ADVANCED SYNTHESIS & CATALYSIS, vol.353, no.4, pp.624-629, 2011 (Journal Indexed in SCI)
Article / Article
Title of Journal :
ADVANCED SYNTHESIS & CATALYSIS
amidation reaction, enzyme catalysis, hydroxamic acids, thiamine diphosphate-dependent enzyme, ALPHA-KETOGLUTARATE DEHYDROGENASE, HYDROXAMIC ACID PRODUCTION, N-ARYLHYDROXAMIC ACIDS, AROMATIC-COMPOUNDS, ARYL, REDUCTION, OXIDATION
Benzaldehyde lyase from the Pseudomonas fluorescens catalyzes the reaction of aromatic aldehydes with nitroso compounds and furnishes N-arylhydroxamic acids in high yields. Aromatic aldehydes and benzoins are converted into enamine-carbanion-like intermediates prior to their reaction with nitroso compounds. The kinetic resolution of rac-2-hydroxy-1,2-diphenylethanones furnished (S)-benzoins and arylhydroxamic acids with high enantioselectivities and conversions.