Prof. PINAR ÇALIK

Academic Titles

2006 - Continues Professor

Middle East Technical University, Faculty of Engineering, Department of Chemical Engineering
2000 - 2006 Associate Professor

Middle East Technical University, Faculty of Engineering, Department of Chemical Engineering
1998 - 2000 Lecturer

Ankara University, Faculty Of Engıneerıng, Department Of Chemıstry Engıneerıng
1995 - 1998 Research Assistant

Ankara University, Mühendislik Fakültesi, Kimya Mühendisliği Bölümü
1993 - 1994 Expert

Ankara University, Faculty Of Pharmacy, Department Of Pharmaceutıcal Technology

Managerial Experience

2018 - 2024 Head of Department

Middle East Technical University, Faculty Of Engineering, Department Of Chemical Engineering

Non Academic Experience

2006 - Continues Professor

METU
2002 - Continues Associate Professor (Promotion)

METU
1999 - Continues Associate Professor (Title)

METU
2000 - 2002 Assistant Professor

METU
2000 - 2000 Assistant Professor

METU
2000 - 2000 Associate Professor (Title)

METU

Advising Theses

Methodologies for prediction of transcription factors in transcriptional regulatory mechanisms in biocatalysis of reactions in yeast central pathways

ÇALIK P. (Advisor)

O.ULAŞ(Student), Postgraduate, 2022
Effects of metabolic engineering of ethanol utilization pathway in Pichia pastoris on recombinant protein production and transcription levels in central metabolism

Çalık P. (Advisor)

İ.DAYANKAÇ(Student), Postgraduate, 2021
Analysis and characterization of the Pichia pastoris secretome for pharmaceutical protein production

Çalık P., KOKU H.

H.PINAR(Student), Postgraduate, 2019
Design and construction of double promoter systems andtheir use in pharmaceutical protein production inP. pastoris

Çalık P. (Advisor)

İ.DEMİR(Student), Postgraduate, 2019
Transcriptional engineering of Pichia pastoris Alcohol dehydrogenase 2 and Alcohol oxidase 1 promoters for recombinant protein production

ÇALIK P. (Advisor)

B.GÜNDÜZ(Student), Doctorate, 2018
Therapeutic protein production and its separation by zeolitic imidazolate framework–8 adsorbent

Kalıpçılar H. (Co-Advisor), Çalık P.

Y.AKGÜN(Student), Postgraduate, 2018
Metabolic engineering with a novel promoter in Pichia pastoris for recombinant human growth hormone production: Effects of oxygen transfer conditions

ÇALIK P. (Advisor)

Ö.KALENDER(Student), Postgraduate, 2018
Recombinant human growth hormone production under double promoters by Pichia pastoris

ÇALIK P. (Advisor)

D.YALÇINKAYA(Student), Postgraduate, 2017
Effect of signal sequences and promoters in recombinant extracellular protein production by Pichia pastoris

ÇALIK P. (Advisor)

A.MASSAHI(Student), Doctorate, 2017
Separation and purification of recombinant proteins by using ultrafiltration memranes

ÇULFAZ EMECEN P. Z. (Co-Advisor), ÇALIK P. (Co-Advisor)

B.Akcan(Student), Postgraduate, 2017
Granulocyte-colony stimulating factor analog production by recombinant Escherichia coli

ÇALIK P. (Advisor)

O.ERSOY(Student), Postgraduate, 2017
Separation and purification of recombinant proteins by using ultrafiltration membranes

ÇALIK P. (Co-Advisor), ÇULFAZ EMECEN P. Z. (Co-Advisor)

B.AKCAN(Student), Postgraduate, 2017
Enhanced recombinant human growth hormone production by synchronous populations of two different strains of Pichia pastoris under GAP promoter

ÇALIK P. (Advisor)

D.HÜCCETOĞULLARI(Student), Postgraduate, 2016
Defined and complex medium based feeding strategy development for recombinant human growth hormone production by P. pastoris under gap promoter

ÇALIK P. (Advisor)

B.HOXHA(Student), Postgraduate, 2016
The effect of oxygen transfer conditions on recombinant glucose isomerase production by Pichia pastoris under glyceraldehyde-3-phosphate dehydrogenase promoter

ÇALIK P. (Advisor)

H.GÜNEŞ(Student), Postgraduate, 2015
A comparative study for the production of recombinant intracellular glucose isomerase by Escherichia coli and Pichia pastoris

ÇALIK P. (Advisor)

S.YAMAN(Student), Postgraduate, 2014
Glucose-based feeding strategy development in recombinant human growth hormone production by Pichia pastoris for semi-batch bioreactor operation

ÇALIK P. (Advisor)

A.KESKİN(Student), Postgraduate, 2014
Investigation of thermostable recombinant glucose isomerase production by sucrose utilizing Escherichia coli

ÇALIK P. (Advisor)

