Enzymatic resolution of (+/-)-2-endo-hydroxymethyl and acetoxymethyl substituted hexachloronorbornene derivatives


TÜRKMEN Y. E. , Akhmedov I., Tanyeli C.

TETRAHEDRON-ASYMMETRY, cilt.16, ss.2315-2318, 2005 (SCI İndekslerine Giren Dergi) identifier identifier

  • Cilt numarası: 16 Konu: 13
  • Basım Tarihi: 2005
  • Doi Numarası: 10.1016/j.tetasy.2005.06.014
  • Dergi Adı: TETRAHEDRON-ASYMMETRY
  • Sayfa Sayıları: ss.2315-2318

Özet

(+/-)-2-endo-Hydroxymethyl-1,4,5,6,7,7-hexachlorobicyclo[2.2.1]hept-5-ene and (+/-)-2-endo-acetoxymethyl-1,4,5,6,7,7hexachlorobicyclo[2.2.1]hept-5-ene were resolved by using various hydrolases to afford enantiomerically enriched products with ees of 94-98%. The absolute configuration was determined by transforming 2-endo-acetoxymethyl-1,4,5,6,7,7-hexachlorobicyclo[2.2.1]hept-5-ene into 2-endo-hydroxymetliyl-bicyclo[2.2.1]hept-5-ene with known absolute configuration. (c) 2005 Elsevier Ltd. All rights reserved.