Zinc perchlorate catalyzed one-pot amination-annulation of alpha-cyanomethyl-beta-ketoesters in water. Regioselective synthesis of 2-aminopyrrole-4-carboxylates

Demir, AYHAN; Emrullahoglu, M

doi:10.1016/j.tet.2005.11.018

Zinc perchlorate catalyzed one-pot amination-annulation of alpha-cyanomethyl-beta-ketoesters in water. Regioselective synthesis of 2-aminopyrrole-4-carboxylates

Atıf İçin Kopyala

Demir A. , Emrullahoglu M.

TETRAHEDRON, cilt.62, ss.1452-1458, 2006 (SCI İndekslerine Giren Dergi)

Cilt numarası: 62 Konu: 7
Basım Tarihi: 2006
Doi Numarası: 10.1016/j.tet.2005.11.018
Dergi Adı: TETRAHEDRON
Sayfa Sayıları: ss.1452-1458

Özet

In this paper, we report the efficient and regioselective synthesis of 2-aminopyrrole-4-carboxylates as derivatives of conformationally restricted analogues of gamma-amino butyrates (GABA) via a zinc perchlorate catalyzed amination-annulation of alpha-cyanomethyl-beta-ketoesters under mild reaction conditions in water. (c) 2005 Elsevier Ltd. All rights reserved.