Education Information
2011 - 2018
2011 - 2018Doctorate
Ihsan Dogramaci Bilkent University, Faculty Of Scıence, Department Of Molecular Bıology And Genetıcs, Turkey
2007 - 2011
2007 - 2011Undergraduate
Ihsan Dogramaci Bilkent University, Faculty Of Scıence, Department Of Molecular Bıology And Genetıcs, Turkey
Foreign Languages
C1 Advanced
C1 AdvancedEnglish
Research Areas
Molecular Biology and Genetics
Moleculer Biology of Cancer
Academic Titles / Tasks
2020 - Continues
2020 - ContinuesLecturer PhD
Middle East Technical University, Graduate School of Informatics, Medical Informatics
Advising Theses
2023
2023Postgraduate
MECHANISMS OF SYNERGISTIC ANTITUMOR EFFECT OF NAPROXEN AND SORAFENIB IN HEPATOCELLULAR CARCINOMA
Kahraman D. C. (Co-Advisor), Muyan M.
E.AKAR(Student)
2022
2022Postgraduate
IN VITRO AUTOCRINE SECRETION OF INFLAMMATORY CYTOKINES IN RESPONSE TO DRUG STRESS IN HCC AND LCSC POPULATIONS
Kahraman D. C. (Co-Advisor), Muyan M.
N.ECE(Student)
2021
2021Postgraduate
BIOACTIVITY ANALYSIS OF NOVEL INDOLE DERIVATIVES ON HEPATOCELLULAR CARCINOMA AS SIRTUIN INHIBITORS
Kahraman D. C. (Co-Advisor), Muyan M.
B.BINARCI(Student)
Published journal articles indexed by SCI, SSCI, and AHCI
2023
2023Design, synthesis, molecular docking studies and biological evaluation of thiazole carboxamide derivatives as COX inhibitors
Hawash M., Jaradat N., Abualhasan M., ŞÜKÜROĞLU M. K., Qaoud M. T., KAHRAMAN D. C., et al.
BMC Chemistry
, vol.17, no.1, 2023 (SCI-Expanded)
2023
2023Novel indole-pyrazole hybrids as potential tubulin-targeting agents; Synthesis, antiproliferative evaluation, and molecular modeling studies
Hawash M., Ergun S. G., KAHRAMAN D. C., OLĞAÇ A., Hamel E., Cetin-Atalay R., et al.
Journal of Molecular Structure
, vol.1285, 2023 (SCI-Expanded)
2022
2022A new triazolothiadiazine derivative inhibits stemness and induces cell death in HCC by oxidative stress dependent JNK pathway activation
KAHRAMAN D. C., Guven E. B., Aytac P. S., Aykut G., Tozkoparan B., Atalay R. C.
SCIENTIFIC REPORTS
, vol.12, no.1, 2022 (SCI-Expanded)
2022
2022Design and synthesis of novel substituted indole-acrylamide derivatives and evaluation of their anti-cancer activity as potential tubulin-targeting agents
Hawash M., KAHRAMAN D. C., OLĞAÇ A., Ergun S. G., Hamel E., Cetin-Atalay R., et al.
JOURNAL OF MOLECULAR STRUCTURE
, vol.1254, 2022 (SCI-Expanded)
2022
2022Low Density Granulocytes and Dysregulated Neutrophils Driving Autoinflammatory Manifestations in NEMO Deficiency
Yilmaz N. S., Eltan S. B., KAYAOĞLU B., Geckin B., Heredia R. J., Sefer A. P., et al.
JOURNAL OF CLINICAL IMMUNOLOGY
, vol.42, no.3, pp.582-596, 2022 (SCI-Expanded)
2022
2022Context dependent isoform specific PI3K inhibition confers drug resistance in hepatocellular carcinoma cells.
Narci K., Kahraman D. C., Koyas A., Ersahin T., Tuncbag N., Atalay R. C.
BMC cancer
, vol.22, no.1, pp.320, 2022 (SCI-Expanded)
2021
2021Synthesis of novel indole-isoxazole hybrids and evaluation of their cytotoxic activities on hepatocellular carcinoma cell lines
Hawash M., KAHRAMAN D. C., Ergun S. G., Cetin-Atalay R., BAYTAŞ S.
