The well-known low-complexity JPEG and the newer JPEG-XR systems are based on block-based transform and simple transform-domain coefficient prediction algorithms. Higher complexity image compression algorithms, obtainable from intra-frame coding tools of video coders H.264 or HEVC, are based on multiple block-based spatial-domain prediction modes and transforms. This paper explores an alternative low-complexity image compression approach based on a single spatial-domain prediction mode and transform, which are designed based on a global image model. In our experiments, the proposed single-mode approach uses an average 20.5 % lower bit-rate than a standard low-complexity single-mode image coder that uses only conventional DC spatial prediction and 2-D DCT. It also does not suffer from blocking effects at low bit-rates.