Integromic Analysis of Genetic Variation and Gene Expression Identifies Networks for Cardiovascular Disease Phenotypes

Creative Commons License

Yao C., Chen B. H., Joehanes R., Otlu B., Zhang X., Liu C., ...Daha Fazla

CIRCULATION, cilt.131, sa.6, ss.536-746, 2015 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 131 Sayı: 6
  • Basım Tarihi: 2015
  • Doi Numarası: 10.1161/circulationaha.114.010696
  • Dergi Adı: CIRCULATION
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.536-746
  • Anahtar Kelimeler: cardiovascular disease, gene expression/regulation network, genetic variation, GENOME-WIDE ASSOCIATION, CORONARY-HEART-DISEASE, SMOKING-BEHAVIOR, LOCI, VARIANTS, RISK, CYTOSCAPE, DISCOVERY, TRAITS, MODELS
  • Orta Doğu Teknik Üniversitesi Adresli: Evet

Özet

Background-Cardiovascular disease (CVD) reflects a highly coordinated complex of traits. Although genome-wide association studies have reported numerous single nucleotide polymorphisms (SNPs) to be associated with CVD, the role of most of these variants in disease processes remains unknown.