Investigation of the effects of different macrostructures on conjugated polymer based amperometric biosensor performance

---

Tezin Türü: Yüksek Lisans

Tezin Yürütüldüğü Kurum: Orta Doğu Teknik Üniversitesi, Fen Edebiyat Fakültesi, Kimya Bölümü, Türkiye

Tezin Onay Tarihi: 2018

Öğrenci: ECE BÜBER

Danışman: LEVENT KAMİL TOPPARE

Özet:

In this thesis, the use of different macrostructures in the surface design of conjugated polymer based amperometric biosensors was investigated since surface properties play a crucial role in the performance of biosensors. Conjugated polymers (CPs) provide biosensors superior features since they exhibit conductivity, high mechanical strength and processability. Moreover, phthalocyanines (Pcs) are promising molecules for biosensor applications due to their electronic properties, rich redox chemistry and high electrochemical stability. In addition to phthalocyanines, dendrimers are suitable host molecules for accommodation of guest molecules due to their three-dimensional structure having an internal void space. Especially, poly(amidoamine) (PAMAM), can be used in biosensor applications since it contains a number of terminal amino groups which enhances the attachment of biomolecules. Multi-walled carbon nanotubes (MWCNTs) have also extensively used in biosensor applications since they are compatible with biomolecules in addition to their mechanical strength, stability and conductivity properties. By taking the advantages of these materials, two novel glucose biosensors; CPs/MWCNTs/ZnPc and CPs/MWCNTs/PAMAM were fabricated. Their operational and kinetic parameters and surface features were characterized and the biosensors were successfully tested for real time analyses.