Core/shell type, Ce3+ and Tb3+ doped GdBO3/SiO2 system: Synthesis and celecoxib drug delivery applications

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Tezin Türü: Yüksek Lisans

Tezin Yürütüldüğü Kurum: Orta Doğu Teknik Üniversitesi, Fen Bilimleri Enstitüsü, Fen Bilimleri Enstitüsü, Türkiye

Tezin Onay Tarihi: 2019

Tezin Dili: İngilizce

Öğrenci: PELİN AKMAN

Danışman: Ayşen Yılmaz

Özet:

Multifunctional nanoparticles have been widely used as drug carriers to control drug release. However, besides controlling drug release, it is important to track the behavior of the drug in body. For this purpose, functionalizing the drug carriers with luminescent or magnetic materials and using them as bioimaging agents have attracted attention in recent years. In this study, luminescent and magnetic core/shell Gd1-xyCexTbyBO3@SiO2 (x=0.05, y=0.05) nanoparticles were synthesized and used in celecoxib drug delivery system. Celecoxib is a nonsteroidal anti-inflammatory and poorly water soluble, hydrophobic drug. In order to visualize the drug in body, both magnetic and luminescent core was synthesized. This core is composed of Ce and Tb doped Gadolinium borate, Gd1-x-yCexTbyBO3 and it was synthesized by Pechini solgel method. Different proportions of Gd1-x-yCexTby BO3 were synthesized and their photoluminescence (PL) spectra were compared. After that, Gd0.90Ce0.05Tb0.05BO3 was determined as the best luminescent core. Also, Gadolinium is strongly paramagnetic and widely used as magnetic resonance imaging (MRI) contrast agent. To increase drug loading capacity, mesoporous silica was chosen because of its high surface area, porosity, high biocompatibility and easy synthesis route. Mesoporous silica coating to