B.AKDAĞ(Student), Postgraduate, 2013
Effects of co-carbon sources in recombinant human erythropoitein production by pichia pastoris

ÇALIK P. (Advisor)

Ş.Melda(Student), Postgraduate, 2013
Effects of CO-carbon sources in recombinant human erythropoietin production by pichia pastoris

ÇALIK P. (Advisor)

Ş.MELDA(Student), Postgraduate, 2013
Human growth hormone production by metabolically engineered B. subtilis: Feeding strategy development

ÇALIK P. (Advisor)

B.GÖKBUDAK(Student), Postgraduate, 2013
Comparison of human growth hormone production performance of two different metabolically engineered Pichia pastoris

ÇALIK P. (Advisor)

H.Gül(Student), Postgraduate, 2012
Feeding strategy development for human growth hormone production by Pichia pastoris

ÇALIK P. (Advisor)

B.BOZKURT(Student), Postgraduate, 2012
Physiological and biochemical screening of different Turkish lentil cultivars under salt stress conditions

ÇALIK P. (Advisor)

F.Selin(Student), Postgraduate, 2012
Comparison of human growth hormone production performances of two different metabolically engineered Pichia pastoris

ÇALIK P. (Advisor)

H.GÜL(Student), Postgraduate, 2012
Metabological engineering of Pichia Pastoris for extracellular thermostable glucose isomerase production

ÇALIK P. (Advisor)

Ö.Ata(Student), Postgraduate, 2012
Metabolical engineering of Pichia pastoris for extracellular thermostable glucose isomerase production

ÇALIK P. (Advisor)

Ö.ATA(Student), Postgraduate, 2012
Recombinant transglutaminase production by metabolically engineered Pichia pastoris

ÇALIK P. (Advisor)

B.GÜNDÜZ(Student), Postgraduate, 2012
Extracellular recombinant human growth hormone production by pichia pastoris

ÇALIK P. (Advisor)

E.Boy(Student), Postgraduate, 2011
Bioprocess development for thermostable glucose isomerase production

ÇALIK P. (Advisor)

V.ANGARDİ(Student), Doctorate, 2011
Recombinant Pyrococcus furiosus extracellular alpha-amylase expression in Pichia pastoris

ÇALIK P. (Advisor)

E.BOY(Student), Postgraduate, 2011
Enzyme enhanced ultrafiltration for the resolution of racemic mandelic acid

ÇALIK P. (Co-Advisor), YILMAZ L. (Co-Advisor)

Ü.BADE(Student), Postgraduate, 2011
Effect of pH on erythropoietin production by recombinant Pichia pastoris in fed-batch operation

ÇALIK P. (Advisor)

E.ŞÜKRAN(Student), Postgraduate, 2010
Regulatory Gene Effects on Recombinant Human Growth Hormone Production by Bacillus subtilis

ÇALIK P. (Advisor)

M.ŞAHİN(Student), Postgraduate, 2010
Recombinant human growth hormone production by Pichia pastoris and determination of its interaction with peptide ligands

ÇALIK P. (Advisor)

B.İNANKUR(Student), Postgraduate, 2010
Exponential feeding strategy development for benzaldehyde lyase production by recombinant "Escherichia coli"

ÇALIK P. (Advisor)

H.TAŞPINAR(Student), Postgraduate, 2010
Novel bioconversion reactions for the syntheses of a-hydroxy ketones

ÇALIK P. (Advisor)

P.AYHAN(Student), Doctorate, 2009
Effects of carbon sources and feeding strategies on human growth hormone production by metabolically engineered Pichia pastoris

ÇALIK P. (Advisor)

E.AÇIK(Student), Postgraduate, 2009
Effects of pH on human growth hormone production by Pichia pastoris considering the expression levels of regulatory genes

ÇALIK P. (Advisor)

E.BAYRAKTAR(Student), Postgraduate, 2009
Feeding strategy development for benzaldehyde lyase production by recombinant Escherichia coli BL21

ÇALIK P. (Advisor)

H.LEVENT(Student), Postgraduate, 2008
Affinity chromatographic purification of recombinant human growth hormone

ÇALIK P. (Advisor)

O.BALCI(Student), Postgraduate, 2008
Bioprocess development for therapeutical protein production

ÇALIK P. (Advisor)

E.ÇELİK(Student), Doctorate, 2008
Recombinant therapeutic protease production by Bacillus sp.

