Metrikler
Yayın
37
Açık Erişim
9
BM Sürdürülebilir Kalkınma Amaçları
Biyografi
During my undergraduate studies, I visited Prof Robert A. Weinberg’s Laboratory at Massachusetts Institute of Technology, Cambridge, MA, US. as a summer student. After receiving my BSc degree, I won a competitive Cancer Research UK scholarship to enrol in a Ph.D. program at Cancer Research UK Manchester Institute, Manchester, UK, between 2008 and 2012. During my Ph.D., I focused on the evolution of cancer-associated fibroblasts in breast cancer mediated by crosstalk of signaling pathways namely Notch, TGFb, and SDF1. Following my Ph.D., I did a postdoc at the Faculty of Biology, Medicine, and Health, University of Manchester (UoM) for 3 years. My research there focused on the crosstalk of Wnt and Notch signaling and how they regulate each other. Next, I moved to the Institute of Cancer Research in London for the next 4 years where I switched my focus to cancer evolution and genomics to understand the underlying mechanisms of treatment resistance by designing experimental model systems consisting of large Hyperflasks, single-cell barcoding, and patient-derived organoids.
At the beginning of 2020, I moved to Turkey to start my own research group in Ankara’s Middle East Technical University (METU) as part of an International Fellowship for Outstanding Researchers Program administrated by TUBITAK. In addition to my academic journey, I am the founder and CEO of a start-up called HistoCan at METU Teknopark since 2021.
Eğitim Bilgileri
2008 - 2012
2008 - 2012Bütünleşik Doktora
The University of Manchester, Faculty of Medicine, Cancer Sciences, Birleşik Krallık
2002 - 2007
2002 - 2007Lisans
Orta Doğu Teknik Üniversitesi, Fen Edebiyat Fakültesi, Biyolojik Bilimler Bölümü, Türkiye
Araştırma Alanları
Tıp
Temel Eczacılık Bilimleri
Meslek Bilimleri
Eczacılık Teknolojisi
Biyoenformatik
Biyoenstrümantasyon ve MEMS
Biyomedikal Görüntü İşleme
Biyomedikal Görüntü İşleme
Klinik Mühendisliği
Teletıp
Teletıp
Biyofizik
Biyokimya
Biyoinformatik
Biyolojik Modelleme
Biyolojik Veritabanları
Genetik Bozuklukların Moleküler Biyolojisi
Genetik Mühendisliği
Genomiks
Hayvan Moleküler Genetiği
Kanser Moleküler Biyolojisi
Mikrobiyal Genetik
Evrim
Bilgisayar Bilimleri
Oyun Kuramı
Sağlık Bilimleri
Temel Bilimler
Akademik Ünvanlar / Görevler
2024 - Devam Ediyor
2024 - Devam EdiyorDoç. Dr.
Orta Doğu Teknik Üniversitesi, Fen Edebiyat Fakültesi, Biyolojik Bilimler Bölümü
2021 - 2024
2021 - 2024Dr. Öğr. Üyesi
Orta Doğu Teknik Üniversitesi, Fen Edebiyat Fakültesi, Biyolojik Bilimler Bölümü
2020 - 2021
2020 - 2021Dr. Öğr. Üyesi
Orta Doğu Teknik Üniversitesi, Fen Edebiyat Fakültesi, Biyolojik Bilimler Bölümü
Makaleler
Tümü (34)
SCI-E, SSCI, AHCI (29)
SCI-E, SSCI, AHCI, ESCI (31)
ESCI (2)
Scopus (32)
TRDizin (1)
Diğer Yayınlar (1)
2025
20251. A Roadmap for the Future of Systems Biology in Cancer Research
Wiley H. S., Lopez C. F., Rodin A. S., Rockne R. C., Yankeelov T. E., Sauro H. M., et al.
