Publications & Works

Publication Network
Journal articles indexed in SCI, SSCI, and AHCI 21

1. Phosphorylation of SNAP-25 at Ser187 is enhanced following its cleavage by Botulinum Neurotoxin Serotype A, promoting the dominant-negative effect of the resulting fragment

Koc D., EZGİN S., Kavakli E., Kota K. P., Sen E., Mahone C., et al.
PLOS Pathogens , vol.21, no.10 October, 2025 (SCI-Expanded) Creative Commons License identifier identifier

2. Editorial: Studying rare diseases using induced pluripotent stem cell (iPSC)-based model systems

Francis K. R., Chen G., KİRİŞ E.
Frontiers in Cell and Developmental Biology , vol.13, 2025 (SCI-Expanded) Creative Commons License identifier identifier identifier

3. Tirbanibulin (KX2-391) analog KX2-361 inhibits botulinum neurotoxin serotype A mediated SNAP-25 cleavage in pre- and post-intoxication models in cells

Koc D., Ibis K., Besarat P., Banoğlu E., Kiriş E.
DRUG DEVELOPMENT RESEARCH , vol.85, no.6, 2024 (SCI-Expanded) identifier identifier identifier

4. Generation and characterization of human induced pluripotent stem cell line METUi002-A from a patient with primary familial brain calcification (PFBC) carrying a heterozygous mutation (c.687dupT (p.Val230CysfsTer28)) in the SLC20A2 gene.

Begentas O. C., Koc D., Sendur N. K., Besarat P., Ezgin S., Temel M., et al.
Stem cell research , vol.72, pp.103226, 2023 (SCI-Expanded) Creative Commons License identifier identifier identifier

5. TrkA-cholinergic signaling modulates fear encoding and extinction learning in PTSD-like behavior.

Yanpallewar S., Tomassoni-Ardori F., Palko M. E., Hong Z., Kiris E., Becker J., et al.
Translational psychiatry , vol.12, no.1, pp.111, 2022 (SCI-Expanded) identifier identifier identifier

6. Screening of a Focused Ubiquitin-Proteasome Pathway Inhibitor Library Identifies Small Molecules as Novel Modulators of Botulinum Neurotoxin Type A Toxicity.

Sen E., Kota K. P., Panchal R. G., Bavari S., Kiris E.
Frontiers in pharmacology , vol.12, pp.763950, 2021 (SCI-Expanded) Creative Commons License Sustainable Development identifier identifier identifier

7. Generation and characterization of human induced pluripotent stem cell line METUi001-A from a 25-year-old male patient with relapsing-remitting multiple sclerosis

Begentaş O. C., Koc D., Yurtogullari S., Temel M., Akcali K. C., Demirkaya S., et al.
Stem Cell Research , vol.53, 2021 (SCI-Expanded) Creative Commons License Sustainable Development identifier identifier identifier

8. New Steroidal 4-Aminoquinolines Antagonize Botulinum Neurotoxin Serotype A in Mouse Embryonic Stem Cell Derived Motor Neurons in Postintoxication Model.

Konstantinović J., Kiris E., Kota K., Kugelman-Tonos J., Videnović M., Cazares L., et al.
Journal of medicinal chemistry , vol.61, pp.1595-1608, 2018 (SCI-Expanded) identifier identifier identifier

9. Deubiquitinating enzyme VCIP135 dictates the duration of botulinum neurotoxin type A intoxication.

Tsai Y., Kotiya A., Kiris E., Yang M., Bavari S., Tessarollo L., et al.
Proceedings of the National Academy of Sciences of the United States of America , vol.114, 2017 (SCI-Expanded) Creative Commons License identifier identifier identifier

10. Paclitaxel suppresses Tau-mediated microtubule bundling in a concentration-dependent manner.

Choi M., Chung P., Song C., Miller H., Kiris E., Li Y., et al.
Biochimica et biophysica acta. General subjects , vol.1861, pp.3456-3463, 2017 (SCI-Expanded) identifier identifier identifier

11. RanBPM (RanBP9) regulates mouse c-Kit receptor level and is essential for normal development of bone marrow progenitor cells.

Puverel S., Kiris E., Singh S., Klarmann K., Coppola V., Keller J., et al.
Oncotarget , vol.7, pp.85109-85123, 2016 (SCI-Expanded) identifier identifier identifier

12. Phosphatase Inhibitors Function as Novel, Broad Spectrum Botulinum Neurotoxin Antagonists in Mouse and Human Embryonic Stem Cell-Derived Motor Neuron-Based Assays.

