Epilobium hirsutum alters xenobiotic metabolizing CYP1A1, CYP2E1, NQO1 and GPx activities, mRNA and protein levels in rats

Karakurt S., SEMİZ A., Celik G., GENÇLER ÖZKAN A. M., ŞEN A., ADALI O.

PHARMACEUTICAL BIOLOGY, cilt.51, sa.5, ss.650-658, 2013 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 51 Sayı: 5
  • Basım Tarihi: 2013
  • Doi Numarası: 10.3109/13880209.2012.762404
  • Dergi Adı: PHARMACEUTICAL BIOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.650-658
  • Anahtar Kelimeler: Cytochrome P450, drug metabolism, glutathione peroxidase, liver enzymes, medicinal plant, NQO1, onagraceae, NAD(P)H-QUINONE OXIDOREDUCTASE 1, NAD(P)H QUINONE OXIDOREDUCTASE, GLUTATHIONE-S-TRANSFERASE, N-NITROSODIMETHYLAMINE, OXIDATIVE STRESS, DT-DIAPHORASE, LIVER, LUNG, ENZYMES, SUSCEPTIBILITY
  • Orta Doğu Teknik Üniversitesi Adresli: Evet

Özet

Context: Natural products have attracted increasing interests due to their use in flavoring, nutrition, cosmetics, pharmacy and medicine. Epilobium hirsutum L. (Onagraceae) is known for its analgesic, antimicrobial, and antiproliferative activity. CYP1A1 and CYP2E1, xenobiotic metabolizing enzymes, serve as a metabolic activation route yielding reactive metabolites that are eliminated by the action of NQO1 and glutathione peroxidase (GPx) enzymes.