CANCER RESEARCH
, cilt.85, sa.24, ss.4880-4889, 2025 (SCI-Expanded, Scopus)
2025
20252. Phenotypic plasticity including drug efflux drives reversible irinotecan resistance in LIM1215 colorectal cancer cells
Dilber T., Yalcin G. D., YILMAZ K., ACAR A.
FEBS LETTERS
, 2025 (SCI-Expanded, Scopus)
2025
20253. Epigenetic Heritability of Cell Plasticity Drives Cancer Drug Resistance through a One-to-Many Genotype-to-Phenotype Paradigm
Oliveira E. A., Milite S., Fernandez-Mateos J., Cresswell G. D., Yara-Romero E., Vlachogiannis G., et al.
CANCER RESEARCH
, cilt.85, sa.15, ss.2921-2938, 2025 (SCI-Expanded, Scopus)
2025
20254. Investigation of potential KRASG12D inhibitors: a comparative study between MRTX1133 and natural compounds via computational structural biology approaches.
Bostancioglu S. M., Acar A.
BMC research notes
, cilt.18, sa.1, ss.287, 2025 (ESCI, Scopus)
2025
20255. Endoglin mediates the tumor- and metastasis-promoting traits of stromal myofibroblasts in human breast carcinomas.
Okubo S., Mezawa Y., Wang Z., Acar A., Ito Y., Takano A., et al.
Molecular oncology
, 2025 (SCI-Expanded, Scopus)
2025
20256. Holistic precision wellness: Paving the way for next-generation precision medicine (ngPM) with AI, biomedical informatics, and clinical medicine
Mohammed S. G. A. A., Qoronfleh M. W., Acar A., Al-Dewik N. I.
FASEB BioAdvances
, cilt.7, sa.4, 2025 (ESCI, Scopus)
2025
20257. Benchmarking long-read structural variant calling tools and combinations for detecting somatic variants in cancer genomes
Aydin S. K., YILMAZ K., ACAR A.
SCIENTIFIC REPORTS
, cilt.15, sa.1, 2025 (SCI-Expanded, Scopus)
2025
20258. Colorectal cancer tumor grade segmentation: A new dataset and baseline results
Arslan D., Sehlaver S., Guder E., Temena M. A., Bahcekapili A., Ozdemir U., et al.
Heliyon
, cilt.11, sa.4, 2025 (SCI-Expanded, Scopus)
2024
20249. Characterization of dabrafenib-induced drug insensitivity via cellular barcoding and collateral sensitivity to second-line therapeutics
Baygin R. C., Yilmaz K. C., ACAR A.
Scientific Reports
, cilt.14, sa.1, 2024 (SCI-Expanded, Scopus)
2024
202410. Covalent docking-based virtual screening and molecular dynamics simulations identify C02b as a potential KRAS(G12C) inhibitor
Merve Bostancioglu S., Acar A.
Tumor Discovery , cilt.4, sa.1, ss.1-10, 2024 (Hakemli Dergi)
2024
202411. Tumor evolution metrics predict recurrence beyond 10 years in locally advanced prostate cancer
Fernandez-Mateos J., Cresswell G. D., Trahearn N., Webb K., Sakr C., Lampis A., et al.
Nature Cancer
, cilt.5, sa.9, ss.1334-1351, 2024 (SCI-Expanded, Scopus)
2024
202412. Exploiting Matrix Stiffness to Overcome Drug Resistance
Aydin H. B., ÖZÇELİKKALE A., ACAR A.
ACS BIOMATERIALS SCIENCE & ENGINEERING
, cilt.10, sa.8, ss.4682-4700, 2024 (SCI-Expanded, Scopus)
2024
202413. Optimizing cancer therapy: a review of the multifaceted effects of metronomic chemotherapy
Basar O. Y., Mohammed S., Qoronfleh M. W., ACAR A.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
, cilt.12, 2024 (SCI-Expanded, Scopus)
2024
202414. Current Technologies and Future Perspectives in Immunotherapy towards a Clinical Oncology Approach
Adhikary S., Pathak S., Palani V., ACAR A., Banerjee A., Al-Dewik N. I., et al.
