Basic fibroblast growth factor loaded polypropylene meshes in repair of abdominal wall defects in rats


Heybeli T., Kulacoglu H., GENÇ V., Ergul Z., Ensari C., Kiziltay A. , ...More

CHIRURGIA, vol.105, no.6, pp.809-816, 2010 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 105 Issue: 6
  • Publication Date: 2010
  • Title of Journal : CHIRURGIA
  • Page Numbers: pp.809-816
  • Keywords: growth factor, fibroblast, FGF, wound healing, abdominal wall, incisional hernia, hernia repair, mesh, RANDOMIZED CONTROLLED-TRIAL, TERM-FOLLOW-UP, INCISIONAL HERNIA, RELEASE, SUTURE, ULCERS

Abstract

Background and Aim: Incisional hernia following laparotomy and recurrent herniation after its repair are still common problems in spite of mesh augmentation. The underlying biological mechanism may be related to collagen metabolism. Recently, some members of growth factors family have been tested in the prevention of wound failure and incisonal hernia formation. Growth factors may promote fibroblast proliferation and collagen deposition. In the present study, we searched the effects of basic fibroblast growth factor (bFGF) loaded polypropylene meshes in an incisional hernia model in rats.