Effects of prenatal binge-like ethanol exposure and maternal stress on postnatal morphological development of hippocampal neurons in rats


Jakubowska-Dogru E., Elibol B., Dursun I., Yuruker S.

INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE, cilt.61, ss.40-50, 2017 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 61
  • Basım Tarihi: 2017
  • Doi Numarası: 10.1016/j.ijdevneu.2017.06.002
  • Dergi Adı: INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE
  • Sayfa Sayıları: ss.40-50

Özet

Background: Alcohol is one of the most commonly used drugs of abuse negatively affecting human health and it is known as a potent teratogen responsible for fetal alcohol syndrome (FAS), which is characterized by cognitive deficits especially pronounced in juveniles but ameliorating in adults. Searching for the potential morphological correlates of these effects, in this study, we compared the course of developmental changes in the morphology of principal hippocampal neurons in fetal-alcohol (A group), intubated control (IC group), and intact control male rats (C group) over a protracted period of the first two postnatal months.