinoma Cancer Cell Phenotypes
Liang Y., Clay N. E., Sullivan K. M., Leong J., Ozcelikkale A., Rich M. H., et al.
MACROMOLECULAR BIOSCIENCE
, vol.17, no.9, 2017 (SCI-Expanded)
2017
2017In vitro microfluidic models of tumor microenvironment to screen transport of drugs and nanoparticles
Ozcelikkale A., Moon H., Linnes M., Han B.
WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY
, vol.9, no.5, 2017 (SCI-Expanded)
2017
2017Subcellular domain-dependent molecular hierarchy of SFK and FAK in mechanotransduction and cytokine signaling
Wan Q., ThucNhi TruongVo T. T., Steele H. E., Ozcelikkale A., Han B., Wang Y., et al.
SCIENTIFIC REPORTS
, vol.7, 2017 (SCI-Expanded)
2016
2016Modulation of Matrix Softness and Interstitial Flow for 3D Cell Culture Using a Cell-Microenvironment-on-a-Chip System
Clay N. E., Shin K., Ozcelikkale A., Lee M. K., Rich M. H., Kim D. H., et al.
ACS BIOMATERIALS SCIENCE & ENGINEERING
, vol.2, no.11, pp.1968-1975, 2016 (SCI-Expanded)
2016
2016Role of intracellular poroelasticity on freezing-induced deformation of cells in engineered tissues
Ghosh S., Ozcelikkale A., Dutton J. C., Han B.
JOURNAL OF THE ROYAL SOCIETY INTERFACE
, vol.13, no.123, 2016 (SCI-Expanded)
2016
2016DNA Walker-Regulated Cancer Cell Growth Inhibition
Li F., Cha T., Pan J., Ozcelikkale A., Han B., Choi J. H.
CHEMBIOCHEM
, vol.17, no.12, pp.1138-1141, 2016 (SCI-Expanded)
2016
2016Thermal Destabilization of Collagen Matrix Hierarchical Structure by Freeze/Thaw
Ozcelikkale A., Han B.
PLOS ONE
, vol.11, no.1, 2016 (SCI-Expanded)
2014
2014Simulation of complex transport of nanoparticles around a tumor using tumor-microenvironment-on-chip
Kwak B., Ozcelikkale A., Shin C. S., Park K., Han B.
JOURNAL OF CONTROLLED RELEASE
, vol.194, pp.157-167, 2014 (SCI-Expanded)
2013
2013Role of Cells in Freezing-Induced Cell-Fluid-Matrix Interactions Within Engineered Tissues
Seawright A., Ozcelikkale A., Dutton C., Han B.
JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME
, vol.135, no.9, 2013 (SCI-Expanded)
2013
2013Multifaceted Transport Characteristics of Nanomedicine: Needs for Characterization in Dynamic Environment
Ozcelikkale A., Ghosh S., Han B.
MOLECULAR PHARMACEUTICS
, vol.10, no.6, pp.2111-2126, 2013 (SCI-Expanded)
2012
2012Least-squares spectral element solution of incompressible Navier-Stokes equations with adaptive refinement
Ozcelikkale A., SERT C.
JOURNAL OF COMPUTATIONAL PHYSICS
, vol.231, no.9, pp.3755-3769, 2012 (SCI-Expanded)
Articles Published in Other Journals
2024
2024Tumor-Microenvironment-on-Chip Platform for Assessing Drug Response in 3D Dynamic Culture
Aydin H. B., Moon H., Han B., ÖZÇELİKKALE A., ACAR A.
Methods in molecular biology (Clifton, N.J.)
, vol.2764, pp.265-278, 2024 (Scopus)
Refereed Congress / Symposium Publications in Proceedings
2022
2022Modeling and Characterization of Nanomedicine Transport within Tumor Microenvironment across Scales
Akalin A. A., Özçelikkale A.
16th Nanoscience and Nanotechnology Conference, Ankara, Turkey, 5 - 08 September 2022, pp.338
2021
2021Rapid Low-Cost Prototyping of Organ-on-Chip Platforms by 3D-Printed Microfluidics
Dedekargınoğlu B., Akalın A. A., Özçelikkale A.
3rd Annual European Organ-on-Chip Society Meeting, Uppsala, Sweden, 01 July 2021
2018
2018Regulation of Cytoskeletal Dynamics during T Cell Activation by Substrate Stiffness
Özçelikkale A., Upadhyaya A.
American Physical Society March Meeting, California, United States Of America, 07 March 2018, pp.1
2012
2012NANOSCALE FLUID-STRUCTURE INTERACTIONS IN CYTOPLASM DURING FREEZING
Ozcelikkale A., Han B.
ASME International Mechanical Engineering Congress and Exposition, Texas, United States Of America, 9 - 15 November 2012, pp.711-716
2013
2013EFFECTS OF FREEZING ON COLLAGEN NANOSCALE STRUCTURE IN ENGINEERED TISSUES
Ozcelikkale A., Li Y., Xu X., Han B.
2nd ASME Global Congress on NanoEngineering for Medicine and Biology, Massachusetts, United States Of America, 4 - 06 February 2013, pp.29-30
2012
2012FUNCTIONAL IMAGING OF MATRIX STRUCTURE OF CRYOPRESERVED ENGINEERED TISSUES USING BACK-DIRECTIONAL GATED MESOSCOPIC IMAGING
Kim Y. L., Xu Z., Ozcelikkale A., Han B.
ASME Summer Bioengineering Conference (SBC), Fajardo, Puerto Rico, 20 - 23 June 2012, pp.259-260
2012
2012ROLE OF CELLS IN FREEZING-INDUCED CELL-FLUID MATRIX INTERACTIONS WITHIN ENGINEERED TISSUES
Seawright A., Ozcelikkale A., Dutton J. C., Han B.
ASME Summer Bioengineering Conference (SBC), Fajardo, Puerto Rico, 20 - 23 June 2012, pp.409-410
2010
2010h- and p-Adaptive Incompressible Flow Solutions on Cartesian Grids Using Least Squares Spectral Element Method
Özçelikkale A., Sert C.
5th European Conf. on CFD (ECCOMAS CFD), Lisbon, Portugal, 14 - 17 June 2010, pp.1-16
Scholarships
2020 - Continues
2020 - Continues2232 International Fellowship for Outstanding Researchers
TUBITAK
2010 - 2011
2010 - 2011Ross Graduate Fellowship
University
2008 - 2010
2008 - 2010