mmm: An R package for analyzing multivariate longitudinal data with multivariate marginal models

Asar O., İLK DAĞ Ö.

COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE, vol.112, no.3, pp.649-654, 2013 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 112 Issue: 3
  • Publication Date: 2013
  • Doi Number: 10.1016/j.cmpb.2013.07.022
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.649-654
  • Keywords: Correlated data, Multiple outcomes, Medical studies, Package presentation, Population-averaged inference, Statistical software, REGRESSION, RESPONSES, DISCRETE, DECLINE
  • Middle East Technical University Affiliated: Yes


Modeling multivariate longitudinal data has many challenges in terms of both statistical and computational aspects. Statistical challenges occur due to complex dependence structures. Computational challenges are due to the complex algorithms, the use of numerical methods, and potential convergence problems. Therefore, there is a lack of software for such data. This paper introduces an R package mmm prepared for marginal modeling of multivariate longitudinal data. Parameter estimations are achieved by generalized estimating equations approach. A real life data set is applied to illustrate the core features of the package, and sample R code snippets are provided. It is shown that the multivariate marginal models considered in this paper and mmm are valid for binary, continuous and count multivariate longitudinal responses. (c) 2013 Elsevier Ireland Ltd. All rights reserved.