Quantitative structure-activity relationship study of some 7-substituted theophyllines

Turker L., Akgun H., Balkan A.

ARZNEIMITTEL-FORSCHUNG-DRUG RESEARCH, cilt.48, sa.1, ss.39-42, 1998 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 48 Sayı: 1
  • Basım Tarihi: 1998
  • Dergi Adı: ARZNEIMITTEL-FORSCHUNG-DRUG RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.39-42
  • Orta Doğu Teknik Üniversitesi Adresli: Hayır

Özet

Some novel 7-substituted theophylline derivatives have been investigated for quantitative structure-activity relationship (QSAR). For this purpose, their bronchodilatory activities (in vitro), which were examined by the inhibition of acetylcholine induced contraction in tracheae isolated from guinea pigs, have been correlated with various quantum chemical and physicochemical parameters.