Paraoxonase/arylesterase ratio, PON1 192Q/R polymorphism and PON1 status are associated with increased risk of ischernic stroke


Demirdogen B. C. , Turkanoglu A., Bek S., Sanisoglu Y., Demirkaya S., Vural O., ...Daha Fazla

CLINICAL BIOCHEMISTRY, cilt.41, ss.1-9, 2008 (SCI İndekslerine Giren Dergi) identifier identifier identifier

Özet

Objectives: In recent years, importance of enzyme activity measurements, in addition to genotyping, in epidemiological studies relating paraoxonase 1 (PON1) and vascular disease was emphasized. This is the first report evaluating paraoxonase and arylesterase activities as risk factors for ischemic stroke. In addition, PON1 192Gln(Q)/Arg(R) and 55Leu(L)/Met(M) polymorphisms were also analyzed.