Metrics
Publication
36
Open Access
3
UN Sustainable Development Goals
Biography
Dr. Altuğ Özçelikkale holds a B.S (2008) and an M.S (2010) degree in Mechanical Engineering from Middle East Technical University and a Ph.D. (2015) degree from Purdue University. He pursued his Ph.D. studies at Biotransport Phenomena Laboratory in the School of Mechanical Engineering. Before he joined METU, he was a Postdoctoral Research Associate in the Department of Physics and Institute for Physical Science and Technology at the University of Maryland College Park. He was also a Visiting Scholar at Johns Hopkins University.
Education
2010 - 2015
2010 - 2015Doctorate
Purdue University, United States Of America
2008 - 2010
2008 - 2010Postgraduate
Middle East Technical University, Turkey
2004 - 2008
2004 - 2008Undergraduate
Middle East Technical University, Faculty of Engineering, Turkey
Dissertations
2015
2015Doctorate
Freezing-Induced Deformation of Biomaterials in Cryomedicine
Purdue University, Faculty of Engineering, School of Mechanical Engineering
2010
2010Postgraduate
Development of an incompressible, laminar flow solver based on least squares spectral element method with P-type adaptive refinement capabilities
Middle East Technical University
Foreign Languages
C2 Mastery
C2 MasteryEnglish
Research Areas
Bioengineering and MEMS
Bioinstrumentation and Microelectromechanical Systems (MEMS)
Biomedical Image Processing
Biomechanics
Artificial Organs and Biomaterials
Non-traditional manufacturing methods
Biomechanics
Heat and Mass Transfer
Research Areas Based on Academic Activities
Avesis Research Areas
WoS Research Areas
Scopus Research Areas
Academic Positions
2021 - Continues
2021 - ContinuesAssistant Professor
Middle East Technical University, Graduate School of Natural and Applied Sciences, Biomedical Engineering
2020 - Continues
2020 - ContinuesAssistant Professor
Middle East Technical University, Faculty of Engineering, Department of Mechanical Engineering
2017 - 2019
2017 - 2019Researcher
University of Maryland, College Park, Institute for Physical Science and Technology, Department of Physics
2016 - 2017
2016 - 2017Researcher
Johns Hopkins University, School of Engineering, Department of Mechanical Engineering
2015 - 2016
2015 - 2016Researcher
Purdue University, College of Engineering, School of Mechanical Engineering
2010 - 2015
2010 - 2015Research Assistant
Purdue University, College of Engineering, School of Mechanical Engineering
Managerial Experience
2024 - Continues
2024 - ContinuesLaboratory Committee Coordinator
Middle East Technical University, Faculty Of Engineering, Department Of Mechanical Engineering
2023 - Continues
2023 - ContinuesQuality Coordinator
Middle East Technical University, Faculty Of Engineering, Department Of Mechanical Engineering
2022 - Continues
2022 - ContinuesPublicity and Communication Committee Member
Middle East Technical University, Faculty of Engineering, Department of Mechanical Engineering
2022 - Continues
2022 - ContinuesBiomechanics Track Representative
Middle East Technical University, Graduate School of Natural and Applied Sciences, Biomedical Engineering
2020 - Continues
2020 - ContinuesÜZEM Advisory Board Member
Middle East Technical University, Faculty of Engineering, Department of Mechanical Engineering
2020 - Continues
2020 - ContinuesDistance Education Coordinator
Middle East Technical University, Faculty of Engineering, Department of Mechanical Engineering
Supervised Theses
2024
2024Postgraduate
INVESTIGATION OF MIGRATION OF BREAST CANCER CELLS IN RELATION TO FIBROBLASTS ON A MICROFLUIDIC SYSTEM
Acar A., Özçelikkale A. (Co-Advisor)
C.ILDIZ(Student)
2023
2023Postgraduate
Modeling and characterization of fluid, macromolecule, and nanoparticle transport in fibrous collagen hydrogels
Özçelikkale A. (Advisor)
A.AYKUT(Student)
2023
2023Postgraduate
Rapid prototyping of microfluidic tissue culture systems via mask based photo polymerization
Özçelikkale A. (Advisor)
B.DEDEKARGINOĞLU(Student)
2023
2023Postgraduate
Development of a micro-well-based microfluidic 3D cell culture for cytotoxicity assays
Özçelikkale A. (Co-Advisor), Yıldırım E.
