Paraoxonase/arylesterase ratio, PON1 192Q/R polymorphism and PON1 status are associated with increased risk of ischernic stroke


Demirdogen B. C. , Turkanoglu A., Bek S., Sanisoglu Y., Demirkaya S., Vural O., ...More

CLINICAL BIOCHEMISTRY, vol.41, pp.1-9, 2008 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 41
  • Publication Date: 2008
  • Doi Number: 10.1016/j.clinbiochem.2007.08.010
  • Journal Name: CLINICAL BIOCHEMISTRY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1-9
  • Keywords: paraoxonase, polymorphism, ischemic stroke, risk factors, genes, atherosclerosis, SERUM PARAOXONASE ACTIVITY, CORONARY-ARTERY-DISEASE, LOW-DENSITY-LIPOPROTEIN, MYOCARDIAL-INFARCTION, GENE POLYMORPHISMS, OXIDATIVE STRESS, VASCULAR-DISEASE, HEART-DISEASE, HUMPONA GENE, ARYLESTERASE
  • Middle East Technical University Affiliated: Yes

Abstract

Objectives: In recent years, importance of enzyme activity measurements, in addition to genotyping, in epidemiological studies relating paraoxonase 1 (PON1) and vascular disease was emphasized. This is the first report evaluating paraoxonase and arylesterase activities as risk factors for ischemic stroke. In addition, PON1 192Gln(Q)/Arg(R) and 55Leu(L)/Met(M) polymorphisms were also analyzed.