Synergistic Mn3O4/acetylene black interface for stable and sensitive electrochemical detection of sertraline hydrochloride
Journal of Electroanalytical Chemistry, cilt.1020, 2026 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 1020
- Basım Tarihi: 2026
- Doi Numarası: 10.1016/j.jelechem.2026.120470
- Dergi Adı: Journal of Electroanalytical Chemistry
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Chemical Abstracts Core, Chimica, Compendex, INSPEC
- Anahtar Kelimeler: Acetylene black, Antidepressant drug, Electrochemical sensor, Mn3O4, Screen-printed carbon electrode, Sertraline hydrochloride
- Orta Doğu Teknik Üniversitesi Adresli: Evet
Özet
This study presents an electrochemical sensor built on a Mn3O4/acetylene black (AB) nanocomposite-modified screen-printed carbon electrode (SPCE) for the sensitive and selective detection of sertraline hydrochloride (SERH), an antidepressant. Mn3O4 nanoparticles were easily synthesized via a hydrothermal method and uniformly combined with AB to form a highly conductive, electrocatalytically active layer on the SPCE. Surface characterization using scanning electron microscopy (SEM) confirmed a homogeneous dispersion of Mn3O4 nanoparticles and a rough, porous, high-surface-area texture that boosts charge transfer. The Mn3O4/AB/SPCE demonstrated superior electrocatalytic activity for SERH oxidation compared with unmodified or modified electrodes, owing to the synergistic effects of Mn3O4 and AB, which enhance surface area, conductivity, and electron-transfer rates. Cyclic voltammetry (CV) analysis showed a clear irreversible oxidation signal for SERH at the Mn3O4/AB-modified electrode surface. Under optimal conditions, differential pulse voltammetry (DPV) showed that the sensor responded linearly to SERH concentrations from 50 nM to 1.0 μM, with a detection limit of 18 nM. The sensor was successfully tested in artificial serum and urine samples, with recovery rates ranging from 99.66% to 100.59%. Also, stability studies under three storage conditions showed that vacuum-sealed storage, particularly at +4 °C, statistically significantly improved the long-term performance of Mn3O4/AB/SPCE. These results suggest that the Mn3O4/AB/SPCE sensor offers a reproducible, stable, and selective platform for monitoring antidepressant drugs in pharmaceutical and biological samples.