Metabolism of methimazole by bovine liver microsomal flavine monooxygenase: modulation by imipramine and chlorpromazine, comparison with sheep enzyme

Aktas D. F., Demirdogen B. C., ADALI O.

TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI, cilt.34, sa.1, ss.44-50, 2009 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 34 Sayı: 1
  • Basım Tarihi: 2009
  • Dergi Adı: TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.44-50
  • Orta Doğu Teknik Üniversitesi Adresli: Evet

Özet

Aim: Veterinary animals are exposed to a variety of xenobiotics. Methimazole is an anti thyroid drug which has been illegally used as a fattening agent in cattle and imipramine and chlorpromazine are antidepressant drugs. In the present study, the aim was to study metabolism of these three drugs by cattle liver microsomes and to characterize biochemical and kinetic properties of bovine liver microsomal flavin-containing monooxygenase catalyzed methimazole oxidation.