Kiris E., Nuss J., Stanford S., Wanner L., Cazares L., Maestre M., et al.
PloS one , vol.10, 2015 (SCI-Expanded) identifier identifier identifier

13. SRC family kinase inhibitors antagonize the toxicity of multiple serotypes of botulinum neurotoxin in human embryonic stem cell-derived motor neurons.

Kiris E., Burnett J., Nuss J., Wanner L., Peyser B., Du H., et al.
Neurotoxicity research , vol.27, pp.384-98, 2015 (SCI-Expanded) identifier identifier identifier

14. A high content imaging assay for identification of Botulinum neurotoxin inhibitors.

Kota K., Soloveva V., Wanner L., Gomba G., Kiris E., Panchal R., et al.
Journal of visualized experiments : JoVE , 2014 (SCI-Expanded) identifier identifier identifier

15. TrkA in vivo function is negatively regulated by ubiquitination.

Kiris E., Wang T., Yanpallewar S., Dorsey S., Becker J., Bavari S., et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience , vol.34, pp.4090-8, 2014 (SCI-Expanded) Creative Commons License identifier identifier identifier

16. Recent developments in cell-based assays and stem cell technologies for botulinum neurotoxin research and drug discovery.

Kiris E., Kota K., Burnett J., Soloveva V., Kane C., Bavari S.
Expert review of molecular diagnostics , vol.14, pp.153-68, 2014 (SCI-Expanded) Creative Commons License identifier identifier identifier

17. Recent advances in botulinum neurotoxin inhibitor development.

Kiris E., Burnett J., Kane C., Bavari S.
Current topics in medicinal chemistry , vol.14, pp.2044-61, 2014 (SCI-Expanded) identifier identifier identifier

18. Embryonic stem cell-derived motoneurons provide a highly sensitive cell culture model for botulinum neurotoxin studies, with implications for high-throughput drug discovery.

Kiris E., Nuss J., Burnett J., Kota K., Koh D., Wanner L., et al.
Stem cell research , vol.6, pp.195-205, 2011 (SCI-Expanded) identifier identifier identifier

19. Combinatorial Tau pseudophosphorylation: markedly different regulatory effects on microtubule assembly and dynamic instability than the sum of the individual parts.

Kiris E., Ventimiglia D., Sargin M., Gaylord M., Altinok A., Rose K., et al.
The Journal of biological chemistry , vol.286, pp.14257-70, 2011 (SCI-Expanded) Creative Commons License identifier identifier identifier

20. Human microtubule-associated-protein tau regulates the number of protofilaments in microtubules: a synchrotron x-ray scattering study.

Choi M., Raviv U., Miller H., Gaylord M., Kiris E., Ventimiglia D., et al.
Biophysical journal , vol.97, pp.519-27, 2009 (SCI-Expanded) Creative Commons License identifier identifier identifier

21. Model based dynamics analysis in live cell microtubule images.

Altinok A., Kiris E., Peck A., Feinstein S., Wilson L., Manjunath B., et al.
BMC cell biology , 2007 (SCI-Expanded) identifier identifier identifier
Articles Published in Other Journals 1

1. Astrocytes in Primary Familial Brain Calcification (PFBC): Emphasis on the Importance of Induced Pluripotent Stem Cell-Derived Human Astrocyte Models

Kavakli E., Gul N., BEGENTAŞ O. C., KİRİŞ E.
Advances in experimental medicine and biology , vol.1479, pp.19-38, 2025 (Scopus) identifier identifier
Papers Presented at Peer-Reviewed Scientific Conferences 10

1. Amyloid beta peptit oligomerlerinin (Aβ(1-42)) in vitro muamelesinin TrkB sinyali artırılmış kök hücre temelli kortikal nöronlar üzerindeki etkisinin doğal kortikal nöronlar ile kıyaslamalı olarak araştırılması

Beşarat P., EZGİN S., KİRİŞ E.
19. Ulusal Sinirbilim Kongresi, Online, Turkey, 21 - 23 November 2021, (Summary Text)

2. Fare Kök Hücrelerinden Başkalaştırılmış Bazal Ön Beyin Kolinerjik Nöronlarda TrkA Sinyalinin Artırılmasının in vitro Alzheimer Hastalığını Nörodejeneratif Sürecine Karşı Etkisinin Kontrollere Kıyasla Araştırılması

EZGİN S., Beşarat P., KİRİŞ E.
19. Ulusal Sinirbilim Kongresi, Online, Turkey, 21 - 23 November 2021

