Akademik Veri Yönetim Sistemi
Tezin Türü: Yüksek Lisans
Tezin Yürütüldüğü Kurum: Orta Doğu Teknik Üniversitesi, Türkiye
Tezin Onay Tarihi: 2014
Tezin Dili: İngilizce
Öğrenci: Hikmet Taner Teker
Eş Danışman: VİLDA PURUTÇUOĞLU GAZİ, TÜLİN YANIK
Özet:Obesity is a medical condition that carries increased risk for the onset of metabolic disorders and many other chronic diseases. However, etiology of obesity and how obsegenic traits are emerged remain to be elucidated. Investigations about this issue focused on one of the brain regions, hypothalamus,where energy homeostasis,food intake and appetite are regulated. Under the condition of hypothalamic inflammation and/or because of the passage of toxic substances from the circulating blood to the hypothalamus, hypothalamic cells are disrupted and metabolic deregulations might initiate, risk factors for obesity and other cluster of metabolic disordersmight increase. Recent studies have shown that the maternal obesity and/or obesogenic diet consumption during pregnancy may initiate hypothalamic inflammation which may permanently alter hypothalamic structures and functions in the offspring. Based on evidences that neuro-vascular changes, especially changes in brain blood barrier (BBB) integrity arenot only results in passage of toxic substances from circulating bloods but also may initiate or contribute to hypothalamic inflammation and affect microvessel density. In this study, we investigated changes in BBB integrity of 20 days-old Wistar rat offspring whose mothers were fed with HFD. Our results shows thatoffspringwhose mothers fed with HFD (cafeteria diet) hypothalamicBBB integritywas increased significantly compare to controls.Our results suggest that maternal obesity has impacts on hypothalamicBBB integrity and such changes can inhibit certain crutial signals to reach hypothalamus and initiate cascade of disease conditions as blocking signal homeostasisduring development.