Complete chemical and structural characterization of selenium-incorporated hydroxyapatite


Alkan B., DURUCAN C.

JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE, vol.33, no.1, 2022 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 33 Issue: 1
  • Publication Date: 2022
  • Doi Number: 10.1007/s10856-021-06631-6
  • Title of Journal : JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE

Abstract

Hydroxyapatite (HAp) has long been used as synthetic bone tissue replacement material. Recent advances in this area have led to development of dual-functional bioceramics exhibiting high biocompability/osteoconductivity together with the therapeutic effect. Selenium, in that respect, is an effective therapeutic agent with promising antioxidant activity and anticancer effects. In this study, selenium-incorporated hydroxyapatite (HAp:Se) particles have been synthesized by modified aqueous precipitation method using calcium (Ca(NO3)(2)center dot 4H(2)O) and phosphate ((NH4)(2)HPO4) salts and sodium selenite (Na2SeO3). The effects of selenium incorporation and post-synthesis calcination treatment (900-1100 degrees C) on physical, chemical properties and crystal structure of resultant HAp powders have been investigated. Complete chemical identification was performed with spectroscopical analyses including Fourier transform infrared and x-ray photoelectron spectroscopy to elucidate the mechanism and chemical nature of selenium incorporation in HAp. Meanwhile, detailed x-ray diffraction studies by Rietveld refinement have conducted to explain changes in the HAp crystal structure upon selenium incorporation.