LFM-Pro: a tool for detecting significant local structural sites in proteins

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Sacan A., Ozturk O., Ferhatosmanoglu H., Wang Y.

BIOINFORMATICS, cilt.23, sa.6, ss.709-716, 2007 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 23 Konu: 6
  • Basım Tarihi: 2007
  • Doi Numarası: 10.1093/bioinformatics/btl685
  • Sayfa Sayıları: ss.709-716


Motivation: The rapidly growing protein structure repositories have opened up new opportunities for discovery and analysis of functional and evolutionary relationships among proteins. Detecting conserved structural sites that are unique to a protein family is of great value in identification of functionally important atoms and residues. Currently available methods are computationally expensive and fail to detect biologically significant local features.