Zinc perchlorate catalyzed one-pot amination-annulation of alpha-cyanomethyl-beta-ketoesters in water. Regioselective synthesis of 2-aminopyrrole-4-carboxylates

Demir A. , Emrullahoglu M.

TETRAHEDRON, cilt.62, ss.1452-1458, 2006 (SCI İndekslerine Giren Dergi) identifier identifier

  • Cilt numarası: 62 Konu: 7
  • Basım Tarihi: 2006
  • Doi Numarası: 10.1016/j.tet.2005.11.018
  • Dergi Adı: TETRAHEDRON
  • Sayfa Sayıları: ss.1452-1458


In this paper, we report the efficient and regioselective synthesis of 2-aminopyrrole-4-carboxylates as derivatives of conformationally restricted analogues of gamma-amino butyrates (GABA) via a zinc perchlorate catalyzed amination-annulation of alpha-cyanomethyl-beta-ketoesters under mild reaction conditions in water. (c) 2005 Elsevier Ltd. All rights reserved.