Eğitim Bilgileri
2011 - 2018
2011 - 2018Doktora
İhsan Doğramacı Bilkent Üniversitesi, Fen Fakültesi, Moleküler Biyoloji Ve Genetik Bölümü, Türkiye
2007 - 2011
2007 - 2011Lisans
İhsan Doğramacı Bilkent Üniversitesi, Fen Fakültesi, Moleküler Biyoloji Ve Genetik Bölümü, Türkiye
Yabancı Diller
C1 İleri
C1 İleriİngilizce
Araştırma Alanları
Moleküler Biyoloji ve Genetik
Kanser Moleküler Biyolojisi
Akademik Unvanlar / Görevler
2020 - Devam Ediyor
2020 - Devam EdiyorÖğretim Görevlisi Dr.
Orta Doğu Teknik Üniversitesi, Enformatik Enstitüsü, Sağlık Bilişimi Anabilim Dalı
Yönetilen Tezler
2023
2023Yüksek Lisans
MECHANISMS OF SYNERGISTIC ANTITUMOR EFFECT OF NAPROXEN AND SORAFENIB IN HEPATOCELLULAR CARCINOMA
Kahraman D. C. (Eş Danışman), Muyan M.
E.AKAR(Öğrenci)
2022
2022Yüksek Lisans
IN VITRO AUTOCRINE SECRETION OF INFLAMMATORY CYTOKINES IN RESPONSE TO DRUG STRESS IN HCC AND LCSC POPULATIONS
Kahraman D. C. (Eş Danışman), Muyan M.
N.ECE(Öğrenci)
2021
2021Yüksek Lisans
BIOACTIVITY ANALYSIS OF NOVEL INDOLE DERIVATIVES ON HEPATOCELLULAR CARCINOMA AS SIRTUIN INHIBITORS
Kahraman D. C. (Eş Danışman), Muyan M.
B.BINARCI(Öğrenci)
SCI, SSCI ve AHCI İndekslerine Giren Dergilerde Yayınlanan Makaleler
2023
2023Design, synthesis, molecular docking studies and biological evaluation of thiazole carboxamide derivatives as COX inhibitors
Hawash M., Jaradat N., Abualhasan M., ŞÜKÜROĞLU M. K., Qaoud M. T., KAHRAMAN D. C., et al.
BMC Chemistry , cilt.17, sa.1, 2023 (SCI-Expanded)
2023
2023Novel indole-pyrazole hybrids as potential tubulin-targeting agents; Synthesis, antiproliferative evaluation, and molecular modeling studies
Hawash M., Ergun S. G., KAHRAMAN D. C., OLĞAÇ A., Hamel E., Cetin-Atalay R., et al.
Journal of Molecular Structure , cilt.1285, 2023 (SCI-Expanded)
2022
2022A new triazolothiadiazine derivative inhibits stemness and induces cell death in HCC by oxidative stress dependent JNK pathway activation
KAHRAMAN D. C., Guven E. B., Aytac P. S., Aykut G., Tozkoparan B., Atalay R. C.
SCIENTIFIC REPORTS , cilt.12, sa.1, 2022 (SCI-Expanded)
2022
2022Design and synthesis of novel substituted indole-acrylamide derivatives and evaluation of their anti-cancer activity as potential tubulin-targeting agents
Hawash M., KAHRAMAN D. C., OLĞAÇ A., Ergun S. G., Hamel E., Cetin-Atalay R., et al.
JOURNAL OF MOLECULAR STRUCTURE , cilt.1254, 2022 (SCI-Expanded)
2022
2022Low Density Granulocytes and Dysregulated Neutrophils Driving Autoinflammatory Manifestations in NEMO Deficiency
Yilmaz N. S., Eltan S. B., KAYAOĞLU B., Geckin B., Heredia R. J., Sefer A. P., et al.
JOURNAL OF CLINICAL IMMUNOLOGY , cilt.42, sa.3, ss.582-596, 2022 (SCI-Expanded)
2022
2022Context dependent isoform specific PI3K inhibition confers drug resistance in hepatocellular carcinoma cells.
Narci K., Kahraman D. C., Koyas A., Ersahin T., Tuncbag N., Atalay R. C.
BMC cancer , cilt.22, sa.1, ss.320, 2022 (SCI-Expanded)
2021
2021Synthesis of novel indole-isoxazole hybrids and evaluation of their cytotoxic activities on hepatocellular carcinoma cell lines
Hawash M., KAHRAMAN D. C., Ergun S. G., Cetin-Atalay R., BAYTAŞ S.