S.FARAHANI(Student)
Articles
All (20)
SCI-E, SSCI, AHCI (18)
SCI-E, SSCI, AHCI, ESCI (18)
Scopus (20)
2024
20241. Exploiting Matrix Stiffness to Overcome Drug Resistance
Aydin H. B., ÖZÇELİKKALE A., ACAR A.
ACS BIOMATERIALS SCIENCE & ENGINEERING
, vol.10, no.8, pp.4682-4700, 2024 (SCI-Expanded, Scopus)
2024
20242. Tumor-Microenvironment-on-Chip Platform for Assessing Drug Response in 3D Dynamic Culture
Aydin H. B., Moon H., Han B., ÖZÇELİKKALE A., ACAR A.
Methods in molecular biology (Clifton, N.J.)
, vol.2764, pp.265-278, 2024 (Scopus)
2023
20233. Predictive Design and Analysis of Drug Transport by MultiScale Computational Models Under Uncertainty
AKALIN A. A., DEDEKARGINOĞLU B., Choi S. R., Han B., ÖZÇELİKKALE A.
Pharmaceutical Research
, vol.40, no.2, pp.501-523, 2023 (SCI-Expanded, Scopus)
2022
20224. Migration and 3D Traction Force Measurements inside Compliant Microchannels
Afthinos A., Bera K., Chen J., Ozcelikkale A., Amitrano A., Choudhury M. I., et al.
NANO LETTERS
, vol.22, no.18, pp.7318-7327, 2022 (SCI-Expanded, Scopus)
2022
20225. Cytotoxic T Lymphocyte Activation Signals Modulate Cytoskeletal Dynamics and Mechanical Force Generation
Pathni A., Ozcelikkale A., Rey-Suarez I., Li L., Davis S., Rogers N., et al.
FRONTIERS IN IMMUNOLOGY
, vol.13, 2022 (SCI-Expanded, Scopus)
2020
20206. An engineered pancreatic cancer model with intra-tumoral heterogeneity of driver mutations
Moon H., Ozcelikkale A., Yang Y., Elzey B. D., Konieczny S. F., Han B.
LAB ON A CHIP
, vol.20, no.20, pp.3720-3732, 2020 (SCI-Expanded, Scopus)
2017
20177. Differential response to doxorubicin in breast cancer subtypes simulated by a microfluidic tumor model
Ozcelikkale A., Shin K., Noe-Kim V., Elzey B. D., Dong Z., Zhang J., et al.
JOURNAL OF CONTROLLED RELEASE
, vol.266, pp.129-139, 2017 (SCI-Expanded, Scopus)
2017
20178. Effects of dynamic matrix remodelling on en masse migration of fibroblasts on collagen matrices
Ozcelikkale A., Dutton J. C., Grinnell F., Han B.
JOURNAL OF THE ROYAL SOCIETY INTERFACE
, vol.14, no.135, 2017 (SCI-Expanded, Scopus)
2017
20179. In vitro microfluidic models of tumor microenvironment to screen transport of drugs and nanoparticles
Ozcelikkale A., Moon H., Linnes M., Han B.
WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY
, vol.9, no.5, 2017 (SCI-Expanded, Scopus)
2017
201710. Enzyme-Induced Matrix Softening Regulates Hepatocarcinoma Cancer Cell Phenotypes
Liang Y., Clay N. E., Sullivan K. M., Leong J., Ozcelikkale A., Rich M. H., et al.
MACROMOLECULAR BIOSCIENCE
, vol.17, no.9, 2017 (SCI-Expanded, Scopus)
2017
201711. Subcellular domain-dependent molecular hierarchy of SFK and FAK in mechanotransduction and cytokine signaling
Wan Q., ThucNhi TruongVo T. T., Steele H. E., Ozcelikkale A., Han B., Wang Y., et al.
SCIENTIFIC REPORTS
, vol.7, 2017 (SCI-Expanded, Scopus)
2016
201612. Modulation of Matrix Softness and Interstitial Flow for 3D Cell Culture Using a Cell-Microenvironment-on-a-Chip System
Clay N. E., Shin K., Ozcelikkale A., Lee M. K., Rich M. H., Kim D. H., et al.
ACS BIOMATERIALS SCIENCE & ENGINEERING
, vol.2, no.11, pp.1968-1975, 2016 (SCI-Expanded, Scopus)
2016
201613. Role of intracellular poroelasticity on freezing-induced deformation of cells in engineered tissues
Ghosh S., Ozcelikkale A., Dutton J. C., Han B.
