(In)Distinctive Role of Long Non-Coding RNAs in Common and Rare Ovarian Cancers


Sabol M., Calleja-Agius J., Di Fiore R., Suleiman S., ÖZCAN KABASAKAL S., Ward M. P. , ...More

CANCERS, vol.13, no.20, 2021 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Review
  • Volume: 13 Issue: 20
  • Publication Date: 2021
  • Doi Number: 10.3390/cancers13205040
  • Journal Name: CANCERS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, CAB Abstracts, CINAHL, EMBASE, Veterinary Science Database, Directory of Open Access Journals
  • Keywords: rare ovarian cancers, long non-coding RNAs, lncRNAs, competing endogenous RNA, ceRNA, MALAT1, ovarian cancer biomarkers, lncRNA-based therapy, COMPETING ENDOGENOUS RNA, INHIBITS CELL VIABILITY, REGULATED LNCRNA NEAT1, CISPLATIN-RESISTANCE, POOR-PROGNOSIS, STEM-CELLS, PACLITAXEL RESISTANCE, IMPRINTING ANALYSIS, PROMOTES APOPTOSIS, MODULAR SCAFFOLD
  • Middle East Technical University Affiliated: Yes

Abstract

Simple Summary:& nbsp;Ovarian cancers (OCs) are the most lethal form of gynecological tumors. The commonest are high-grade serous OCs, while rare OCs originate from many different cell types, such as epithelial, germ cell, sex cord-stromal, or mixed types. Rare OCs have distinct molecular characteristics, prognosis, and therapeutic approaches. However, all ovarian malignancies mostly share the same problem: late diagnosis due to the lack of specific symptoms. Therefore, there is a perpetual need to discover better diagnostic, prognostic, and predictive biomarkers, as well as new therapeutic approaches. In recent years, long non-coding RNAs (lncRNAs) have gained widespread attention because of their important role in various biological pathways. They have multiple mechanisms of action with an important role in many cellular processes related to OCs development and progression. This review will focus on the different aspects of lncRNAs in OCs and attempt to highlight the distinctive role of lncRNAs in common and rare OCs.