BMC CHEMISTRY , cilt.15, sa.1, 2021 (SCI-Expanded)
2021
2021Synthesis and biological evaluation of novel isoxazole-piperazine hybrids as potential anti-cancer agents with inhibitory effect on liver cancer stem cells
Ibis K., NALBAT E., ÇALIŞKAN B., KAHRAMAN D. C., Cetin-Atalay R., BANOĞLU E.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY , cilt.221, 2021 (SCI-Expanded)
2021
2021Induction of Apoptosis in Hepatocellular Carcinoma Cell Lines by Novel Indolylacrylamide Derivatives: Synthesis and Biological Evaluation
Hawash M., Kahraman D. C., Cetin-Atalay R., BAYTAŞ S.
CHEMISTRY & BIODIVERSITY , cilt.18, sa.5, 2021 (SCI-Expanded)
2021
2021MDeePred: Novel multi-channel protein featurization for deep learning-based binding affinity prediction in drug discovery
Rifaioglu A., Atalay R. C., KAHRAMAN D. C., DOĞAN T., Martin M., ATALAY M. V.
Bioinformatics , cilt.37, sa.5, ss.693-704, 2021 (SCI-Expanded)
2021
2021Transcriptome profiles associated with selenium-deficiency-dependent oxidative stress identify potential diagnostic and therapeutic targets in liver cancer cells
Gozen D., KAHRAMAN D. C., Narci K., Shehwana H., KONU KARAKAYALI Ö., Cetin-Atalay R.
TURKISH JOURNAL OF BIOLOGY , cilt.45, sa.2, ss.149-164, 2021 (SCI-Expanded)
2020
2020CXXC5 as an unmethylated CpG dinucleotide binding protein contributes to estrogen-mediated cellular proliferation.
Ayaz G., Razizadeh N., Yaşar P., Kars G., Kahraman D. C., Saatci Ö., et al.
Scientific reports , cilt.10, ss.5971, 2020 (SCI-Expanded)
2019
2019Targeting PI3K/Akt/mTOR Pathway Identifies Differential Expression and Functional Role of IL8 in Liver Cancer Stem Cell Enrichment
KAHRAMAN D. C., Kahraman T., Cetin-Atalay R.
MOLECULAR CANCER THERAPEUTICS , cilt.18, sa.11, ss.2146-2157, 2019 (SCI-Expanded)
2019
2019Synthesis, anticancer activity, toxicity evaluation and molecular docking studies of novel phenylaminopyrimidine-(thio)urea hybrids as potential kinase inhibitors.
Ture A., Kahraman D. C., Cetin-Atalay R., Helvacioglu S., Charehsaz M., KÜÇÜKGÜZEL İ.
Computational biology and chemistry , cilt.78, ss.227-241, 2019 (SCI-Expanded)
2018
2018Design, synthesis and biological evaluation of novel 1,3-diarylpyrazoles as cyclooxygenase inhibitors, antiplatelet and anticancer agents.
Inceler N., ÖZKAN Y., Turan N. N., Kahraman D. C., Cetin-Atalay R., BAYTAŞ S.
MedChemComm , cilt.9, sa.5, ss.795-811, 2018 (SCI-Expanded)
2017
2017Synthesis and biological evaluation of novel pyrazolic chalcone derivatives as novel hepatocellular carcinoma therapeutics.
Hawash M. M. A., Kahraman D. C., Eren F., Atalay R. C., BAYTAŞ S.
European journal of medicinal chemistry , cilt.129, ss.12-26, 2017 (SCI-Expanded)
2016
2016Quinoides and VEGFR2 TKIs influence the fate of hepatocellular carcinoma and its cancer stem cells.
Kahraman D. C., Hanquet G., Jeanmart L., Lanners S., Sramel P., Bohac A., et al.
MedChemComm , cilt.8, sa.1, ss.81-87, 2016 (SCI-Expanded)
2016
2016Phase and TV Based Convex Sets for Blind Deconvolution of Microscopic Images
Tofighi M., Yorulmaz O., Koese K., Yildirim D. C., Cetin-Atalay R., ÇETİN A. E.
IEEE JOURNAL OF SELECTED TOPICS IN SIGNAL PROCESSING , cilt.10, sa.1, ss.81-91, 2016 (SCI-Expanded)
2015
2015Ynamide Click chemistry in development of triazole VEGFR2 TK modulators.
