Hybrid fed-batch bioreactor operation design: control of substrate uptake enhances recombinant protein production in high-cell-density fermentations


ÇALIK P. , Hoxha B., ÇALIK GARCİA G., Ozdamar T. H.

JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY, cilt.93, ss.3326-3335, 2018 (SCI İndekslerine Giren Dergi) identifier identifier

  • Cilt numarası: 93 Konu: 11
  • Basım Tarihi: 2018
  • Doi Numarası: 10.1002/jctb.5696
  • Dergi Adı: JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY
  • Sayfa Sayıları: ss.3326-3335

Özet

BACKGROUNDThe hybrid fed-batch bioreactor (HFBB) operation is a novel design method for high-cell-density fermentations. It employs fed-batch and batch operations, starting with fed-batch that in turn shifts to the next, and proceeds in successive cycles to enhance production and productivity by controlling the substrate uptake rate.