JOURNAL OF THE ROYAL SOCIETY INTERFACE
, vol.13, no.123, 2016 (SCI-Expanded, Scopus)
2016
201614. DNA Walker-Regulated Cancer Cell Growth Inhibition
Li F., Cha T., Pan J., Ozcelikkale A., Han B., Choi J. H.
CHEMBIOCHEM
, vol.17, no.12, pp.1138-1141, 2016 (SCI-Expanded, Scopus)
2016
201615. Thermal Destabilization of Collagen Matrix Hierarchical Structure by Freeze/Thaw
Ozcelikkale A., Han B.
PLOS ONE
, vol.11, no.1, 2016 (SCI-Expanded, Scopus)
2014
201416. Simulation of complex transport of nanoparticles around a tumor using tumor-microenvironment-on-chip
Kwak B., Ozcelikkale A., Shin C. S., Park K., Han B.
JOURNAL OF CONTROLLED RELEASE
, vol.194, pp.157-167, 2014 (SCI-Expanded, Scopus)
2013
201317. Role of Cells in Freezing-Induced Cell-Fluid-Matrix Interactions Within Engineered Tissues
Seawright A., Ozcelikkale A., Dutton C., Han B.
JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME
, vol.135, no.9, 2013 (SCI-Expanded, Scopus)
2013
201318. Multifaceted Transport Characteristics of Nanomedicine: Needs for Characterization in Dynamic Environment
Ozcelikkale A., Ghosh S., Han B.
MOLECULAR PHARMACEUTICS
, vol.10, no.6, pp.2111-2126, 2013 (SCI-Expanded, Scopus)
2013
201319. Spatiotemporal characterization of extracellular matrix microstructures in engineered tissue: A whole-field spectroscopic imaging approach
Xu Z., ÖZÇELİKKALE A., Kim Y. L., Han B.
Journal of Nanotechnology in Engineering and Medicine
, vol.4, no.1, 2013 (Scopus)
2012
201220. Least-squares spectral element solution of incompressible Navier-Stokes equations with adaptive refinement
Ozcelikkale A., SERT C.
JOURNAL OF COMPUTATIONAL PHYSICS
, vol.231, no.9, pp.3755-3769, 2012 (SCI-Expanded, Scopus)
Papers Presented at Peer-Reviewed Scientific Conferences
2024
20241. Prototyping of a Microfluidic Mechanochemical Gradient Chip by 3D Printed Molding for In Vitro Drug Testing
Fathi M., Mehrasa A., Özçelikkale A.
SB3C2024 Summer Biomechanics, Bioengineering and Biotransport Conference, Wisconsin, United States Of America, 10 - 14 June 2024, pp.806-807, (Summary Text)
2023
20232. Parametric design and manufacturing of mammary carcinoma chip by stereolithography for simulating drug transport around the tumor
Fathi M., Dedekargınoğlu B., Akalın A. A., Özçelikkale A.
The 2nd Microphysiological Systems World Summit, Berlin, Germany, 26 - 30 June 2023, vol.11, no.1, pp.235-236, (Summary Text)
2023
20233. Rapid prototyping of microfluidic co-culture platform based on a 3D printing workflow for systematic investigation of tumor stromal interactions
Dedekargınoğlu B., Ildız C., Acar A., Özçelikkale A.
The 2nd Microphysiological Systems World Summit, Berlin, Germany, 26 - 30 June 2023, vol.11, no.1, pp.200, (Summary Text)
2023
20234. Capillary pressure barriers for spatial confinement in organ-on-a-chip devices
Açıkgöz B. C., Dirmencioğlu U., Farahani S., Özçelikkale A., Yildirim E.
5th NOVEL FLUIDIC TECHNOLOGIES WORKSHOP WITH AN EMPHASIS ON TISSUE ENGINEERING, İzmir, Turkey, 4 - 05 May 2023, pp.29-31, (Summary Text)
2022
20225. Modeling and Characterization of Nanomedicine Transport within Tumor Microenvironment across Scales
Akalin A. A., Özçelikkale A.
16th Nanoscience and Nanotechnology Conference, Ankara, Turkey, 5 - 08 September 2022, pp.338, (Summary Text)
2021
20216. Rapid Low-Cost Prototyping of Organ-on-Chip Platforms by 3D-Printed Microfluidics
Dedekargınoğlu B., Akalın A. A., Özçelikkale A.
