Effect of film deposition conditions on the properties of multilayers of poly[2-(dimethylamino)ethyl methacrylate-b-poly(2-(diethylamino)ethyl methacrylate)] micelles and poly(sodium 4-styrenesulfonate)

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Tezin Türü: Yüksek Lisans

Tezin Yürütüldüğü Kurum: Orta Doğu Teknik Üniversitesi, Fen Edebiyat Fakültesi, Kimya Bölümü, Türkiye

Tezin Onay Tarihi: 2017

Öğrenci: DİLARA GÜNDOĞDU

Danışman: İREM EREL GÖKTEPE

Özet:

Block copolymer micelles (BCMs) are ideal drug carriers due to their hydrophobic core regions which can encapsulate water insoluble drug molecules. BCMs with stimuli-responsive cores are of specific interest due to release of the cargo by simply changing the environmental conditions, e.g. pH, temperature, ionic strength. Incorporation of BCMs into layer-by-layer (LbL) films is important to keep the BCMs stable in bloodstream and prevent the release of the cargo at an early stage. In addition, BCMs increase the loading capacity of the LbL films for functional hydrophobic molecules. In this study poly[2-(dimethylamino)ethyl methacrylate-b-poly(2-(diethylamino)ethyl methacrylate)] (PDMA-b-PDEA) micelles with pH/temperature responsive PDMA-coronae and pH-responsive PDEA-core structure were used as building blocks to construct LbL films using poly(sodium 4-styrenesulfonate) (PSS) as the polymer counterpart. The effect of film deposition pH and temperature on the properties of the multilayers was investigated in detail. It was found that only 0.5-unit difference in the pH of polymer solutions resulted in a significant difference in the stability of the multilayers in the pH-scale. It was also demonstrated that the effect of film deposition temperature on the properties of the resulting films were highly pH-dependent. Results obtained in this thesis study contribute to the fundamental knowledge about the effect of film deposition conditions on the properties of multilayer films of a dually responsive BCM.