Akademik Veri Yönetim Sistemi
Tezin Türü: Doktora
Tezin Yürütüldüğü Kurum: Orta Doğu Teknik Üniversitesi, Türkiye
Tezin Onay Tarihi: 2009
Tezin Dili: İngilizce
Öğrenci: Tuncay Baydemir
Danışman: ERDAL BAYRAMLI
Özet:The use of various biodegradable polymers for the improvement of different controlled and long-lasting drug release systems is an active research area in recent years. The application of different metal prostheses, especially titanium based ones, to the human body is also very common. A most important disadvantage of these prostheses is the risk of infection at the application areas that necessitates the removing of the prosthesis with a second surgical operation and reapplication of it after recovery. One of the best ways to solve this problem is to render metal prostheses infection free with controlled and sustainable drug (antibiotic) release systems. The long term sustained release of relevant antibiotics from the various biodegradable polymer coated metal implants is studied in this thesis. Virtual fatigue analysis and drug loading capacities of titanium and stainless steel samples with different surface pattern and modifications were studied. Various biodegradable polymer and drug combinations were examined and used for coating of metal prosthesis. The aim is to design polymer-drug coated metal implants that are capable of releasing a feasible amount of drug up to a period of at least 1 month. Various coating techniques and surface modifications were also employed to improve the adhesional properties of the drug containing polymers. Their adhesion abilities on the metal substrates were tested by Lap-shear and T-peel tests. Polymer degradation kinetics was followed by viscosity studies. Calibration lines for different drugs were obtained and drug releases on different systems were followed by using UV spectroscopy and microbial antibiotic sensitivity tests. Among the techniques applied to prevent fast release of drugs initially, the coatings of Vancomycin absorbed β-TCP (β-tricalcium phosphate) homogeneously distributed in poly(D,L-lactide-co-glycolide) solution in chloroform followed by an inert coating with poly(L-lactide) system proved to be feasible. By this technique, initial burst release was minimized and drug release from implants lasted nearly 2 months. Multiple coatings on polymer plus drug coating layer also gave promising results. In vivo studies on dorsal muscles of native rabbits with antibiotic loaded implants gave no negative effect on the surrounding tissues with high compatibility free of infection.