PHARMACEUTICAL BIOLOGY, vol.51, no.5, pp.650-658, 2013 (SCI-Expanded)
Article / Article
Science Citation Index Expanded (SCI-EXPANDED), Scopus
Cytochrome P450, drug metabolism, glutathione peroxidase, liver enzymes, medicinal plant, NQO1, onagraceae, NAD(P)H-QUINONE OXIDOREDUCTASE 1, NAD(P)H QUINONE OXIDOREDUCTASE, GLUTATHIONE-S-TRANSFERASE, N-NITROSODIMETHYLAMINE, OXIDATIVE STRESS, DT-DIAPHORASE, LIVER, LUNG, ENZYMES, SUSCEPTIBILITY
Middle East Technical University Affiliated:
Context: Natural products have attracted increasing interests due to their use in flavoring, nutrition, cosmetics, pharmacy and medicine. Epilobium hirsutum L. (Onagraceae) is known for its analgesic, antimicrobial, and antiproliferative activity. CYP1A1 and CYP2E1, xenobiotic metabolizing enzymes, serve as a metabolic activation route yielding reactive metabolites that are eliminated by the action of NQO1 and glutathione peroxidase (GPx) enzymes.