Integromic Analysis of Genetic Variation and Gene Expression Identifies Networks for Cardiovascular Disease Phenotypes

Yao, Chen; Chen, Brian; Joehanes, Roby; Otlu, BURÇAK; Zhang, Xiaoling; Liu, Chunyu; Huan, Tianxiao; Tastan, Oznur; Cupples, L.; Meigs, James; Fox, Caroline; Freedman, Jane; Courchesne, Paul; O'Donnell, Christopher; Munson, Peter; Keles, Sunduz; Levy, Daniel

doi:10.1161/circulationaha.114.010696

Integromic Analysis of Genetic Variation and Gene Expression Identifies Networks for Cardiovascular Disease Phenotypes

Yao C., Chen B. H., Joehanes R., Otlu B., Zhang X., Liu C., ...Daha Fazla

CIRCULATION, cilt.131, sa.6, ss.536-746, 2015 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 131 Sayı: 6
Basım Tarihi: 2015
Doi Numarası: 10.1161/circulationaha.114.010696
Dergi Adı: CIRCULATION
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.536-746
Anahtar Kelimeler: cardiovascular disease, gene expression/regulation network, genetic variation, GENOME-WIDE ASSOCIATION, CORONARY-HEART-DISEASE, SMOKING-BEHAVIOR, LOCI, VARIANTS, RISK, CYTOSCAPE, DISCOVERY, TRAITS, MODELS
Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
Orta Doğu Teknik Üniversitesi Adresli: Evet

Özet

Background-Cardiovascular disease (CVD) reflects a highly coordinated complex of traits. Although genome-wide association studies have reported numerous single nucleotide polymorphisms (SNPs) to be associated with CVD, the role of most of these variants in disease processes remains unknown.