The first enzymatic resolution of quaternary alpha-acetoxy alpha-substituted cyclic ketones

Tanyeli C., Akhmedov I. M., İYİGÜN C.

TETRAHEDRON-ASYMMETRY, vol.17, no.7, pp.1125-1128, 2006 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 17 Issue: 7
  • Publication Date: 2006
  • Doi Number: 10.1016/j.tetasy.2006.04.012
  • Journal Name: TETRAHEDRON-ASYMMETRY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1125-1128
  • Middle East Technical University Affiliated: Yes

Abstract

The enantioselective resolution of quaternary alpha-acetoxy alpha-substituted indanone and 1-tetralone derivatives was performed with commercially available enzyme CRL in pH = 8.0 phosphate buffer. Various parameters that would affect the enantoselectivities were tested, and the optimal enzymatic resolution condition was found to afford the enantiomerically enriched quaternary acetoxylated substrates with high ees (varied between 81% and 85%). (c) 2006 Elsevier Ltd. All rights reserved.