Bone tissue engineering on patterned collagen films: an in vitro study

Ber S., Kose G., Hasirci V.

BIOMATERIALS, vol.26, no.14, pp.1977-1986, 2005 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 26 Issue: 14
  • Publication Date: 2005
  • Doi Number: 10.1016/j.biomaterials.2004.07.007
  • Journal Name: BIOMATERIALS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1977-1986
  • Keywords: tissue engineering, micropatterned surfaces, cell orientation, osteoblasts, collagen, BEHAVIOR
  • Middle East Technical University Affiliated: Yes


This study aimed at guiding osteoblast cells from rat bone marrow on chemically modified and patterned collagen films to study the influence of pattern, on cell guidance. The films were stabilized using different treatment methods including crosslinking with carbodiimide (EDC) and glutaraldehyde, dehydrothermal treatment (DHT), and deposition of calcium phosphate on the collagen membrane.