Akademik Veri Yönetim Sistemi
Tezin Türü: Yüksek Lisans
Tezin Yürütüldüğü Kurum: Orta Doğu Teknik Üniversitesi, Türkiye
Tezin Onay Tarihi: 2015
Tezin Dili: İngilizce
Öğrenci: Büşra Günay
Eş Danışman: NESRİN HASIRCI, VASIF NEJAT HASIRCI
Özet:This thesis aims to develop a polymeric composite material that can be used as a lumbar fusion cage material. Lumbar fusion cages are one of the devices used in spinal fusion procedures for some spinal disorders such as spondylosis and degenerative disc disease that may occur due to age, trauma or genetic reasons. These devices are most frequently made of metals (e.g. titanium) and polymers (e.g. PEEK). The mechanical properties of such a device should not be much higher than that of the bone so that stress shielding does not lead to defective healing. It should have proper interaction with the cells to achieve high fusion rates. In order to develop a material for such a device, poly(methylmethacrylate) (PMMA) and hydroxyapatite (HAp) are compounded together in varying ratios and molded into plates using hot melt extrusion and injection molding. The plates were tested to assess the mechanical properties and in vitro to determine the changes in cell morphology and rate of proliferation of human osteoblast-like (HOB) cells. It was found that the mechanical properties of PMMA were significantly improved with increasing amount of HAp. HOB cells responded to the increasing HAp content and roughness of the surfaces with increased proliferation and presented filopodia indicating good interaction with the plate surface. The optimum HAp content for use as a fusion cage is around 20-30% (w/w). It was concluded that PMMA can be compounded with HAp successfully to yield a good material for use in spinal fusion studies.