Akademik Veri Yönetim Sistemi
Tezin Türü: Yüksek Lisans
Tezin Yürütüldüğü Kurum: Orta Doğu Teknik Üniversitesi, Fen Edebiyat Fakültesi, Kimya Bölümü, Türkiye
Tezin Onay Tarihi: 2005
Tezin Dili: İngilizce
Öğrenci: Murat Işık
Danışman: CİHANGİR TANYELİ
Özet:Chiral aromatic nitrogen heterocycles are finding many applications in asymmetric organic synthesis, particularly as ligands in the preparation of chiral metal complexes. Since camphor-based chiral auxiliaries are known to be especially effective, a number of pyridines fused to the camphor skeleton have been reported. It is well known that nicotinic acid and its derivatives exhibiting qualitatively the biological activity of nicotinamide, which acts as an electron acceptor in many biological redox reactions. In connection to our works, we attempted to develop short and convenient way to prepare various camphorderived chiral pyridine or nicotinic acid derivatives. Here we report our results obtained from the annulation of (+)- b- hydroxymethylenecamphor as the feasible chiral pool with various enamines derived from active methylene compounds. (+)- b- Hydroxymethylenecamphor prepared from cheap and easily available natural (+)-camphor and enamines were transformed into chiral camphor-based pyridine derivatives via tandem condensation reaction in good yields.