The first enzymatic resolution of quaternary alpha-acetoxy alpha-substituted cyclic ketones


Tanyeli C. , Akhmedov I. M. , İYİGÜN C.

TETRAHEDRON-ASYMMETRY, cilt.17, ss.1125-1128, 2006 (SCI İndekslerine Giren Dergi) identifier identifier

  • Cilt numarası: 17 Konu: 7
  • Basım Tarihi: 2006
  • Doi Numarası: 10.1016/j.tetasy.2006.04.012
  • Dergi Adı: TETRAHEDRON-ASYMMETRY
  • Sayfa Sayıları: ss.1125-1128

Özet

The enantioselective resolution of quaternary alpha-acetoxy alpha-substituted indanone and 1-tetralone derivatives was performed with commercially available enzyme CRL in pH = 8.0 phosphate buffer. Various parameters that would affect the enantoselectivities were tested, and the optimal enzymatic resolution condition was found to afford the enantiomerically enriched quaternary acetoxylated substrates with high ees (varied between 81% and 85%). (c) 2006 Elsevier Ltd. All rights reserved.