BMC CHEMISTRY
, vol.15, no.1, 2021 (SCI-Expanded)
2021
2021Synthesis and biological evaluation of novel isoxazole-piperazine hybrids as potential anti-cancer agents with inhibitory effect on liver cancer stem cells
Ibis K., NALBAT E., ÇALIŞKAN B., KAHRAMAN D. C., Cetin-Atalay R., BANOĞLU E.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
, vol.221, 2021 (SCI-Expanded)
2021
2021Induction of Apoptosis in Hepatocellular Carcinoma Cell Lines by Novel Indolylacrylamide Derivatives: Synthesis and Biological Evaluation
Hawash M., Kahraman D. C., Cetin-Atalay R., BAYTAŞ S.
CHEMISTRY & BIODIVERSITY
, vol.18, no.5, 2021 (SCI-Expanded)
2021
2021MDeePred: Novel multi-channel protein featurization for deep learning-based binding affinity prediction in drug discovery
Rifaioglu A., Atalay R. C., KAHRAMAN D. C., DOĞAN T., Martin M., ATALAY M. V.
Bioinformatics
, vol.37, no.5, pp.693-704, 2021 (SCI-Expanded)
2021
2021Transcriptome profiles associated with selenium-deficiency-dependent oxidative stress identify potential diagnostic and therapeutic targets in liver cancer cells
Gozen D., KAHRAMAN D. C., Narci K., Shehwana H., KONU KARAKAYALI Ö., Cetin-Atalay R.
TURKISH JOURNAL OF BIOLOGY
, vol.45, no.2, pp.149-164, 2021 (SCI-Expanded)
2020
2020CXXC5 as an unmethylated CpG dinucleotide binding protein contributes to estrogen-mediated cellular proliferation.
Ayaz G., Razizadeh N., Yaşar P., Kars G., Kahraman D. C., Saatci Ö., et al.
Scientific reports
, vol.10, pp.5971, 2020 (SCI-Expanded)
2019
2019Targeting PI3K/Akt/mTOR Pathway Identifies Differential Expression and Functional Role of IL8 in Liver Cancer Stem Cell Enrichment
KAHRAMAN D. C., Kahraman T., Cetin-Atalay R.
MOLECULAR CANCER THERAPEUTICS
, vol.18, no.11, pp.2146-2157, 2019 (SCI-Expanded)
2019
2019Synthesis, anticancer activity, toxicity evaluation and molecular docking studies of novel phenylaminopyrimidine-(thio)urea hybrids as potential kinase inhibitors.
Ture A., Kahraman D. C., Cetin-Atalay R., Helvacioglu S., Charehsaz M., KÜÇÜKGÜZEL İ.
Computational biology and chemistry
, vol.78, pp.227-241, 2019 (SCI-Expanded)
2018
2018Design, synthesis and biological evaluation of novel 1,3-diarylpyrazoles as cyclooxygenase inhibitors, antiplatelet and anticancer agents.
Inceler N., ÖZKAN Y., Turan N. N., Kahraman D. C., Cetin-Atalay R., BAYTAŞ S.
MedChemComm
, vol.9, no.5, pp.795-811, 2018 (SCI-Expanded)
2017
2017Synthesis and biological evaluation of novel pyrazolic chalcone derivatives as novel hepatocellular carcinoma therapeutics.
Hawash M. M. A., Kahraman D. C., Eren F., Atalay R. C., BAYTAŞ S.
European journal of medicinal chemistry
, vol.129, pp.12-26, 2017 (SCI-Expanded)
2016
2016Quinoides and VEGFR2 TKIs influence the fate of hepatocellular carcinoma and its cancer stem cells.
Kahraman D. C., Hanquet G., Jeanmart L., Lanners S., Sramel P., Bohac A., et al.
MedChemComm
, vol.8, no.1, pp.81-87, 2016 (SCI-Expanded)
2016
2016Phase and TV Based Convex Sets for Blind Deconvolution of Microscopic Images
Tofighi M., Yorulmaz O., Koese K., Yildirim D. C., Cetin-Atalay R., ÇETİN A. E.
IEEE JOURNAL OF SELECTED TOPICS IN SIGNAL PROCESSING
, vol.10, no.1, pp.81-91, 2016 (SCI-Expanded)
2015
2015Ynamide Click chemistry in development of triazole VEGFR2 TK modulators.
Vojtickova M., Dobias J., Hanquet G., Addova G., Cetin-Atalay R., Yildirim D. C., et al.
European journal of medicinal chemistry
, vol.103, pp.105-22, 2015 (SCI-Expanded)
2015
2015Application of the Ugi reaction with multiple amino acid-derived components: synthesis and conformational evaluation of piperazine-based minimalist peptidomimetics.
