Anterior mitral leaflet curvature in the beating ovine heart: a case study using videofluoroscopic markers and subdivision surfaces

GÖKTEPE S., Bothe W., Kvitting J., Swanson J., Ingels N., Miller C., ...Daha Fazla

BIOMECHANICS AND MODELING IN MECHANOBIOLOGY, cilt.9, sa.3, ss.281-293, 2010 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 9 Sayı: 3
  • Basım Tarihi: 2010
  • Doi Numarası: 10.1007/s10237-009-0176-z
  • Dergi Adı: BIOMECHANICS AND MODELING IN MECHANOBIOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.281-293
  • Anahtar Kelimeler: Mitral valve, Mitral regurgitation, Annuloplasty ring, Curvature, Subdivision surfaces, Continuity, FINITE-ELEMENT-ANALYSIS, VALVE LEAFLETS, IN-VIVO, STRESS, DEFORMATION, ALGORITHMS, GEOMETRY, BEHAVIOR, SHAPE
  • Orta Doğu Teknik Üniversitesi Adresli: Evet

Özet

The implantation of annuloplasty rings is a common surgical treatment targeted to re-establish mitral valve competence in patients with mitral regurgitation. It is hypothesized that annuloplasty ring implantation influences leaflet curvature, which in turn may considerably impair repair durability. This research is driven by the vision to design repair devices that optimize leaflet curvature to reduce valvular stress. In pursuit of this goal, the objective of this manuscript is to quantify leaflet curvature in ovine models with and without annuloplasty ring using in vivo animal data from videofluoroscopic marker analysis. We represent the surface of the anterior mitral leaflet based on 23 radiopaque markers using subdivision surfaces techniques. Quartic box-spline functions are applied to determine leaflet curvature on overlapping subdivision patches. We illustrate the virtual reconstruction of the leaflet surface for both interpolating and approximating algorithms. Different scalar-valued metrics are introduced to quantify leaflet curvature in the beating heart using the approximating subdivision scheme. To explore the impact of annuloplasty ring implantation, we analyze ring-induced curvature changes at characteristic instances throughout the cardiac cycle. The presented results demonstrate that the fully automated subdivision surface procedure can successfully reconstruct a smooth representation of the anterior mitral valve from a limited number of markers at a high temporal resolution of approximately 60 frames per minute.