A Role for Notch Signalling in Breast Cancer and Endocrine Resistancesssss

ACAR A., Simoes B. M., Clarke R. B., Brennan K.

STEM CELLS INTERNATIONAL, vol.2016, 2016 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Review
  • Volume: 2016
  • Publication Date: 2016
  • Doi Number: 10.1155/2016/2498764
  • Journal Name: STEM CELLS INTERNATIONAL
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Middle East Technical University Affiliated: Yes

Abstract

Over the past decade, there has been growing interest in the Notch signalling pathway within the breast cancer field. This interest stemmed initially from the observation that Notch signalling is aberrantly activated in breast cancer and its effects on various cellular processes including proliferation, apoptosis, and cancer stem cell activity. However more recently, elevated Notch signalling has been correlated with therapy resistance in oestrogen receptor-positive breast cancer. As a result, inhibiting Notch signalling with therapeutic agents is being explored as a promising treatment option for breast cancer patients.