The role of genetic manipulation and in situ modifications on production of bacterial nanocellulose: A review

Moradi M., Jacek P., Farhangfar A., Guimarães J. T., FOROUGH M.

International Journal of Biological Macromolecules, vol.183, pp.635-650, 2021 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Review
  • Volume: 183
  • Publication Date: 2021
  • Doi Number: 10.1016/j.ijbiomac.2021.04.173
  • Journal Name: International Journal of Biological Macromolecules
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, Biotechnology Research Abstracts, CAB Abstracts, Chemical Abstracts Core, EMBASE, Food Science & Technology Abstracts, INSPEC, MEDLINE, Veterinary Science Database
  • Page Numbers: pp.635-650
  • Keywords: Bacterial cellulose, Biomaterials, Gluconacetobacter, Omics approaches, Response surface methodology, GLUCOSE-DEHYDROGENASE GENE, CELLULOSE PRODUCTION, GLUCONACETOBACTER-XYLINUS, ACETOBACTER-XYLINUM, MECHANICAL-PROPERTIES, ENHANCED PRODUCTION, ESCHERICHIA-COLI, LAMBDA RED, OPTIMIZATION, WASTE
  • Middle East Technical University Affiliated: Yes

Abstract

© 2021 Elsevier B.V.Natural polysaccharides are well-known biomaterials because of their availability and low-cost, with applications in diverse fields. Cellulose, a renowned polysaccharide, can be obtained from different sources including plants, algae, and bacteria, but recently much attention has been paid to the microorganisms due to their potential of producing renewable compounds. In this regard, bacterial nanocellulose (BNC) is a novel type of nanocellulose material that is commercially synthesized mainly by Komagataeibacter spp. Characteristics such as purity, porosity, and remarkable mechanical properties made BNC a superior green biopolymer with applications in pharmacology, biomedicine, bioprocessing, and food. Genetic manipulation of BNC-producing strains and in situ modifications of the culturing conditions can lead to BNC with enhanced yield/productivity and properties. This review mainly highlights the role of genetic engineering of Komagataeibacter strains and co-culturing of bacterial strains with additives such as microorganisms and nanomaterials to synthesize BNC with improved functionality and productivity rate.