Evolutionary dynamics of residual disease in human glioblastoma


Spiteri I., Caravagna G., Cresswell G. D. , Vatsiou A., Nichol D., ACAR A. , ...More

ANNALS OF ONCOLOGY, vol.30, no.3, pp.456-463, 2019 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 30 Issue: 3
  • Publication Date: 2019
  • Doi Number: 10.1093/annonc/mdy506
  • Title of Journal : ANNALS OF ONCOLOGY
  • Page Numbers: pp.456-463

Abstract

Background Glioblastoma is the most common and aggressive adult brain malignancy against which conventional surgery and chemoradiation provide limited benefit. Even when a good treatment response is obtained, recurrence inevitably occurs either locally (approximate to 80%) or distally (approximate to 20%), driven by cancer clones that are often genomically distinct from those in the primary tumour. Glioblastoma cells display a characteristic infiltrative phenotype, invading the surrounding tissue and often spreading across the whole brain. Cancer cells responsible for relapse can reside in two compartments of residual disease that are left behind after treatment: the infiltrated normal brain parenchyma and the sub-ventricular zone. However, these two sources of residual disease in glioblastoma are understudied because of the difficulty in sampling these regions during surgery.