BIOMEDICINES
, cilt.12, sa.1, 2024 (SCI-Expanded, Scopus)
2024
202415. Tumor-Microenvironment-on-Chip Platform for Assessing Drug Response in 3D Dynamic Culture
Aydin H. B., Moon H., Han B., ÖZÇELİKKALE A., ACAR A.
Methods in molecular biology (Clifton, N.J.)
, cilt.2764, ss.265-278, 2024 (Scopus)
2023
202316. Investigation of evolutionary dynamics for drug resistance in 3D spheroid model system using cellular barcoding technology
Yalcin G. D., Yilmaz K. C., DİLBER T., ACAR A.
PLoS ONE
, cilt.18, sa.9 September, 2023 (SCI-Expanded, Scopus)
2023
202317. Integrative profiling of CEACAM1 in different malignancies with implications on the SARS-CoV-2 infection genes ACE2 and TMPRSS2
Acar A.
Hacettepe Journal of Biology and Chemistry
, cilt.51, sa.2, ss.1-10, 2023 (TRDizin)
2023
202318. Editorial: Cancer evolution
Ermini L., Mallo D., Kleftogiannis D., ACAR A.
FRONTIERS IN GENETICS
, cilt.14, 2023 (SCI-Expanded, Scopus)
2023
202319. Pan-Cancer Analysis of the COVID-19 Causal Gene SLC6A20
ACAR A.
ACS OMEGA
, cilt.8, sa.14, ss.13153-13161, 2023 (SCI-Expanded, Scopus)
2023
202320. Immune selection determines tumor antigenicity and influences response to checkpoint inhibitors
Zapata L., Caravagna G., Williams M. J., Lakatos E., AbdulJabbar K., Werner B., et al.
NATURE GENETICS
, cilt.55, sa.3, ss.451-460, 2023 (SCI-Expanded, Scopus)
2023
202321. Identification of collateral sensitivity and evolutionary landscape of chemotherapy-induced drug resistance using cellular barcoding technology
Danisik N., Yilmaz K. C., ACAR A.
Frontiers in Pharmacology
, cilt.14, 2023 (SCI-Expanded, Scopus)
2022
202222. Increased TRIM31 gene expression is positively correlated with SARS-CoV-2 associated genes TMPRSS2 and TMPRSS4 in gastrointestinal cancers
Temena M. A., ACAR A.
SCIENTIFIC REPORTS
, cilt.12, sa.1, 2022 (SCI-Expanded, Scopus)
2021
202123. Inhibition of Wnt signalling by Notch via two distinct mechanisms
Acar A., Hidalgo-Sastre A., Leverentz M. K., Mills C. G., Woodcock S., Baron M., et al.
SCIENTIFIC REPORTS
, cilt.11, sa.1, 2021 (SCI-Expanded, Scopus)
2020
202024. Systems Biology and Experimental Model Systems of Cancer
Yalcin G. D., Danisik N., Baygin R. C., Acar A.
JOURNAL OF PERSONALIZED MEDICINE
, cilt.10, sa.4, ss.1-12, 2020 (SCI-Expanded, Scopus)
2020
202025. Subclonal reconstruction of tumors by using machine learning and population genetics
Caravagna G., Heide T., Williams M. J., Zapata L., Nichol D., Chkhaidze K., et al.
NATURE GENETICS
, cilt.52, sa.9, ss.898-919, 2020 (SCI-Expanded, Scopus)
2020
202026. Exploiting evolutionary steering to induce collateral drug sensitivity in cancer
Acar A., Nichol D., Fernandez-Mateos J., Cresswell G. D., Barozzi I., Hong S. P., et al.
