Quantitative structure-activity relationship study of some 7-substituted theophyllines


Turker L., Akgun H., Balkan A.

ARZNEIMITTEL-FORSCHUNG-DRUG RESEARCH, vol.48, no.1, pp.39-42, 1998 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 48 Issue: 1
  • Publication Date: 1998
  • Title of Journal : ARZNEIMITTEL-FORSCHUNG-DRUG RESEARCH
  • Page Numbers: pp.39-42

Abstract

Some novel 7-substituted theophylline derivatives have been investigated for quantitative structure-activity relationship (QSAR). For this purpose, their bronchodilatory activities (in vitro), which were examined by the inhibition of acetylcholine induced contraction in tracheae isolated from guinea pigs, have been correlated with various quantum chemical and physicochemical parameters.