Akademik Veri Yönetim Sistemi
Tezin Türü: Yüksek Lisans
Tezin Yürütüldüğü Kurum: Orta Doğu Teknik Üniversitesi, Fen Edebiyat Fakültesi, Kimya Bölümü, Türkiye
Tezin Onay Tarihi: 2016
Tezin Dili: İngilizce
Öğrenci: Zeynep Seda Eren
Danışman: AYŞEN YILMAZ
Özet:Mesoporous silica particles have been used to enhance the loading capacity of drugs into the support, increase the solubility of drug and control drug release. In this study, poorly water-soluble, nonsteroidal anti-inflammatory drug with relatively low bioavailability Celecoxib, was used as a model drug in order to determine the drug loading and release properties of silica particles. In order to synthesize SBA15 particles, hydrothermal synthesis method was used, SBA-15 samples were functionalized by post-grafting method with (3-Aminopropyl) triethoxysilane, APTES (SBA-15-A). Moreover, Boron doped SBA-15 (SBA-15-B) samples were prepared and borosilicate samples were obtained. After APTES functionalization and Boron doping process, drug was loaded to the particles in three different solvents; ethanol, methanol and hexane to observe the effect on drug loading and release properties. Particle morphology and solvent effect on drug loading capacity of the silica particles were investigated and the effect of pH on drug release was studied. For this purpose, vi SBA-15 particles were characterized by using x-ray diffraction (XRD), small – angle x-ray spectrometry (SAXS), N2 adsorption - desorption, Fourier transform infra-red spectroscopy (FT-IR), differential scanning calorimetry (DSC), scanning electron microscope (SEM), transmission electron microscope (TEM), ultraviolet-visible spectrometry (UV-vis) and thermogravimetric analysis (TGA). Then, highly improved release rate of Celecoxib by using SBA-15 silica particles as drug carriers compared with the commercial drug, Celebrex. For the release experiments of the Celecoxib particles in all silica samples, phosphate buffer solution (PBS) was used in pH=7.4 and pH=5 at 37 ˚C. According to release results, slow release for SBA-15-A (APTES functionalized SBA-15) particles was observed, while there was burst release for SBA-15-B (Boron doped SBA-15) particles and all silica samples prepared by hexane solvent. All of the results demonstrated here confirm the potential use of silica supports as potential drug delivery carriers for poorly water soluble drugs.