LFM-Pro: a tool for detecting significant local structural sites in proteins

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Sacan A., Ozturk O., Ferhatosmanoglu H., Wang Y.

BIOINFORMATICS, vol.23, no.6, pp.709-716, 2007 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 23 Issue: 6
  • Publication Date: 2007
  • Doi Number: 10.1093/bioinformatics/btl685
  • Journal Name: BIOINFORMATICS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.709-716
  • Middle East Technical University Affiliated: No


Motivation: The rapidly growing protein structure repositories have opened up new opportunities for discovery and analysis of functional and evolutionary relationships among proteins. Detecting conserved structural sites that are unique to a protein family is of great value in identification of functionally important atoms and residues. Currently available methods are computationally expensive and fail to detect biologically significant local features.