Synthesis of novel chiral bisoxazoline ligands with a norbornadiene backbone: use in the copper-catalyzed enantioselective Henry reaction

Delikus, Rabia; Cakir, Emine; DEMİREL, NADİR; BALCI, METİN; KARATAŞ, BETÜL

doi:10.3906/kim-1504-80

Synthesis of novel chiral bisoxazoline ligands with a norbornadiene backbone: use in the copper-catalyzed enantioselective Henry reaction

Delikus R., Cakir E., DEMİREL N., BALCI M., KARATAŞ B.

TURKISH JOURNAL OF CHEMISTRY, cilt.40, sa.2, ss.248-261, 2016 (SCI-Expanded, Scopus, TRDizin)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 40 Sayı: 2
Basım Tarihi: 2016
Doi Numarası: 10.3906/kim-1504-80
Dergi Adı: TURKISH JOURNAL OF CHEMISTRY
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
Sayfa Sayıları: ss.248-261
Orta Doğu Teknik Üniversitesi Adresli: Hayır

Özet

Novel chiral bisoxazoline ligands based on norbornadiene were synthesized and used for the asymmetric Henry reaction. Various aromatic aldehydes were converted into chiral beta-nitro alcohols with high yields and moderate to acceptable enantioselectivities under the optimized reaction conditions.