3. Kinase and Phosphatase Signaling Pathways Serve as Essential Host Factors for Botulinum Neurotoxins and are Targets for Pan-Serotype Drug Development

Nuss J., KİRİŞ E., Soloveva V., Duplantier A., Kane C.
Interagency Botulism Research Coordinating Committee Meeting, Fredericia, Denmark, 25 October 2015 - 28 October 2016

4. New Steroidal 4-aminoquinolines Antagonize BoNT/A in mES-MNs in Post-intoxication Model

Konstantinovic J. M., KİRİŞ E., Zlatovic M. V., Bavari S., Solaja B.
XXIV EFMC International Symposium on Medicinal Chemistry, Manchester, United Kingdom, 28 August - 01 September 2016, (Summary Text)

5. The effect of human microtubule associated protein tau on the assembly structure of microtubules and its ionic strength dependence

Choi M. C., Raviv U., Miller H. P., Gaylord M., KİRİŞ E., Ventimiglia D., et al.
American Physical Society, APS March Meeting 2010, Portland, United States Of America, 15 - 19 March 2010

6. Quantification of dynamic behavior of microtubules in living cells using novel computational methods

Altinok A., KİRİŞ E., Sargin M. E., Wilson L., Feinstein S. C., Manjunath B. S., et al.
38th Annual Meeting of Society for Neuroscience (SfN), Washington, Kiribati, 15 - 19 November 2008

7. Novel tracking and analysis software for dynamic cell processes tau phosphorylation and the regulation of microtubule dynamics

KİRİŞ E., Gaylord M. R., Ventimiglia D., Altinok A., Sargin M. E., Rose K., et al.
16th Annual Research Symposium, Neuroscience Research Institute, University of Clifornia, Santa Barbara, Santa-Barbara, Honduras, 09 May 2008

8. Syncrotron X ray Diffraction Study on the Size Distribution and the Mechanical Stability of Microtubules by Microtubule Associated Protein MAP Tau

Choi M. C., Raviv U., Miller H. P., Gaylord M., KİRİŞ E., Ventimiglia D., et al.
American Physical Society (APS) Meeting, New Orleans, United States Of America, 10 - 14 March 2008

9. Effects of combinatorial tau pseudophosphorylation upon its aggregation behavior in vitro

KİRİŞ E., Ventimiglia D., Gaylord M. R., Chen M., Medina H., Jordan M. A., et al.
18th Annual International Light Scattering Colloquium, Santa-Barbara, Honduras, 17 - 18 October 2007

10. Tracing microtubules in live cell images

Sargin M. E., Altinok A., KİRİŞ E., Feinstein S. C., Wilson L., Rose K., et al.
2007 4TH IEEE INTERNATIONAL SYMPOSIUM ON BIOMEDICAL IMAGING : MACRO TO NANO, VOLS 1-3, Darlington, United Kingdom, 12 - 15 April 2007, (Full Text)
Books 4

1. Astrocytes in Primary Familial Brain Calcification (PFBC): Emphasis on the Importance of Induced Pluripotent Stem Cell-Derived Human Astrocyte Models

Kavaklı E., Gül N., BEGENTAŞ O. C., KİRİŞ E.
in: Advances in Experimental Medicine and Biology, Turksen Kursad, Editor, Springer, Cham, Cham, pp.1-20, 2025

2. Establishment of Human Induced Pluripotent Stem Cells from Multiple Sclerosis Patients

Begentaş O. C., Koç D., Kiriş E.
in: Methods in Molecular Biology, Induced Pluripotent Stem Cells and Human Disease, TURKSEN KURSAD, Editor, Humana Press, New York, pp.43-67, 2022 Creative Commons License Sustainable Development

3. Human-Induced Pluripotent Stem Cell–Based Models for Studying Sex-Specific Differences in Neurodegenerative Diseases

Kiriş E.
in: Advances in Experimental Medicine and Biology, Turksen,Kursad, Editor, Springer Nature, Zug, pp.57-88, 2021 Creative Commons License

4. Quantitative Analysis of MAP-Mediated Regulation of Microtubule Dynamic Instability In Vitro—Focus on Tau

Kiriş E., Ventimiglia D., Feinstein S. C.
in: METHODS IN CELL BIOLOGY, Leslie Wilson,John J. Correia, Editor, Elsevier Science, Oxford/Amsterdam , Massachusetts, pp.481-503, 2010
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37

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22

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367

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11

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387

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11

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570

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14

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20

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5

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10
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