Paraoxonase/arylesterase ratio, PON1 192Q/R polymorphism and PON1 status are associated with increased risk of ischernic stroke

Demirdogen B. C., Turkanoglu A., Bek S., Sanisoglu Y., Demirkaya S., Vural O., ...Daha Fazla

CLINICAL BIOCHEMISTRY, cilt.41, ss.1-9, 2008 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 41
  • Basım Tarihi: 2008
  • Doi Numarası: 10.1016/j.clinbiochem.2007.08.010
  • Dergi Adı: CLINICAL BIOCHEMISTRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1-9
  • Anahtar Kelimeler: paraoxonase, polymorphism, ischemic stroke, risk factors, genes, atherosclerosis, SERUM PARAOXONASE ACTIVITY, CORONARY-ARTERY-DISEASE, LOW-DENSITY-LIPOPROTEIN, MYOCARDIAL-INFARCTION, GENE POLYMORPHISMS, OXIDATIVE STRESS, VASCULAR-DISEASE, HEART-DISEASE, HUMPONA GENE, ARYLESTERASE
  • Orta Doğu Teknik Üniversitesi Adresli: Evet

Özet

Objectives: In recent years, importance of enzyme activity measurements, in addition to genotyping, in epidemiological studies relating paraoxonase 1 (PON1) and vascular disease was emphasized. This is the first report evaluating paraoxonase and arylesterase activities as risk factors for ischemic stroke. In addition, PON1 192Gln(Q)/Arg(R) and 55Leu(L)/Met(M) polymorphisms were also analyzed.