TFA catalyzed sequential amination/annulation/aromatization reaction of 2-propynyl-1.3-dicarbonyl compounds with amines: a new one-pot approach to functionalized pyrroles

Demir A. , Aybey A., Kayalar M.

ARKIVOC, ss.105-116, 2005 (SCI İndekslerine Giren Dergi) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Basım Tarihi: 2005
  • Dergi Adı: ARKIVOC
  • Sayfa Sayıları: ss.105-116


Highly flexible and efficient syntheses of 1,2,3,5- substituted pyrroles starting from 2- propynyl-1,3- dicarbonyl compounds and amines are presented. TFA catalyzed formation of the pyrroles is suggested to proceed through sequential amination of the carbonyl compounds followed by regioselective 5- exo- dig cyclization of the enaminone intermediate and aromatization.