Vojtickova M., Dobias J., Hanquet G., Addova G., Cetin-Atalay R., Yildirim D. C., et al.
European journal of medicinal chemistry , cilt.103, ss.105-22, 2015 (SCI-Expanded)
2015
2015Application of the Ugi reaction with multiple amino acid-derived components: synthesis and conformational evaluation of piperazine-based minimalist peptidomimetics.
Stucchi M., Cairati S., Cetin-Atalay R., Christodoulou M. S., Grazioso G., Pescitelli G., et al.
Organic & biomolecular chemistry , cilt.13, sa.17, ss.4993-5005, 2015 (SCI-Expanded)
2014
2014Near-IR absorbing BODIPY derivatives as glutathione-activated photosensitizers for selective photodynamic action.
Turan I., Cakmak F., Yildirim D. C., Cetin-Atalay R., Akkaya E.
Chemistry (Weinheim an der Bergstrasse, Germany) , cilt.20, ss.16088-92, 2014 (SCI-Expanded)
Diğer Dergilerde Yayınlanan Makaleler
2021
2021Data Centric Molecular Analysis and Evaluation of Hepatocellular Carcinoma Therapeutics Using Machine Intelligence-Based Tools
Cetin-Atalay R., Kahraman D. C., Nalbat E., Rifaioğlu A. S., Atakan A., Dönmez A., et al.
JOURNAL OF GASTROINTESTINAL CANCER , cilt.52, sa.4, ss.1266-1276, 2021 (ESCI)
Hakemli Kongre / Sempozyum Bildiri Kitaplarında Yer Alan Yayınlar
2023
2023Repurposing Drugs to Target Molecular Networks in Hepatocellular Carcinoma Cells & Stem Cells for Innovative Treatment Strategies
NALBAT E., TUNÇBAĞ N., KAHRAMAN D. C., ATALAY R.
4th Open Research Day, Türkiye, 01 Aralık 2023
2023
2023Network-based drug repurposing approach identifies novel drugs and drug combinations against HCC
NALBAT E., TUNÇBAĞ N., KAHRAMAN D. C., ATALAY R.
AASLD-TASL Digital Hepatology Meeting, Ankara, Türkiye, 28 - 29 Nisan 2023
2019
2019A NEW THIADIAZINE DERIVATIVE INDUCES OXIDATIVE STRESS DEPENDENT CELL DEATH IN HEPATOCELLULAR CARCINOMA STEM CELLS
KAHRAMAN D. C., GÜVEN E. B., Aytac P., TOZKOPARAN KÖPRÜCÜ B., ATALAY R.
Annual Meeting of the American-Association-for-the-Study-of-Liver-Diseases (AASLD) / Liver Meeting, Massachusetts, Amerika Birleşik Devletleri, 8 - 12 Kasım 2019, cilt.70
2019
2019In silico modeling and in vitro validation of undefined off-target of drugs in hepatocellular carcinoma
Sinoplu E., Tuncbag N., Kahraman D. C., Atalay R. C.
Annual Meeting of the American-Association-for-Cancer-Research (AACR), Georgia, Amerika Birleşik Devletleri, 29 Mart - 03 Nisan 2019, cilt.79
2019
2019A new thiadiazine derivative induces oxidative stress dependent JNK pathway activation and cell death in hepatocellular carcinoma
KAHRAMAN D. C., GÜVEN E. B., TOZKOPARAN KÖPRÜCÜ B., ATALAY R.
Annual Meeting of the American-Association-for-Cancer-Research (AACR), Georgia, Amerika Birleşik Devletleri, 29 Mart - 03 Nisan 2019, cilt.79
2018
2018Differential alteration of IL-8 in liver cancer stem cell enrichment in response to PI3K/Akt/mTOR inhibitors and sorafenib
Kahraman D. C., Kahraman T., ATALAY R.
American Association for Cancer Research Annual Meeting 2018, Chicago, Amerika Birleşik Devletleri, 12 - 18 Nisan 2018, cilt.78, ss.3937
2017
2017Abstract LB-A08: Differential alteration of IL-8 in response to Sorafenib and PI3K/Akt/mTOR inhibitors in liver cancer cells and in liver cancer stem cells
Kahraman D. C., ATALAY R.
AACR-NCI-EORTC International Conference, Philadelphia, 26 - 30 Ekim 2017
2017
2017HEPATOCELLULAR CARCİNOMA TERAPEUTICS: SYNTHESIS AND BIOLOGICAL EVALUATION INDOLE-3-CARBOXAMIDES
Kılıç E. K., Kahraman D. C., ATALAY R., BAYTAŞ S.
