DNA Walker-Regulated Cancer Cell Growth Inhibition

Li F., Cha T., Pan J., Ozcelikkale A. , Han B., Choi J. H.

CHEMBIOCHEM, cilt.17, sa.12, ss.1138-1141, 2016 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 17 Konu: 12
  • Basım Tarihi: 2016
  • Doi Numarası: 10.1002/cbic.201600052
  • Dergi Adı: CHEMBIOCHEM
  • Sayfa Sayıları: ss.1138-1141

Özet

We demonstrate a DNAzyme-based walker system as a controlled oligonucleotide drug AS1411 release platform for breast cancer treatment. In this system, AS1411 strands are released from fuel strands as a walker moves along its carbon nanotube track. The release rate and amount of anticancer oligonucleotides are controlled by the walker operation. With a walker system embedded within the collagen extracellular matrix, we show that this drug release system can be used for in situ cancer cell growth inhibition.