A Role for Notch Signalling in Breast Cancer and Endocrine Resistancesssss


ACAR A. , Simoes B. M. , Clarke R. B. , Brennan K.

STEM CELLS INTERNATIONAL, cilt.2016, 2016 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 2016
  • Basım Tarihi: 2016
  • Doi Numarası: 10.1155/2016/2498764
  • Dergi Adı: STEM CELLS INTERNATIONAL

Özet

Over the past decade, there has been growing interest in the Notch signalling pathway within the breast cancer field. This interest stemmed initially from the observation that Notch signalling is aberrantly activated in breast cancer and its effects on various cellular processes including proliferation, apoptosis, and cancer stem cell activity. However more recently, elevated Notch signalling has been correlated with therapy resistance in oestrogen receptor-positive breast cancer. As a result, inhibiting Notch signalling with therapeutic agents is being explored as a promising treatment option for breast cancer patients.