Stucchi M., Cairati S., Cetin-Atalay R., Christodoulou M. S., Grazioso G., Pescitelli G., et al.
Organic & biomolecular chemistry
, vol.13, no.17, pp.4993-5005, 2015 (SCI-Expanded)
2014
2014Near-IR absorbing BODIPY derivatives as glutathione-activated photosensitizers for selective photodynamic action.
Turan I., Cakmak F., Yildirim D. C., Cetin-Atalay R., Akkaya E.
Chemistry (Weinheim an der Bergstrasse, Germany)
, vol.20, pp.16088-92, 2014 (SCI-Expanded)
Articles Published in Other Journals
2021
2021Data Centric Molecular Analysis and Evaluation of Hepatocellular Carcinoma Therapeutics Using Machine Intelligence-Based Tools
Cetin-Atalay R., Kahraman D. C., Nalbat E., Rifaioğlu A. S., Atakan A., Dönmez A., et al.
JOURNAL OF GASTROINTESTINAL CANCER
, vol.52, no.4, pp.1266-1276, 2021 (ESCI)
Refereed Congress / Symposium Publications in Proceedings
2023
2023Repurposing Drugs to Target Molecular Networks in Hepatocellular Carcinoma Cells & Stem Cells for Innovative Treatment Strategies
NALBAT E., TUNÇBAĞ N., KAHRAMAN D. C., ATALAY R.
4th Open Research Day, Turkey, 01 December 2023
2023
2023Network-based drug repurposing approach identifies novel drugs and drug combinations against HCC
NALBAT E., TUNÇBAĞ N., KAHRAMAN D. C., ATALAY R.
AASLD-TASL Digital Hepatology Meeting, Ankara, Turkey, 28 - 29 April 2023
2019
2019A NEW THIADIAZINE DERIVATIVE INDUCES OXIDATIVE STRESS DEPENDENT CELL DEATH IN HEPATOCELLULAR CARCINOMA STEM CELLS
KAHRAMAN D. C., GÜVEN E. B., Aytac P., TOZKOPARAN KÖPRÜCÜ B., ATALAY R.
Annual Meeting of the American-Association-for-the-Study-of-Liver-Diseases (AASLD) / Liver Meeting, Massachusetts, United States Of America, 8 - 12 November 2019, vol.70
2019
2019In silico modeling and in vitro validation of undefined off-target of drugs in hepatocellular carcinoma
Sinoplu E., Tuncbag N., Kahraman D. C., Atalay R. C.
Annual Meeting of the American-Association-for-Cancer-Research (AACR), Georgia, United States Of America, 29 March - 03 April 2019, vol.79
2019
2019A new thiadiazine derivative induces oxidative stress dependent JNK pathway activation and cell death in hepatocellular carcinoma
KAHRAMAN D. C., GÜVEN E. B., TOZKOPARAN KÖPRÜCÜ B., ATALAY R.
Annual Meeting of the American-Association-for-Cancer-Research (AACR), Georgia, United States Of America, 29 March - 03 April 2019, vol.79
2018
2018Differential alteration of IL-8 in liver cancer stem cell enrichment in response to PI3K/Akt/mTOR inhibitors and sorafenib
Kahraman D. C., Kahraman T., ATALAY R.
American Association for Cancer Research Annual Meeting 2018, Chicago, United States Of America, 12 - 18 April 2018, vol.78, pp.3937
2017
2017Abstract LB-A08: Differential alteration of IL-8 in response to Sorafenib and PI3K/Akt/mTOR inhibitors in liver cancer cells and in liver cancer stem cells
Kahraman D. C., ATALAY R.
AACR-NCI-EORTC International Conference, Philadelphia, 26 - 30 October 2017
2017
2017HEPATOCELLULAR CARCİNOMA TERAPEUTICS: SYNTHESIS AND BIOLOGICAL EVALUATION INDOLE-3-CARBOXAMIDES
Kılıç E. K., Kahraman D. C., ATALAY R., BAYTAŞ S.
2nd International Gazi Pharma Symposium, 11 - 13 October 2017
2017
2017ANTICANCER EFFECTS OF NEW INDOLE –PYRAZOLE AND ONDOLE-OSOXAZOLE HYBRIDS DESIGN, SYNTHESIS AND EVALUATION OF ACTIVITY
Hawash M. M., Kahraman D. C., ATALAY R., BAYTAŞ S.
