Metabolism of methimazole by bovine liver microsomal flavine monooxygenase: modulation by imipramine and chlorpromazine, comparison with sheep enzyme

Aktas D. F., Demirdogen B. C., ADALI O.

TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI, vol.34, no.1, pp.44-50, 2009 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 34 Issue: 1
  • Publication Date: 2009
  • Journal Name: TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.44-50
  • Middle East Technical University Affiliated: Yes

Abstract

Aim: Veterinary animals are exposed to a variety of xenobiotics. Methimazole is an anti thyroid drug which has been illegally used as a fattening agent in cattle and imipramine and chlorpromazine are antidepressant drugs. In the present study, the aim was to study metabolism of these three drugs by cattle liver microsomes and to characterize biochemical and kinetic properties of bovine liver microsomal flavin-containing monooxygenase catalyzed methimazole oxidation.