A novel cyclodextrin homodimer with dual-mode substrate binding and esterase activity
JOURNAL OF MOLECULAR CATALYSIS A-CHEMICAL, vol.157, pp.261-263, 2000 (SCI-Expanded, Scopus)
- Publication Type: Article / Letter
- Volume: 157
- Publication Date: 2000
- Doi Number: 10.1016/s1381-1169(00)00159-x
- Journal Name: JOURNAL OF MOLECULAR CATALYSIS A-CHEMICAL
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Page Numbers: pp.261-263
- Middle East Technical University Affiliated: No
Abstract
A novel cyclodextrin homodimer with two beta-cyclodextrin units tethered from the primary side by a tris(2-aminoethyl)amine linker was found to be hydrolytically active. The hydrolysis of a ditopic activated carbonate ester was accelerated 150-fold and a Lineweaver-Burk plot showed a biphasic curve indicative of two different binding modes for the activated carbonate ester. (C) 2000 Elsevier Science B.V. All rights reserved.