Akademik Veri Yönetim Sistemi
Tezin Türü: Yüksek Lisans
Tezin Yürütüldüğü Kurum: Orta Doğu Teknik Üniversitesi, Fen Edebiyat Fakültesi, Kimya Bölümü, Türkiye
Tezin Onay Tarihi: 2013
Öğrenci: GAMZE GEZER
Danışman: AYŞEN YILMAZ
Özet:Mesoporous silica particles have been used to enhance the loading capacity of drugs into these particles, increase bioavailability and control drug release. In this study SBA-15 particles were synthesized and functionalized to improve the loading capacity and release rate of drug. Then, drug loading and release process were investigated. Celecoxib was chosen as a model drug which is very hydrophobic. SBA-15 particles were used due to their highly ordered, well-defined mesoporous structure. These particles were modified by post-grafting method. In order to synthesize SBA-15 particles, hydrothermal synthesis method was used, Pluronic 123 triblock copolymer was used as starting material and tetraethyl orthosilicate was added as a silica source. SBA-15 samples were functionalized by post-grafting method with (3-Aminopropyl) triethoxysilane (APTES). Moreover, Boron doping of SBA-15 samples was prepared and so borosilicate samples were obtained. After functionalization process, drug loading of samples were performed with different concentration of drug in silica and to control drug release rate, release experiments results were compared. For the characterization process of pure and drug loaded samples, X-ray Diffraction (XRD), Small-Angle X-ray Spectrometry (SAXS), N2 adsorption-desorption, Fourier Transform Infra-red (FTIR), Elemental Analysis, Scanning Electron Microscope (SEM), Transmission Electron Microscope (TEM), Ultra-Violet Spectrometry (UV-VIS), Zeta Potential and High-Performance Liquid Chromatography (HPLC) methods were applied. According to characterization process, amine functionalized SBA-15 samples and borosilicate samples showed the best results in loading and release experiments. For loading process amine functionalized SBA-15 particles had 61.72 % efficiency and borosilicate samples had 76.33 % efficiency. Besides, Borosilicate and amine functionalized SBA-15 samples had highest release rate of Celecoxib which were 37.57 % and 41.61 % respectively. Functionalization process was successful to improve drug loading capacity and release rate.