Epilobium hirsutum alters xenobiotic metabolizing CYP1A1, CYP2E1, NQO1 and GPx activities, mRNA and protein levels in rats

Karakurt S., SEMİZ A., Celik G., GENÇLER ÖZKAN A. M., ŞEN A., ADALI O.

PHARMACEUTICAL BIOLOGY, vol.51, no.5, pp.650-658, 2013 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 51 Issue: 5
  • Publication Date: 2013
  • Doi Number: 10.3109/13880209.2012.762404
  • Journal Name: PHARMACEUTICAL BIOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.650-658
  • Keywords: Cytochrome P450, drug metabolism, glutathione peroxidase, liver enzymes, medicinal plant, NQO1, onagraceae, NAD(P)H-QUINONE OXIDOREDUCTASE 1, NAD(P)H QUINONE OXIDOREDUCTASE, GLUTATHIONE-S-TRANSFERASE, N-NITROSODIMETHYLAMINE, OXIDATIVE STRESS, DT-DIAPHORASE, LIVER, LUNG, ENZYMES, SUSCEPTIBILITY
  • Middle East Technical University Affiliated: Yes

Abstract

Context: Natural products have attracted increasing interests due to their use in flavoring, nutrition, cosmetics, pharmacy and medicine. Epilobium hirsutum L. (Onagraceae) is known for its analgesic, antimicrobial, and antiproliferative activity. CYP1A1 and CYP2E1, xenobiotic metabolizing enzymes, serve as a metabolic activation route yielding reactive metabolites that are eliminated by the action of NQO1 and glutathione peroxidase (GPx) enzymes.