Exploiting Matrix Stiffness to Overcome Drug Resistance


Aydin H. B., ÖZÇELİKKALE A., ACAR A.

ACS BIOMATERIALS SCIENCE & ENGINEERING, cilt.10, sa.8, ss.4682-4700, 2024 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 10 Sayı: 8
  • Basım Tarihi: 2024
  • Doi Numarası: 10.1021/acsbiomaterials.4c00445
  • Dergi Adı: ACS BIOMATERIALS SCIENCE & ENGINEERING
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, Chemical Abstracts Core, Compendex, EMBASE, MEDLINE
  • Sayfa Sayıları: ss.4682-4700
  • Anahtar Kelimeler: cancer drug resistance, extracellular matrix, matrix biology, matrix stiffness, tumor microenvironment
  • Orta Doğu Teknik Üniversitesi Adresli: Evet

Özet

Drug resistance is arguably one of the biggest challenges facing cancer research today. Understanding the underlying mechanisms of drug resistance in tumor progression and metastasis are essential in developing better treatment modalities. Given the matrix stiffness affecting the mechanotransduction capabilities of cancer cells, characterization of the related signal transduction pathways can provide a better understanding for developing novel therapeutic strategies. In this review, we aimed to summarize the recent advancements in tumor matrix biology in parallel to therapeutic approaches targeting matrix stiffness and its consequences in cellular processes in tumor progression and metastasis. The cellular processes governed by signal transduction pathways and their aberrant activation may result in activating the epithelial-to-mesenchymal transition, cancer stemness, and autophagy, which can be attributed to drug resistance. Developing therapeutic strategies to target these cellular processes in cancer biology will offer novel therapeutic approaches to tailor better personalized treatment modalities for clinical studies.