ÇALIK P. (Co-Advisor), KOCABIYIK S. (Co-Advisor)

N.KORKMAZ(Student), Postgraduate, 2007
Extracellular recombinant human growth hormone production by Pichia pastoris

ÇALIK P. (Advisor)

M.ALİ(Student), Postgraduate, 2007
Investigation of bioprocess parameters for glucose isomerase production by Bacillus thermoantarcticus

ÇALIK P. (Advisor)

I.HAYKIR(Student), Postgraduate, 2007
Influence of oxygen transfer on benzaldehyde lyase production by recombinant Escherichia coli BL21(DE3) pLySs

ÇALIK P. (Advisor)

V.ANGARDİ(Student), Postgraduate, 2007
Serin alkali proteaz sentezini kontrol eden aspartik asit grubu amino asitlerin proteaz üretimine etkisinin araştırılması

ÇALIK P. (Advisor)

B.TOSUN(Student), Postgraduate, 2007
Chiral separations by enzyme enhanced ultrafiltration: Fractionation of racemic benzoin

ÇALIK P. (Co-Advisor), YILMAZ L. (Co-Advisor)

A.HANDE(Student), Postgraduate, 2006
Cloning and expression of benzaldehyde lyase gene from pseudomonas fluorescens biovar i in Pichia pastoris

ÇALIK P. (Advisor)

A.BÜYÜKSUNGUR(Student), Postgraduate, 2006
Comparison of benzaldehyde lyase production capacity in recombinant Escherichia coli and recombinant bacillus species

ÇALIK P. (Advisor)

H.KAYA(Student), Postgraduate, 2006
Cloning and expression ofbenzaldehydelyase from Pseudomonas fluorescens Biovar I in Pichia pastoris

ÇALIK P. (Advisor)

A.Büyüksungur(Student), Postgraduate, 2006
Obtaining durable enzyme powder via spray drying

ÇALIK P. (Co-Advisor), ULUDAĞ Y. (Co-Advisor)

A.NAMALDI(Student), Postgraduate, 2005
Effects of pH and feeding strategy on metabolite profiling of beta-lactamase producing Bacillus licheniformis

ÇALIK P. (Advisor)

N.İLERİ(Student), Postgraduate, 2005
Aromatic amino acid synthesis performance of Bacillus acidocaldarius

ÇALIK P. (Advisor)

P.KOCABAŞ(Student), Postgraduate, 2004
Determination of metabolic bottlenecks using reaction engineering principles in serine alkaline protease production by recombinant Bacillus sp.

ÇALIK P. (Advisor)

İ.ECE(Student), Postgraduate, 2004
Effects of bioreactor operation parameters on intracellular reaction rate distribution in beta-lactamase production by Bacillus species

ÇALIK P. (Advisor)

M.ARİFOĞLU(Student), Postgraduate, 2004
Bioprocess operation parameters for recombinant benzaldehyde lyase production

ÇALIK P. (Advisor)

P.YILGÖR(Student), Postgraduate, 2004
Comparative analysis of product and by-product distributions in defined and complex media in serine alkaline protease production by recombinant Bacillus subtilis

ÇALIK P. (Advisor)

C.OKTAR(Student), Postgraduate, 2003
Bioprocess desing parameters for beta-lactamase production by Bacillus species

ÇALIK P. (Advisor)

E.ÇELİK(Student), Postgraduate, 2003
Comparative analysis of product and by-product distributions in defined and complex media in serine alkaline protease production by recombinant Basillus subtilis

ÇALIK P. (Advisor)

C.Oktar(Student), Postgraduate, 2003
Fed-batch strategy development for serine alkaline protease production

ÇALIK P. (Advisor)

A.SİNEM(Student), Postgraduate, 2003
Bioprocess design parameters for beta-lactamase production by Bacillus species

ÇALIK P. (Advisor)

E.Çelik(Student), Postgraduate, 2003
Investigation of bioreactor operation conditions for serine alkaline protease production by Bacillus subtilis

ÇALIK P. (Advisor)

E.ÖZDEMİR(Student), Postgraduate, 2003
Rekombinant proteaz üretiminde biyoreaktör işletim parametrelerinin hücreiçi tepkime hızlarına ve verime etkisi

ÇALIK P. (Advisor)

E.BİLİR(Student), Postgraduate, 2002
Rekombinant bacillus türleri ile serin alkali proteaz üretimi için kompleks ortamda oksijen aktarımı etkilerinin araştırılması

ÇALIK P. (Advisor)

N.PEHLİVAN(Student), Postgraduate, 2001
Serin alkali proteaz geni SubC bacillus plasmidlerine klonlanarak rekombinant biyokatalizör ile alkali proteaz üretimi

ÇALIK P. (Advisor)

N.KALENDER(Student), Postgraduate, 2000

Academic and Administrative Experience

2006 - Continues Professor

2000 - 2006 Associate Professor

1998 - 2000 Lecturer

1995 - 1998 Research Assistant

1993 - 1994 Expert

2018 - 2024 Head of Department

2006 - Continues Professor

2002 - Continues Associate Professor (Promotion)

1999 - Continues Associate Professor (Title)

2000 - 2002 Assistant Professor

2000 - 2000 Assistant Professor

2000 - 2000 Associate Professor (Title)