3rd Annual European Organ-on-Chip Society Meeting, Uppsala, Sweden, 01 July 2021, (Summary Text)
2018
20187. Regulation of Cytoskeletal Dynamics during T Cell Activation by Substrate Stiffness
Özçelikkale A., Upadhyaya A.
American Physical Society March Meeting, California, United States Of America, 07 March 2018, pp.1, (Summary Text)
2012
20128. NANOSCALE FLUID-STRUCTURE INTERACTIONS IN CYTOPLASM DURING FREEZING
Ozcelikkale A., Han B.
ASME International Mechanical Engineering Congress and Exposition, Texas, United States Of America, 9 - 15 November 2012, pp.711-716, (Full Text)
2013
20139. EFFECTS OF FREEZING ON COLLAGEN NANOSCALE STRUCTURE IN ENGINEERED TISSUES
Ozcelikkale A., Li Y., Xu X., Han B.
2nd ASME Global Congress on NanoEngineering for Medicine and Biology, Massachusetts, United States Of America, 4 - 06 February 2013, pp.29-30, (Full Text)
2012
201210. FUNCTIONAL IMAGING OF MATRIX STRUCTURE OF CRYOPRESERVED ENGINEERED TISSUES USING BACK-DIRECTIONAL GATED MESOSCOPIC IMAGING
Kim Y. L., Xu Z., Ozcelikkale A., Han B.
ASME Summer Bioengineering Conference (SBC), Fajardo, Puerto Rico, 20 - 23 June 2012, pp.259-260, (Full Text)
2012
201211. ROLE OF CELLS IN FREEZING-INDUCED CELL-FLUID MATRIX INTERACTIONS WITHIN ENGINEERED TISSUES
Seawright A., Ozcelikkale A., Dutton J. C., Han B.
ASME Summer Bioengineering Conference (SBC), Fajardo, Puerto Rico, 20 - 23 June 2012, pp.409-410, (Full Text)
2010
201012. h- and p-Adaptive Incompressible Flow Solutions on Cartesian Grids Using Least Squares Spectral Element Method
Özçelikkale A., Sert C.
5th European Conf. on CFD (ECCOMAS CFD), Lisbon, Portugal, 14 - 17 June 2010, pp.1-16, (Full Text)
Funded Projects
2025 - 2028
2025 - 2028Multimodal Mekanik Uyarım Sırasında Hücresel Kuvvet Ölçümü Için Modüler In Vitro Çoklu Hücre Kültürü Gelistirilmesi
TUBITAK Project , 1001 - Program for Supporting Scientific and Technological Research Projects
Özçelikkale A. (Executive), Acar A.
2023 - 2025
2023 - 2025Mikroakışkan Sistemlerin Biyomedikal Uygulamaları İçin Düşük Maliyetli Stereolitografi Mikro İmalat Yaklaşımları
Project Supported by Higher Education Institutions , BAP Other
ÖZÇELİKKALE A. (Executive)
2023 - 2024
2023 - 2024Stres Granül Bozulumunun Zaman Aşamalı Mikroskoskop ile Takibi
Project Supported by Higher Education Institutions , BAP Research Project
MUYAN M. (Executive), ÖZÇELİKKALE A., TURAN G.
2020 - 2023
2020 - 2023
Artificial Tissue Environments with Microfluidics for Next Generation Predictive Disease Models
TUBITAK Project , 2232 - Dormitory Research Scholarship Program
(Project Abstract)
ÖZÇELİKKALE A. (Executive)
Scientific Project Refereeing
August 2023
August 2023Research Project of the Presidency of Turkey Health Institutes (TÜSEB)
Middle East Technical University, Turkey
June 2023
June 2023Project Supported by Higher Education Institutions
BAP Research Project, Middle East Technical University, Turkey
Invited Talks
September 2024
September 2024How to Stop Worrying and Love the Microscope: An Introduction to Microscopy Imaging Techniques and Analysis
Workshop
ODTÜ MEMS Merkezi-Turkey
November 2022
November 2022Next-Generation Engineered Models of Physiological Tissue Microenvironment in Health and Disease
Seminar
Sabancı Üniversitesi-Turkey
April 2022
April 2022Next Generation Engineered Models of Physiological Tissue Microenvironment in Health and Disease
Seminar
Orta Doğu Teknik Üniversitesi-Turkey
Scholarships
2020 - 2023
2020 - 20232232 International Fellowship for Outstanding Researchers
TUBITAK
2010 - 2011
2010 - 2011Ross Graduate Fellowship
University
2008 - 2010
2008 - 2010