Zebrafish optomotor response to second-order motion illustrates that age-related changes in motion detection depend on the activated motion system

Karaduman A., Karoglu-Eravsar E. T., Kaya U., AYDIN A., Adams M. M., Kafaligonul H.

Neurobiology of Aging, cilt.130, ss.12-21, 2023 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 130
  • Basım Tarihi: 2023
  • Doi Numarası: 10.1016/j.neurobiolaging.2023.06.005
  • Dergi Adı: Neurobiology of Aging
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Abstracts in Social Gerontology, BIOSIS, CAB Abstracts, EMBASE, MEDLINE, Psycinfo, Veterinary Science Database
  • Sayfa Sayıları: ss.12-21
  • Anahtar Kelimeler: Acetylcholinesterase, Aging, Motion detection, Second-order motion, Zebrafish
  • Orta Doğu Teknik Üniversitesi Adresli: Evet

Özet

Various aspects of visual functioning, including motion perception, change with age. Yet, there is a lack of comprehensive understanding of age-related alterations at different stages of motion processing and in each motion system. To understand the effects of aging on second-order motion processing, we investigated optomotor responses (OMR) in younger and older wild-type (AB-strain) and acetylcholinesterase (achesb55/+) mutant zebrafish. The mutant fish with decreased levels of acetylcholinesterase have been shown to have delayed age-related cognitive decline. Compared to previous results on first-order motion, we found distinct changes in OMR to second-order motion. The polarity of OMR was dependent on age, such that second-order stimulation led to mainly negative OMR in the younger group while older zebrafish had positive responses. Hence, these findings revealed an overall aging effect on the detection of second-order motion. Moreover, neither the genotype of zebrafish nor the spatial frequency of motion significantly changed the response magnitude. Our findings support the view that age-related changes in motion detection depend on the activated motion system.