Sample preparation with solid phase microextraction and exhaustive extraction approaches: Comparison for challenging cases

Boyaci E., Rodriguez-Lafuente A., Gorynski K., Mirnaghi F., Souza-Silva E. A., Hein D., ...Daha Fazla

ANALYTICA CHIMICA ACTA, cilt.873, ss.14-30, 2015 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 873
  • Basım Tarihi: 2015
  • Doi Numarası: 10.1016/j.aca.2014.12.051
  • Dergi Adı: ANALYTICA CHIMICA ACTA
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.14-30
  • Anahtar Kelimeler: Sample preparation, On-site/in vivo analysis, Complex matrices/challenging compounds, Solid phase microextraction, Liquid-liquid extraction, Solid phase extraction, CHROMATOGRAPHY-MASS-SPECTROMETRY, LIQUID-LIQUID-EXTRACTION, POLYCYCLIC AROMATIC-HYDROCARBONS, VOLATILE ORGANIC-COMPOUNDS, THIN-FILM MICROEXTRACTION, QUATERNARY AMMONIUM-COMPOUNDS, POSTMORTEM WHOLE-BLOOD, HOT-WATER EXTRACTION, SPME-GC-MS, GAS-CHROMATOGRAPHY
  • Orta Doğu Teknik Üniversitesi Adresli: Hayır

Özet

In chemical analysis, sample preparation is frequently considered the bottleneck of the entire analytical method. The success of the final method strongly depends on understanding the entire process of analysis of a particular type of analyte in a sample, namely: the physicochemical properties of the analytes (solubility, volatility, polarity etc.), the environmental conditions, and the matrix components of the sample. Various sample preparation strategies have been developed based on exhaustive or non-exhaustive extraction of analytes from matrices. Undoubtedly, amongst all sample preparation approaches, liquid extraction, including liquid-liquid (LLE) and solid phase extraction (SPE), are the most well-known, widely used, and commonly accepted methods by many international organizations and accredited laboratories. Both methods are well documented and there are many well defined procedures, which make them, at first sight, the methods of choice. However, many challenging tasks, such as complex matrix applications, on-site and in vivo applications, and determination of matrix-bound and free concentrations of analytes, are not easily attainable with these classical approaches for sample preparation.