Effects of prenatal binge-like ethanol exposure and maternal stress on postnatal morphological development of hippocampal neurons in rats


Jakubowska-Dogru E., Elibol B., Dursun I., Yuruker S.

INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE, vol.61, pp.40-50, 2017 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 61
  • Publication Date: 2017
  • Doi Number: 10.1016/j.ijdevneu.2017.06.002
  • Journal Name: INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.40-50
  • Keywords: Prenatal ethanol intoxication, Maternal stress during gestation, Hippocampus, Neuronal morphometry, Rat, CA1 PYRAMIDAL NEURONS, FETAL ALCOHOL EXPOSURE, NERVE GROWTH-FACTOR, DENDRITIC SPINES, MODERATE LEVELS, FRONTAL-CORTEX, ADULT, PLASTICITY, INTUBATION, SYNAPSES
  • Middle East Technical University Affiliated: Yes

Abstract

Background: Alcohol is one of the most commonly used drugs of abuse negatively affecting human health and it is known as a potent teratogen responsible for fetal alcohol syndrome (FAS), which is characterized by cognitive deficits especially pronounced in juveniles but ameliorating in adults. Searching for the potential morphological correlates of these effects, in this study, we compared the course of developmental changes in the morphology of principal hippocampal neurons in fetal-alcohol (A group), intubated control (IC group), and intact control male rats (C group) over a protracted period of the first two postnatal months.