NATURE COMMUNICATIONS
, cilt.11, sa.1, 2020 (SCI-Expanded, Scopus)
2019
201927. Evolutionary dynamics of residual disease in human glioblastoma
Spiteri I., Caravagna G., Cresswell G. D., Vatsiou A., Nichol D., ACAR A., et al.
ANNALS OF ONCOLOGY
, cilt.30, sa.3, ss.456-463, 2019 (SCI-Expanded, Scopus)
2018
201828. The Spatiotemporal Evolution of Lymph Node Spread in Early Breast Cancer
Barry P., Vatsiou A., Spiteri I., Nichol D., Cresswell G. D., ACAR A., et al.
CLINICAL CANCER RESEARCH
, cilt.24, sa.19, ss.4763-4770, 2018 (SCI-Expanded, Scopus)
2016
201629. A Role for Notch Signalling in Breast Cancer and Endocrine Resistancesssss
ACAR A., Simoes B. M., Clarke R. B., Brennan K.
STEM CELLS INTERNATIONAL
, cilt.2016, 2016 (SCI-Expanded, Scopus)
2015
201530. Anti-estrogen Resistance in Human Breast Tumors Is Driven by JAG1-NOTCH4-Dependent Cancer Stem Cell Activity
Simoes B. M., O'Brien C. S., Eyre R., Silva A., Yu L., Sarmiento-Castro A., et al.
CELL REPORTS
, cilt.12, sa.12, ss.1968-1977, 2015 (SCI-Expanded, Scopus)
2015
201531. TGF-beta receptor type-2 expression in cancer-associated fibroblasts regulates breast cancer cell growth and survival and is a prognostic marker in pre-menopausal breast cancer
Busch S., ACAR A., Magnusson Y., Gregersson P., Ryden L., Landberg G.
ONCOGENE
, cilt.34, sa.1, ss.27-38, 2015 (SCI-Expanded, Scopus)
2012
201232. Dishevelled limits Notch signalling through inhibition of CSL
Collu G. M., Hidalgo-Sastre A., ACAR A., Bayston L., Gildea C., Leverentz M. K., et al.
DEVELOPMENT
, cilt.139, sa.23, ss.4405-4415, 2012 (SCI-Expanded, Scopus)
2011
201133. Experimental Generation of Carcinoma-Associated Fibroblasts (CAFs) from Human Mammary Fibroblasts
Polanska U. M., ACAR A., Orimo A.
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
, sa.56, 2011 (SCI-Expanded, Scopus)
2010
201034. Autocrine TGF-beta and stromal cell-derived factor-1 (SDF-1) signaling drives the evolution of tumor-promoting mammary stromal myofibroblasts
Kojima Y., ACAR A., Eaton E. N., Mellody K. T., Scheel C., Ben-Porath I., et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
, cilt.107, sa.46, ss.20009-20014, 2010 (SCI-Expanded, Scopus)
Kitaplar
2024
20241. Patient-Derived Organoids: Past, Present, and Future
Acar A.
Cancers in Different Conditions, Cancer Research Methods and Diagnosis: An Interdisciplinary Approach, Nima Rezaei, Editör, Springer, London/Berlin , London, ss.187-200, 2024
2024
20242. Tumor-Microenvironment-on-Chip Platform for Assessing Drug Response in 3D Dynamic Culture
Aydin H. B., Moon H., Han B., Ozcelikkale A., Acar A.