2nd International Gazi Pharma Symposium, 11 - 13 October 2017
2017
2017Induction of Apoptosis in Hepatocellular Carcinoma Cell Lines by Novel Indolylacrylamide Derivatives: Synthesis and Biological Evaluation
Hawash M., Kahraman D. C., ATALAY R., BAYTAŞ S.
26th ISHC Congress on Heterocyclic Chemistry, 3 - 08 September 2017
2016
2016Dielectrophoretic Spectra of CD133+/EpCAM+ HUH7 Cancer Stem Cells and HUH7 Cancer Cells
Çağlayan Z., Demircan Yalçın Y., Özkayar G., Kahraman D. C., Atalay R., Özgür E., et al.
Dielectrophoresis 2016, Massachusetts, United States Of America, 13 - 15 July 2016, pp.1-4
2016
2016Sequential treatment of HCC cells with PI3K Akt mTOR pathway inhibitors prior to sorafenib attenuates cancer stem cell population
Kahraman D. C., Kahraman T., ATALAY R.
EACR 27, 1 - 04 July 2016, vol.61, pp.77
Supported Projects
2023 - 2026
2023 - 2026Hepatosellüler Karsinomada Hippo Sinyal Yolağı Hedefli Bileşiklerin Mekanizmasının Aydınlatılması
TUBITAK Project
Kahraman D. C., Güntekin Ergün S.(Executive)
2022 - 2025
2022 - 2025Öncü Bileşik Optimizasyonu ile Tasarlanan Antikanser Etkili Olabilecek Yeni Bileşiklerin Sentezi, Yapı-Etki İlişkileri ve Moleküler Etki Mekanizmalarının İncelenmesi
TUBITAK Project
Kahraman D. C., Baytaş S.(Executive)
2021 - 2024
2021 - 2024Az Biyoaktif Bileşik Verisi Olan Proteinlere Karşı Sanal Tarama için Derin Öğrenme Modelleri (Azderin)
TUBITAK Project
ATALAY M. V. (Executive), KAHRAMAN D. C., DOĞAN T., ACAR A. C., ATALAY R.
2020 - 2023
2020 - 2023
Hepatosellüler Kansere Özgü Ctdna Tayini Için Düşük Enerji Ile Uyarılabilen Ve Çoklu Analize Olanak Sağlayan Mikroakışkan Tabanlı Ve Üst-Çevirici Nanopartikül-Kuantum Nokta Hibrid Yapılı Fotoelektrokimyasal Sensörün Geliştirilmesi
TUBITAK Project
Kahraman D. C., Külah H. (Executive)
2019 - 2023
2019 - 2023
İlaçların Daha Önce Tanımlanmamış Hedef Dışı Etkilerinin Hesaplamalı System Biyolojisi Yöntemleri ile Modellenmesi ve Hepatoselüler Kanserde Doğrulanması
TUBITAK Project
ATALAY R., KAHRAMAN D. C. (Executive)
2020 - 2022
2020 - 2022
Derin Öğrenme Bazlı Farmakogenomik Modelleme ile Geniş Çaplı Kanser Hücre Hattı İlaç Yanıt Tahmini
Research Project of the Presidency of Turkey Health Institutes (TÜSEB)
Kahraman D. C., Doğan T.(Executive)
Activities in Scientific Journals
2024 - Continues
2024 - ContinuesTURKISH JOURNAL OF GASTROENTEROLOGY
Assistant Editor/Section Editor
Memberships / Tasks in Scientific Organizations
2019 - Continues
2019 - ContinuesAmerican Association for the Study of Liver Diseases (AASLD)
Member
2019 - Continues
2019 - ContinuesTürk Karaciğer Araştırmaları Derneği
Member
2017 - Continues
2017 - ContinuesAmerican Association for Cancer Research (AACR)
Member
2016 - Continues
2016 - ContinuesMoleküler Kanser Araştırma Derneği (MOKAD)
Member
2016 - Continues
2016 - ContinuesEuropean Association for Cancer Research (EACR)
Member
Awards
September 2023
September 2023Young Basic Cancer Researcher Award
Moleküler Kanser Araştırmaları Derneği (Mokad)
August 2019
August 2019International Early Career Investigator Award
American Association For The Study Of Liver Diseases
May 2019
May 2019Special Mention Poster Award
Enformatik Enstitüsü, Metu
October 2017
October 2017