The effect of the double bond pyramidalization on the mode of the bromination reaction: Bromination of benzobicyclononadiene

Balci M., Guney M., Dastan A., Azizoglu A.

JOURNAL OF ORGANIC CHEMISTRY, vol.72, no.13, pp.4756-4762, 2007 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 72 Issue: 13
  • Publication Date: 2007
  • Doi Number: 10.1021/jo070253b
  • Journal Name: JOURNAL OF ORGANIC CHEMISTRY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.4756-4762
  • Middle East Technical University Affiliated: No

Abstract

The bromination of 6,7,8,9-tetrahydro-5H-5,9-ethenobenzo[a][7]annulene yielded regio- and stereospecifically formed dibromides arising from the alkyl shift where the bromine exclusively attacks the double bond from the endo face of the double bond. DFT calculations on model compounds showed that the pyramidalization of the double bond and steric repulsion caused by the methylene protons are responsible for the stereo- and regioselective addition of bromine.