3D Cell Culture, Zuzana Sumbalova Koledova, Editör, Springer Nature, London, ss.265-278, 2024
Bilimsel Dergilerdeki Faaliyetler
2023 - Devam Ediyor
2023 - Devam EdiyorFrontiers in Systems Biology
Özel Sayı Editörü
2021 - 2023
2021 - 2023FRONTIERS IN GENETICS
Özel Sayı Editörü
Bilimsel Kuruluşlardaki Üyelikler / Görevler
2023 - Devam Ediyor
2023 - Devam EdiyorCOST
Üye
2022 - Devam Ediyor
2022 - Devam EdiyorCOST
Üye
2022 - Devam Ediyor
2022 - Devam EdiyorCOST
Üye
2021 - Devam Ediyor
2021 - Devam Ediyor
NIH/NCI Cancer Systems Biology Consortium
Asosiye Üye
2021 - Devam Ediyor
2021 - Devam EdiyorMOKAD
Üye
2021 - Devam Ediyor
2021 - Devam EdiyorEACR
Üye
2021 - 2022
2021 - 2022COST
Üye
Bilimsel Yayınlarda Hakemlikler
Aralık 2022
Aralık 2022FRONTIERS IN ONCOLOGY
SCI-E Kapsamındaki Dergi
Aralık 2022
Aralık 2022FRONTIERS IN ONCOLOGY
SCI-E Kapsamındaki Dergi
Kasım 2022
Kasım 2022FRONTIERS IN ONCOLOGY
SSCI Kapsamındaki Dergi
Ekim 2022
Ekim 2022FRONTIERS IN ONCOLOGY
SCI-E Kapsamındaki Dergi
Temmuz 2022
Temmuz 2022VIRUS RESEARCH
SCI-E Kapsamındaki Dergi
Haziran 2022
Haziran 2022FRONTIERS IN ECOLOGY AND EVOLUTION
SCI-E Kapsamındaki Dergi
Mart 2022
Mart 2022FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
SCI-E Kapsamındaki Dergi
Mart 2022
Mart 2022SCIENTIFIC REPORTS
SCI-E Kapsamındaki Dergi
Şubat 2022
Şubat 2022FRONTIERS IN ONCOLOGY
SCI-E Kapsamındaki Dergi
Ocak 2022
Ocak 2022FRONTIERS IN ONCOLOGY
SCI-E Kapsamındaki Dergi
Ocak 2022
Ocak 2022FRONTIERS IN ONCOLOGY
SCI-E Kapsamındaki Dergi
Ocak 2022
Ocak 2022FRONTIERS IN ONCOLOGY
SCI-E Kapsamındaki Dergi
Ocak 2022
Ocak 2022FRONTIERS IN ONCOLOGY
SCI-E Kapsamındaki Dergi
Ekim 2021
Ekim 2021FRONTIERS IN GENETICS
SCI-E Kapsamındaki Dergi
Mayıs 2021
Mayıs 2021SCIENTIFIC REPORTS
SCI-E Kapsamındaki Dergi
Nisan 2021
Nisan 2021FRONTIERS IN ONCOLOGY
SCI Kapsamındaki Dergi
Ocak 2021
Ocak 2021TUMOR BIOLOGY
SCI Kapsamındaki Dergi
Ocak 2021
Ocak 2021Turkish Journal of Biochemistry
Diğer Dergiler
Mart 2020
Mart 2020SCIENTIFIC REPORTS
SCI Kapsamındaki Dergi
Bilimsel Projelerde Hakemlikler
Aralık 2020
Aralık 2020TÜBİTAK Projesi
2219 - Yurt Dışı Doktora Sonrası Araştırma Burs Programı, Orta Doğu Teknik Üniversitesi, Türkiye
Ödüller
Şubat 2024
Şubat 2024
British Council Study in the UK Bilim ve Sürdürülebilirlik Ödülü
British Council
Temmuz 2022
Temmuz 2022
Aydin Dogan Foundation Ozlem Tureci & Ugur Sahin Molecular Biology and Genetics Research Award
Aydin Dogan Vakfi
Temmuz 2022
Temmuz 2022
Molecular Cancer Research Association Award for Basic Cancer Researcher of the Year
Molecular Cancer Research Association
Aralık 2021
Aralık 20212021 TÜBA-Üstün Başarılı Genç Bilim İnsanı Ödülü (GEBİP)
Türkiye Bilimler Akademisi (Tüba)