2nd International Gazi Pharma Symposium, 11 - 13 Ekim 2017
2017
2017ANTICANCER EFFECTS OF NEW INDOLE –PYRAZOLE AND ONDOLE-OSOXAZOLE HYBRIDS DESIGN, SYNTHESIS AND EVALUATION OF ACTIVITY
Hawash M. M., Kahraman D. C., ATALAY R., BAYTAŞ S.
2nd International Gazi Pharma Symposium, 11 - 13 Ekim 2017
2017
2017Induction of Apoptosis in Hepatocellular Carcinoma Cell Lines by Novel Indolylacrylamide Derivatives: Synthesis and Biological Evaluation
Hawash M., Kahraman D. C., ATALAY R., BAYTAŞ S.
26th ISHC Congress on Heterocyclic Chemistry, 3 - 08 Eylül 2017
2016
2016Dielectrophoretic Spectra of CD133+/EpCAM+ HUH7 Cancer Stem Cells and HUH7 Cancer Cells
Çağlayan Z., Demircan Yalçın Y., Özkayar G., Kahraman D. C., Atalay R., Özgür E., et al.
Dielectrophoresis 2016, Massachusetts, Amerika Birleşik Devletleri, 13 - 15 Temmuz 2016, ss.1-4
2016
2016Sequential treatment of HCC cells with PI3K Akt mTOR pathway inhibitors prior to sorafenib attenuates cancer stem cell population
Kahraman D. C., Kahraman T., ATALAY R.
EACR 27, 1 - 04 Temmuz 2016, cilt.61, ss.77
Desteklenen Projeler
2023 - 2026
2023 - 2026Hepatosellüler Karsinomada Hippo Sinyal Yolağı Hedefli Bileşiklerin Mekanizmasının Aydınlatılması
TÜBİTAK Projesi
Kahraman D. C., Güntekin Ergün S.(Yürütücü)
2022 - 2025
2022 - 2025Öncü Bileşik Optimizasyonu ile Tasarlanan Antikanser Etkili Olabilecek Yeni Bileşiklerin Sentezi, Yapı-Etki İlişkileri ve Moleküler Etki Mekanizmalarının İncelenmesi
TÜBİTAK Projesi
Kahraman D. C., Baytaş S.(Yürütücü)
2020 - 2023
2020 - 2023Hepatosellüler Kansere Özgü Ctdna Tayini Için Düşük Enerji Ile Uyarılabilen Ve Çoklu Analize Olanak Sağlayan Mikroakışkan Tabanlı Ve Üst-Çevirici Nanopartikül-Kuantum Nokta Hibrid Yapılı Fotoelektrokimyasal Sensörün Geliştirilmesi
TÜBİTAK Projesi
Kahraman D. C., Külah H. (Yürütücü)
2020 - 2022
2020 - 2022Derin Öğrenme Bazlı Farmakogenomik Modelleme ile Geniş Çaplı Kanser Hücre Hattı İlaç Yanıt Tahmini
Türkiye Sağlık Enstitüleri Başkanlığı (TÜSEB) Araştırma Projesi
Kahraman D. C., Doğan T.(Yürütücü)
Bilimsel Kuruluşlardaki Üyelikler / Görevler
2019 - Devam Ediyor
2019 - Devam EdiyorAmerican Association for the Study of Liver Diseases (AASLD)
Üye
2019 - Devam Ediyor
2019 - Devam EdiyorTürk Karaciğer Araştırmaları Derneği
Üye
2017 - Devam Ediyor
2017 - Devam EdiyorAmerican Association for Cancer Research (AACR)
Üye
2016 - Devam Ediyor
2016 - Devam EdiyorMoleküler Kanser Araştırma Derneği (MOKAD)
Üye
2016 - Devam Ediyor
2016 - Devam EdiyorEuropean Association for Cancer Research (EACR)
Üye
Ödüller
Eylül 2023
Eylül 2023Young Basic Cancer Researcher Award
Moleküler Kanser Araştırmaları Derneği (Mokad)
Ağustos 2019
Ağustos 2019International Early Career Investigator Award
American Association For The Study Of Liver Diseases
Mayıs 2019
Mayıs 2019Special Mention Poster Award
Enformatik Enstitüsü, Metu
Ekim 2017
Ekim 2017