Synthesis of ferrocenyl pyrazoles by the reaction of 3-ferrocenylpropynal with hydrazinium salts

ZORA M., PİNAR A. N., Odabasoglu M., Bueyuekguengoer O., Turgut G.

JOURNAL OF ORGANOMETALLIC CHEMISTRY, cilt.693, sa.1, ss.145-154, 2008 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 693 Sayı: 1
  • Basım Tarihi: 2008
  • Doi Numarası: 10.1016/j.jorganchem.2007.10.035
  • Dergi Adı: JOURNAL OF ORGANOMETALLIC CHEMISTRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.145-154
  • Anahtar Kelimeler: ferrocene, pyrazole, hydrazine, propynal, cyclization, condensation, ESTROGEN-RECEPTOR MODULATORS, ONE-POT SYNTHESIS, ACTIVITY IN-VITRO, REGIOSELECTIVE SYNTHESIS, ANTIMALARIAL ACTIVITY, ORGANOMETALLIC ANALOG, DIACETYLENIC KETONES, EFFICIENT SYNTHESIS, CRYSTAL-STRUCTURES, BUILDING-BLOCK
  • Orta Doğu Teknik Üniversitesi Adresli: Evet

Özet

Synthesis of ferrocenyl-substituted pyrazoles via the reaction between 3-ferrocenylpropynal and hydrazinium salts is described. Depending upon the substitution pattern of hydrazine derivative, the reaction affords 1-alkyl/aryl-5-ferrocenylpyrazoles and/or 1-alkyl/aryl-3-ferrocenylpyrazoles. Structures of 5-ferrocenyl-1-phenyl-1H-pyrazole, 1-benzyl-5-ferrocenyl-1H-pyrazole and 2-(3-ferrocenylpyrazol-1-yl)ethanol were identified by X-ray crystallography. (c) 2007 Elsevier B.V. All rights reserved.